CDC37 and CDK5

Number of citations of the paper that reports this interaction (PubMedID 9150368)
0

Data Source:
HPRD (in vitro)

		CDC37	CDK5
Description		cell division cycle 37, HSP90 cochaperone	cyclin dependent kinase 5
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome Protein Folding Chaperone Complex HSP90-CDC37 Chaperone Complex	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytoplasm Cytosol Microtubule Plasma Membrane Postsynaptic Density Membrane Protein Kinase 5 Complex Lamellipodium Cell Junction Filopodium Axon Dendrite Growth Cone Neuromuscular Junction Cell Projection Neuron Projection Neuronal Cell Body Perikaryon Synapse Presynapse
	Molecular Function	Protein Binding Protein Kinase Regulator Activity Kinase Binding Protein Kinase Binding Heat Shock Protein Binding Unfolded Protein Binding Protein-folding Chaperone Binding Hsp90 Protein Binding Scaffold Protein Binding	Nucleotide Binding P53 Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity ErbB-2 Class Receptor Binding Protein Binding ATP Binding Microtubule Binding Kinase Activity Transferase Activity Signaling Receptor Inhibitor Activity Acetylcholine Receptor Activator Activity Ionotropic Glutamate Receptor Binding ErbB-3 Class Receptor Binding Tau Protein Binding Tau-protein Kinase Activity Hsp90 Protein Binding Protein Serine Kinase Activity
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Folding Protein Targeting Post-transcriptional Regulation Of Gene Expression Protein Stabilization Regulation Of Type II Interferon-mediated Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Type 2 Mitophagy	Microtubule Cytoskeleton Organization Neuron Migration Synaptic Transmission, Dopaminergic Intracellular Protein Transport Apoptotic Process Cell-matrix Adhesion Chemical Synaptic Transmission Nervous System Development Axonogenesis Synapse Assembly Skeletal Muscle Tissue Development Motor Neuron Axon Guidance Associative Learning Visual Learning Schwann Cell Development Synaptic Vesicle Exocytosis Regulation Of Macroautophagy Cell Migration Sensory Perception Of Pain Telencephalon Development Cerebellum Development Cerebellar Cortex Development Cerebellar Cortex Formation Hippocampus Development Layer Formation In Cerebral Cortex Central Nervous System Neuron Development Cerebral Cortex Development Corpus Callosum Development Actin Cytoskeleton Organization Neuron Differentiation Regulation Of Cell Migration Negative Regulation Of Axon Extension Forebrain Development Neuron Projection Development Negative Regulation Of Protein Ubiquitination Negative Regulation Of Synaptic Plasticity Receptor Catabolic Process Synaptic Transmission, Glutamatergic Protein Localization To Synapse Response To Cocaine Regulation Of Apoptotic Process Receptor Clustering Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Cell Cycle Negative Regulation Of Proteolysis Negative Regulation Of DNA-templated Transcription Positive Regulation Of Calcium Ion-dependent Exocytosis Negative Regulation Of Protein Export From Nucleus Behavioral Response To Cocaine Regulation Of Synaptic Plasticity Synaptic Vesicle Endocytosis Synaptic Vesicle Transport Rhythmic Process Axon Extension Oligodendrocyte Differentiation Dendrite Morphogenesis Cell Division Neuron Apoptotic Process Establishment Of Localization In Cell Regulation Of Cell Cycle Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Postsynaptic Membrane Potential Excitatory Postsynaptic Potential Regulation Of Dendritic Spine Morphogenesis Calcium Ion Import Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Presynaptic Cytosolic Calcium Concentration Regulation Of Cell Cycle Phase Transition Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Synaptic Vesicle Recycling Cellular Response To Amyloid-beta
Pathways		Signaling by ERBB2 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Constitutive Signaling by EGFRvIII Regulation of necroptotic cell death Downregulation of ERBB2 signaling RHOBTB2 GTPase cycle Constitutive Signaling by Overexpressed ERBB2 Drug-mediated inhibition of ERBB2 signaling Signaling by ERBB2 KD Mutants Resistance of ERBB2 KD mutants to trastuzumab Resistance of ERBB2 KD mutants to sapitinib Resistance of ERBB2 KD mutants to tesevatinib Resistance of ERBB2 KD mutants to neratinib Resistance of ERBB2 KD mutants to osimertinib Resistance of ERBB2 KD mutants to afatinib Resistance of ERBB2 KD mutants to AEE788 Resistance of ERBB2 KD mutants to lapatinib Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Drug resistance in ERBB2 TMD/JMD mutants	DARPP-32 events CRMPs in Sema3A signaling CRMPs in Sema3A signaling Regulation of TP53 Activity through Phosphorylation Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models NGF-stimulated transcription Activated NTRK2 signals through CDK5 NPAS4 regulates expression of target genes Factors involved in megakaryocyte development and platelet production MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK Phosphorylation and nuclear translocation of the CRY:PER:kinase complex
Drugs			Indirubin-3'-monoxime Olomoucine Hymenialdisine SU9516 Alvocidib Alsterpaullone 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE Trilaciclib
Diseases
GWAS		Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) LDL cholesterol levels in HIV infection ( 33109212) Multiple sclerosis ( 21833088) White blood cell count ( 32888494)	Age at first sexual intercourse ( 34211149) Eyebrow thickness ( 26926045) Hematocrit ( 32888494) Hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494)
Interacting Genes		182 interacting genes: A2M ACTB ACTG1 AKT1 AMOTL2 APOE APP AR BEND7 BLZF1 BTBD10 BTBD3 C19orf44 CAMK2A CAMK2B CAMK2G CARD10 CARD9 CAVIN1 CBY2 CC2D1A CCDC138 CCDC152 CCDC91 CCHCR1 CDC37L1 CDK2 CDK3 CDK4 CDK5 CDK6 CEP55 CEP70 CGGBP1 CHGA CHUK CKS1B CKS2 CRYM CSNK2A1 CSNK2A2 CT45A1 CTAG1A CTAG1B CUTC CYP2C9 DCTN1 DEAF1 DISC1 DRC4 ECSIT EIF2AK1 EIF2S1 ELAVL3 ENOX2 EXOSC1 FAM118A FAM9B FATE1 FBXL12 FBXW4 GABARAP GABARAPL1 GABARAPL2 GAS7 GCDH GCH1 GFAP GMCL1 GOLGA2 GOLGA6L9 GPRASP3 GRAMD2B GRIPAP1 HIVEP1 HOMER3 HSF2BP HSP90AA1 IFIT5 IKBKB IKBKE IKBKG IKZF3 IMMT JRK KATNBL1 KCTD13 KCTD9 KIFC3 KLHL2 KRT75 KRT76 LMNB2 LONP1 LOXL4 LUC7L2 LZTS1 MAD1L1 MAP1LC3A MAP1LC3B MAP1LC3C MAP3K14 MAP3K3 MDFI MID1 MIPOL1 MRPL9 MTOR MZT2B NCOA5 NECAB1 NECAB2 NOS3 NR2C2 NRIP3 NT5C1A OGA OGT PAICS PDE9A PIBF1 PNMA2 POU6F2 PPHLN1 PPP5C PRAM1 PRDX2 PRKAR1B PRMT1 PRMT5 PRPH PRR20A PRR20B PRR20C PRR20D PRR20E PSMC6 PSME1 PTGES3 RABGEF1 RAD23A RAF1 REEP6 RNF32 ROPN1 RPS15A SAFB SEPTIN3 SNX5 SPTBN4 SQSTM1 SRRM4 SSNA1 STAMBPL1 STIP1 STK11 STX1A SYCE2 SYCP3 TBK1 TCF4 THAP1 THAP7 TNFAIP1 TNIP1 TRAF2 TRAF3 TRAF5 TRIM54 UBE2I USHBP1 WAC ZBED1 ZBTB26 ZBTB8A ZNF205 ZNF235 ZNF266 ZNF276 ZNF655 ZNF667 ZNF837	78 interacting genes: AATK ABL1 ACTN1 ALAS1 AMPH APP BAG6 CABLES1 CABLES2 CCND2 CCND3 CCNG1 CDC25A CDC25B CDC25C CDC37 CDK16 CDK5R1 CDK5R2 CDK5RAP1 CDK5RAP2 CDKN1B CHN1 CSNK1D DAB1 DCX DNM1 ERBB3 EZR FSD1 FYN FZR1 GAK GRIN2A GSK3B H1-0 H1-1 H1-5 HTRA2 KIF26B LMTK2 MAP2K1 MAPK10 MAPT MAST1 MBP MEF2A MEOX2 MIR9-1HG NDEL1 NEDD4 NEDD4L NES PAK1 PCNA PIKFYVE PIP5K1C PPARG PPP1R1B PPP1R2 PSEN1 PTPN2 PURA RB1 RNF32 RPL34 SET SPDYA SRC STX1A STXBP1 SYN1 SYNJ1 TLN1 TP53 TRIM59 WASF1 YBX3
Entrez ID		11140	1020
HPRD ID		05456	00449
Ensembl ID		ENSG00000105401	ENSG00000164885
Uniprot IDs		Q16543	A0A090N7W4 A0A0S2Z355 Q00535
PDB IDs		1US7 2K5B 2N5X 2NCA 2W0G 5FWK 5FWL 5FWM 5FWP 5HPE 7Z37 7Z38 7ZR0 7ZR5 7ZR6 8GAE 8GFT 8U1L	1H4L 1UNG 1UNH 1UNL 3O0G 4AU8 7VDP 7VDQ 7VDR 7VDS
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Cytosol Protein Binding Cytoplasm Cellular Response To Nitrogen Starvation Mitophagy Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Serine/threonine Kinase Activity Phosphatidylethanolamine Binding Autophagy Of Mitochondrion Protein Serine Kinase Activity Regulation Of Canonical NF-kappaB Signal Transduction Organelle Organization Macroautophagy Positive Regulation Of Canonical NF-kappaB Signal Transduction Ubiquitin Protein Ligase Binding Positive Regulation Of Signal Transduction CD40 Receptor Complex Protein Kinase Activity Regulation Of Proteolysis Regulation Of Intracellular Signal Transduction Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Localization To Membrane Cyclin-dependent Protein Kinase Holoenzyme Complex IkappaB Kinase Complex Negative Regulation Of Translational Initiation Microtubule Binding Autophagy Regulation Of Protein Localization To Cell Periphery Regulation Of Signal Transduction Intracellular Protein Localization IkappaB Kinase Activity Regulation Of Signaling Regulation Of Cell Communication Serine/threonine Protein Kinase Complex Regulation Of Protein Catabolic Process Kinase Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Synaptic Transmission Cellular Response To Nutrient Levels Cellular Response To Starvation Response To Starvation Toll-like Receptor 4 Signaling Pathway Regulation Of Protein Localization To Plasma Membrane Anoikis Positive Regulation Of TORC1 Signaling Tau Protein Binding Regulation Of Macroautophagy	Protein Kinase Binding Cytosol Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Developmental Process Regulation Of Protein Modification Process Intracellular Signal Transduction Mitotic Cell Cycle Phase Transition Regulation Of Cellular Component Organization Regulation Of Neuron Apoptotic Process Cell Cycle Phase Transition Regulation Of Protein Serine/threonine Kinase Activity Organelle Organization Perinuclear Region Of Cytoplasm Regulation Of Protein Kinase Activity Cytoplasm Cyclin-dependent Protein Kinase Holoenzyme Complex Neuron Apoptotic Process Regulation Of Organelle Organization Regulation Of Kinase Activity Kinase Activity Cell Projection Organization G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Phosphorus Metabolic Process Protein Kinase Activity Regulation Of Phosphorylation Regulation Of Cell Projection Organization Regulation Of Neuron Projection Development Cellular Developmental Process Regulation Of Apoptotic Process Endocytosis Layer Formation In Cerebral Cortex Regulation Of Protein Phosphorylation Organelle Localization Positive Regulation Of Cellular Component Organization Regulation Of Programmed Cell Death Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Protein Catabolic Process Regulation Of Cell Cycle Negative Regulation Of Apoptotic Process Cellular Response To Oxygen-containing Compound Regulation Of Mitotic Cell Cycle Regulation Of Protein-containing Complex Assembly Positive Regulation Of Organelle Organization Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of G2/MI Transition Of Meiotic Cell Cycle Negative Regulation Of Programmed Cell Death
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