PTPN3

Description		protein tyrosine phosphatase non-receptor type 3
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane
	Molecular Function	Phosphotyrosine Residue Binding Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Cytoskeletal Protein Binding Hydrolase Activity Sodium Channel Regulator Activity ATPase Binding
	Biological Process	MAPK Cascade Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Membrane Depolarization During Action Potential Regulation Of Sodium Ion Transmembrane Transport
Pathways		EGFR downregulation Negative regulation of MAPK pathway
Drugs
Diseases
GWAS		Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31015462) HIV-associated neurocognitive disorder ( 28447399) HIV-associated neurocognitive disorder (asymptomatic neurocogntive impairment) ( 28447399) HIV-associated neurocognitive disorder (mild neurocognitive disorder or asymptomatic neurocognitive impairment) ( 28447399) Iris color (a* coordinate) ( 30895295) Iris color (b* coordinate) ( 30895295) Red blood cell density in sickle cell anemia ( 28552477) Serum albumin levels ( 29403010) Staphylococcus aureus nasal carriage (persistent) ( 26569114) Triglyceride levels ( 32203549)
Interacting Genes		25 interacting genes: ACE2 ADAM17 AKR1C1 AKT1 CD247 DIP2A GHR HSPB1 LMO1 MAPK12 MLH1 MTMR9 NXT2 PLEKHF2 RNF111 RPS6KA1 TENT5D TFAP4 TRIM41 VCP VWA2 WDR6 YWHAB ZAP70 ZCCHC10
Entrez ID		5774
HPRD ID		06767
Ensembl ID		ENSG00000070159
Uniprot IDs		B7Z3V3 B7Z9V1 B7ZA03 P26045 Q8N4S3
PDB IDs		2B49 4QUM 4QUN 4RH5 4RH9 4RHG 4RI4 4RI5 4S0G 6HKS 6T36 8CQY 8OEP
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Metabolic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Cellular Response To Lipoprotein Particle Stimulus Positive Regulation Of Macromolecule Metabolic Process Protein Serine/threonine/tyrosine Kinase Activity Regulation Of Phosphorus Metabolic Process Negative Regulation Of Metabolic Process Insulin-like Growth Factor Receptor Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Cellular Response To Oxygen-containing Compound Response To Temperature Stimulus Regulation Of Blood Vessel Endothelial Cell Migration Cellular Response To Hormone Stimulus Regulation Of Signal Transduction Regulation Of Protein Modification Process Positive Regulation Of Growth Cellular Response To Vascular Endothelial Growth Factor Stimulus TRNA Methylation Maternal Process Involved In Female Pregnancy Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Negative Regulation Of Autophagy Response To Heat Positive Regulation Of Endothelial Cell Migration Response To Food Response To Growth Hormone Regulation Of TRNA Methylation Response To Lipid Negative Regulation Of Cell Communication Identical Protein Binding Positive Regulation Of Protein Localization To Cell Surface T Cell Receptor Complex Steroid Dehydrogenase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor 3-alpha-hydroxysteroid 3-dehydrogenase [NAD(P)+] Activity Protein Phosphatase Binding Negative Regulation Of Protein Kinase C Signaling Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment Flavin Adenine Dinucleotide Catabolic Process Enzyme Regulator Activity Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Activation Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Activation Regulation Of Endothelial Cell Migration Regulation Of Protein Localization To Cell Surface Regulation Of Cell Population Proliferation Positive Regulation Of Immune Response Positive Regulation Of Biosynthetic Process
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