PTPN3 and NXT2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		PTPN3	NXT2
Description		protein tyrosine phosphatase non-receptor type 3	nuclear transport factor 2 like export factor 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear RNA Export Factor Complex Nuclear Pore Central Transport Channel Perinuclear Region Of Cytoplasm
	Molecular Function	Phosphotyrosine Residue Binding Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Cytoskeletal Protein Binding Hydrolase Activity Sodium Channel Regulator Activity ATPase Binding	Protein Binding
	Biological Process	MAPK Cascade Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Membrane Depolarization During Action Potential Regulation Of Sodium Ion Transmembrane Transport	MRNA Export From Nucleus Nucleocytoplasmic Transport Protein Transport Poly(A)+ MRNA Export From Nucleus MRNA Transport
Pathways		EGFR downregulation Negative regulation of MAPK pathway
Drugs
Diseases
GWAS		Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31015462) HIV-associated neurocognitive disorder ( 28447399) HIV-associated neurocognitive disorder (asymptomatic neurocogntive impairment) ( 28447399) HIV-associated neurocognitive disorder (mild neurocognitive disorder or asymptomatic neurocognitive impairment) ( 28447399) Iris color (a* coordinate) ( 30895295) Iris color (b* coordinate) ( 30895295) Red blood cell density in sickle cell anemia ( 28552477) Serum albumin levels ( 29403010) Staphylococcus aureus nasal carriage (persistent) ( 26569114) Triglyceride levels ( 32203549)
Interacting Genes		25 interacting genes: ACE2 ADAM17 AKR1C1 AKT1 CD247 DIP2A GHR HSPB1 LMO1 MAPK12 MLH1 MTMR9 NXT2 PLEKHF2 RNF111 RPS6KA1 TENT5D TFAP4 TRIM41 VCP VWA2 WDR6 YWHAB ZAP70 ZCCHC10	24 interacting genes: APP CCDC102B CEP63 DDIT4L GOLGA2 GOLGA6L9 IKZF3 LNX1 NXF1 NXF2 NXF2B NXF3 PKM PTPN3 RASSF10 REL SRPK1 SRPK2 SSBP3 STAT3 TCF4 TRIM23 USP54 ZNF655
Entrez ID		5774	55916
HPRD ID		06767	02264
Ensembl ID		ENSG00000070159	ENSG00000101888
Uniprot IDs		B7Z3V3 B7Z9V1 B7ZA03 P26045 Q8N4S3	Q9NPJ8
PDB IDs		2B49 4QUM 4QUN 4RH5 4RH9 4RHG 4RI4 4RI5 4S0G 6HKS 6T36 8CQY 8OEP
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Metabolic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Cellular Response To Lipoprotein Particle Stimulus Positive Regulation Of Macromolecule Metabolic Process Protein Serine/threonine/tyrosine Kinase Activity Regulation Of Phosphorus Metabolic Process Negative Regulation Of Metabolic Process Insulin-like Growth Factor Receptor Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Cellular Response To Oxygen-containing Compound Response To Temperature Stimulus Regulation Of Blood Vessel Endothelial Cell Migration Cellular Response To Hormone Stimulus Regulation Of Signal Transduction Regulation Of Protein Modification Process Positive Regulation Of Growth Cellular Response To Vascular Endothelial Growth Factor Stimulus TRNA Methylation Maternal Process Involved In Female Pregnancy Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Negative Regulation Of Autophagy Response To Heat Positive Regulation Of Endothelial Cell Migration Response To Food Response To Growth Hormone Regulation Of TRNA Methylation Response To Lipid Negative Regulation Of Cell Communication Identical Protein Binding Positive Regulation Of Protein Localization To Cell Surface T Cell Receptor Complex Steroid Dehydrogenase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor 3-alpha-hydroxysteroid 3-dehydrogenase [NAD(P)+] Activity Protein Phosphatase Binding Negative Regulation Of Protein Kinase C Signaling Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment Flavin Adenine Dinucleotide Catabolic Process Enzyme Regulator Activity Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Activation Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Activation Regulation Of Endothelial Cell Migration Regulation Of Protein Localization To Cell Surface Regulation Of Cell Population Proliferation Positive Regulation Of Immune Response Positive Regulation Of Biosynthetic Process	Nuclear RNA Export Factor Complex Poly(A)+ MRNA Export From Nucleus MRNA Export From Nucleus RNA Export From Nucleus Cytoplasm Nuclear Transport Nucleocytoplasmic Transport MRNA Transport Nuclear Export RNA Transport Intracellular Transport Nucleobase-containing Compound Transport Innate Immune Response Defense Response To Symbiont Protein Serine/threonine Kinase Binding Defense Response To Other Organism Response To Other Organism Regulation Of Membrane Protein Ectodomain Proteolysis Cellular Localization Establishment Of Localization In Cell RNA Binding Positive Regulation Of Viral Genome Replication Amyloid-beta Complex Immune Response Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of ATP Metabolic Process Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Spindle Pole Prechordal Plate Formation Midbrain-hindbrain Boundary Initiation
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