ZHX2 and NAGPA

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ZHX2	NAGPA
Description		zinc fingers and homeoboxes 2	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol	Golgi Apparatus Membrane Golgi Cisterna Membrane
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity	N-acetylglucosamine-1-phosphodiester Alpha-N-acetylglucosaminidase Activity Protein Binding Hydrolase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II MRNA Catabolic Process Nervous System Development Central Nervous System Neuron Differentiation Cell Differentiation Somatic Stem Cell Population Maintenance Negative Regulation Of Neuron Differentiation Negative Regulation Of DNA-templated Transcription Retinal Bipolar Neuron Differentiation	Carbohydrate Metabolic Process Protein Glycosylation Protein Targeting To Lysosome Lysosome Organization Secretion Of Lysosomal Enzymes Protein Modification Process
Pathways
Drugs			N-Acetylglucosamine
Diseases
GWAS		Appendicular lean mass ( 33097823) Carotid intima media thickness ( 21909108 30510157) Chin dimples ( 27182965) Immune response to smallpox vaccine (IL-6) ( 22542470) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Reticulocyte count ( 32888494)	Blood protein levels ( 30072576)
Interacting Genes		9 interacting genes: APP ATXN1 DHRS2 LAT NAGPA NFYA YWHAQ ZHX1 ZHX3	7 interacting genes: AP2A1 BDKRB1 CCR8 DEGS1 EPS15 FURIN ZHX2
Entrez ID		22882	51172
HPRD ID		16458	12145
Ensembl ID		ENSG00000178764	ENSG00000103174
Uniprot IDs		Q9Y6X8	Q9UK23
PDB IDs		2DMP 3NAU
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Primary Metabolic Process Adult Locomotory Behavior Negative Regulation Of RNA Biosynthetic Process Visual Behavior Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Visual Learning Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Cellular Localization Protein Heterodimerization Activity Lipoprotein Particle Positive Regulation Of Protein Import Establishment Of Localization In Cell Protein Localization To Lysosome Negative Regulation Of Intralumenal Vesicle Formation Epidermal Growth Factor Catabolic Process Establishment Of Protein Localization To Vacuole Protein Targeting Neurotransmitter Receptor Transport, Postsynaptic Endosome To Lysosome Protein Targeting To Lysosome Protein Targeting To Vacuole Synaptic Vesicle Recycling Via Endosome TCR Signalosome N-acetylglucosamine-1-phosphodiester Alpha-N-acetylglucosaminidase Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Associative Learning Negative Regulation Of Transcription By RNA Polymerase II Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Protein Localization To Vacuole Lipophagy Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Memory Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling POZ Domain Binding	Postsynaptic Endocytic Zone Postsynaptic Neurotransmitter Receptor Internalization AP-2 Adaptor Complex Golgi To Endosome Transport Peptide Binding Receptor Internalization Clathrin-coated Vesicle Clathrin-coated Pit Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Sphingolipid Delta-4 Desaturase Activity Post-Golgi Vesicle-mediated Transport Vesicle-mediated Transport In Synapse Bradykinin Receptor Activity Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Nerve Growth Factor Production Negative Regulation Of Neurotrophin Production Retinol Isomerase Activity Symbiont Entry Into Host Cell Cytosolic Transport Negative Regulation Of Receptor Catabolic Process Regulation Of Biological Quality Negative Regulation Of Hyaluronan Biosynthetic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Viral Translation Viral Life Cycle Plasma Membrane Biological Process Involved In Interaction With Host Cytokine Precursor Processing Nerve Growth Factor Binding Receptor-mediated Endocytosis Ubiquitin-dependent Endocytosis Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Transforming Growth Factor Beta1 Production Clathrin Coat Of Trans-Golgi Network Vesicle Regulation Of Hyaluronan Biosynthetic Process Clathrin Coat Of Coated Pit Heparan Sulfate Binding Signal Peptide Processing Retinal Bipolar Neuron Differentiation Clathrin Adaptor Complex Receptor-mediated Endocytosis Of Virus By Host Cell Negative Regulation Of Transforming Growth Factor Beta Production Golgi Vesicle Transport Positive Regulation Of Receptor Recycling Endocytosis Involved In Viral Entry Into Host Cell
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