ZHX2 and DHRS2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ZHX2	DHRS2
Description		zinc fingers and homeoboxes 2	dehydrogenase/reductase 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol	Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity	Carbonyl Reductase (NADPH) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II MRNA Catabolic Process Nervous System Development Central Nervous System Neuron Differentiation Cell Differentiation Somatic Stem Cell Population Maintenance Negative Regulation Of Neuron Differentiation Negative Regulation Of DNA-templated Transcription Retinal Bipolar Neuron Differentiation	C21-steroid Hormone Metabolic Process Negative Regulation Of Cell Population Proliferation Response To Toxic Substance Electron Transport Chain Cellular Response To Oxidative Stress Myeloid Dendritic Cell Differentiation Negative Regulation Of Apoptotic Process
Pathways
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Carotid intima media thickness ( 21909108 30510157) Chin dimples ( 27182965) Immune response to smallpox vaccine (IL-6) ( 22542470) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Reticulocyte count ( 32888494)
Interacting Genes		9 interacting genes: APP ATXN1 DHRS2 LAT NAGPA NFYA YWHAQ ZHX1 ZHX3	5 interacting genes: APPBP2 EXOSC5 FBXO7 TCEA2 ZHX2
Entrez ID		22882	10202
HPRD ID		16458	07483
Ensembl ID		ENSG00000178764	ENSG00000100867
Uniprot IDs		Q9Y6X8	Q13268
PDB IDs		2DMP 3NAU
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Primary Metabolic Process Adult Locomotory Behavior Negative Regulation Of RNA Biosynthetic Process Visual Behavior Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Visual Learning Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Cellular Localization Protein Heterodimerization Activity Lipoprotein Particle Positive Regulation Of Protein Import Establishment Of Localization In Cell Protein Localization To Lysosome Negative Regulation Of Intralumenal Vesicle Formation Epidermal Growth Factor Catabolic Process Establishment Of Protein Localization To Vacuole Protein Targeting Neurotransmitter Receptor Transport, Postsynaptic Endosome To Lysosome Protein Targeting To Lysosome Protein Targeting To Vacuole Synaptic Vesicle Recycling Via Endosome TCR Signalosome N-acetylglucosamine-1-phosphodiester Alpha-N-acetylglucosaminidase Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Associative Learning Negative Regulation Of Transcription By RNA Polymerase II Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Protein Localization To Vacuole Lipophagy Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Memory Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling POZ Domain Binding	Ubiquitin-like Ligase-substrate Adaptor Activity Macromolecule Catabolic Process Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite MRNA Catabolic Process Nucleoplasm Catabolic Process Lewy Body Core RNA Catabolic Process Macromolecule Metabolic Process Exoribonuclease Complex RNA Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Glutamatergic Neuron Differentiation Retinal Bipolar Neuron Differentiation Nucleobase-containing Compound Catabolic Process Protein Heterodimerization Activity Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cytoplasmic Exosome (RNase Complex) RRNA Catabolic Process Exosome (RNase Complex) Nuclear Exosome (RNase Complex) RNA Exonuclease Activity Sno(s)RNA Metabolic Process Poly(A)-dependent SnoRNA 3'-end Processing U4 SnRNA 3'-end Processing Nuclear MRNA Surveillance DNA Deamination Nucleolar Exosome (RNase Complex) Cul2-RING Ubiquitin Ligase Complex Transcription Elongation Factor Complex Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway SnRNA 3'-end Processing Nucleus Positive Regulation Of Mitophagy Proteasomal Protein Catabolic Process
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