ZHX2 and ZHX3

Number of citations of the paper that reports this interaction (PubMedID 14659886)
0

Data Source:
BioGRID (two hybrid)
HPRD (in vivo, two hybrid, in vitro)

		ZHX2	ZHX3
Description		zinc fingers and homeoboxes 2	zinc fingers and homeoboxes 3
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol	Chromatin Nucleus Nucleoplasm
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II MRNA Catabolic Process Nervous System Development Central Nervous System Neuron Differentiation Cell Differentiation Somatic Stem Cell Population Maintenance Negative Regulation Of Neuron Differentiation Negative Regulation Of DNA-templated Transcription Retinal Bipolar Neuron Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Cell Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of DNA-templated Transcription
Pathways
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Carotid intima media thickness ( 21909108 30510157) Chin dimples ( 27182965) Immune response to smallpox vaccine (IL-6) ( 22542470) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Reticulocyte count ( 32888494)	Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 33020668 29212778) Daytime nap ( 33568662) Fasting blood glucose adjusted for BMI ( 25625282) Fasting glucose ( 34059833) Heel bone mineral density ( 30598549) Height ( 31562340) Hip index ( 34021172) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Low density lipoprotein cholesterol levels ( 29403010) Male-pattern baldness ( 28196072) Multiple sclerosis ( 31604244 24076602) Myocardial infarction ( 33532862) Non-response to bupropion and depression ( 27622933) Refractive error ( 32231278) Resting heart rate ( 27798624) Total cholesterol levels ( 29403010) Type 2 diabetes ( 29632382) Type 2 diabetes (adjusted for BMI) ( 29632382) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		9 interacting genes: APP ATXN1 DHRS2 LAT NAGPA NFYA YWHAQ ZHX1 ZHX3	6 interacting genes: ATXN1 NFYA NLK SH2D2A ZHX1 ZHX2
Entrez ID		22882	23051
HPRD ID		16458	10320
Ensembl ID		ENSG00000178764	ENSG00000174306
Uniprot IDs		Q9Y6X8	Q9H4I2
PDB IDs		2DMP 3NAU	2DA5 2DN0
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Primary Metabolic Process Adult Locomotory Behavior Negative Regulation Of RNA Biosynthetic Process Visual Behavior Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Visual Learning Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Cellular Localization Protein Heterodimerization Activity Lipoprotein Particle Positive Regulation Of Protein Import Establishment Of Localization In Cell Protein Localization To Lysosome Negative Regulation Of Intralumenal Vesicle Formation Epidermal Growth Factor Catabolic Process Establishment Of Protein Localization To Vacuole Protein Targeting Neurotransmitter Receptor Transport, Postsynaptic Endosome To Lysosome Protein Targeting To Lysosome Protein Targeting To Vacuole Synaptic Vesicle Recycling Via Endosome TCR Signalosome N-acetylglucosamine-1-phosphodiester Alpha-N-acetylglucosaminidase Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Associative Learning Negative Regulation Of Transcription By RNA Polymerase II Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Protein Localization To Vacuole Lipophagy Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Memory Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling POZ Domain Binding
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