PTPN3 and WDR6

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		PTPN3	WDR6
Gene Name		protein tyrosine phosphatase, non-receptor type 3	WD repeat domain 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytoskeleton Cytoplasmic Side Of Plasma Membrane	Cytoplasm Plasma Membrane COP9 Signalosome
	Molecular Function	Phosphotyrosine Binding Protein Tyrosine Phosphatase Activity Protein Binding Cytoskeletal Protein Binding Sodium Channel Regulator Activity ATPase Binding	Protein Binding Poly(A) RNA Binding
	Biological Process	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Membrane Protein Ectodomain Proteolysis Liver Regeneration Regulation Of Membrane Depolarization During Action Potential Regulation Of Sodium Ion Transmembrane Transporter Activity	Cell Cycle Arrest Negative Regulation Of Cell Proliferation Negative Regulation Of Autophagy
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: ADAM17 AKR1C1 CD247 DIP2A GHR LMO1 NXT2 VCP WDR6 YWHAB YWHAG YWHAQ ZAP70 ZCCHC10	4 interactors: BRCA1 CDC42EP4 G2E3 PTPN3
Entrez ID		5774	11180
HPRD ID		06767	06912
Ensembl ID		ENSG00000070159	ENSG00000178252
Uniprot IDs		B7Z3V3 B7Z9V1 B7ZA03 P26045 Q8N4S3	B3KRR8 E9PDU5 Q9H9M3 Q9NNW5
PDB IDs		2B49
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Cellular Response To Hormone Stimulus Regulation Of Mitochondrion Organization Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Positive Regulation Of Signal Transduction Apoptotic Signaling Pathway Regulation Of Apoptotic Process JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Response To Peptide Hormone Growth Hormone Receptor Signaling Pathway Regulation Of Cell Death Cellular Response To Organonitrogen Compound Cellular Response To Growth Hormone Stimulus Response To Hormone Response To Peptide Apoptotic Process Programmed Cell Death Intrinsic Apoptotic Signaling Pathway Cell Death Positive Regulation Of Apoptotic Signaling Pathway Death Response To Growth Hormone Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Intracellular Signal Transduction Cellular Response To Organic Substance Positive Regulation Of Cell Death Positive Regulation Of Intracellular Transport Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway JAK-STAT Cascade Regulation Of Protein Kinase Activity Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination Protein Transport Signaling T Cell Differentiation In Thymus Regulation Of Kinase Activity Cell Communication Establishment Of Protein Localization Response To Organonitrogen Compound Immune Response-regulating Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Multicellular Organismal Metabolic Process Beta Selection Positive Regulation Of Protein Modification Process	Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Protein Polyubiquitination Positive Regulation Of Histone H3-K9 Acetylation Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Liver Regeneration Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Membrane Depolarization During Action Potential Cellular Response To Indole-3-methanol Negative Regulation Of Centriole Replication Negative Regulation Of Membrane Protein Ectodomain Proteolysis Dosage Compensation By Inactivation Of X Chromosome Protein K6-linked Ubiquitination Negative Regulation Of Histone H3-K9 Methylation Positive Regulation Of Histone H3-K9 Methylation Dosage Compensation Regulation Of Histone H3-K9 Acetylation Positive Regulation Of Organelle Organization Regulation Of Centriole Replication Positive Regulation Of Histone H3-K4 Methylation Regulation Of Histone H4 Acetylation Negative Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Pseudopodium Assembly DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Negative Regulation Of Cell Cycle DNA Damage Response, Signal Transduction Resulting In Transcription Negative Regulation Of Histone Methylation Regulation Of Cytoskeleton Organization Negative Regulation Of Centrosome Duplication Regulation Of DNA Methylation Negative Regulation Of Histone Acetylation Positive Regulation Of Histone Acetylation Negative Regulation Of Peptidyl-lysine Acetylation Regulation Of Histone H3-K4 Methylation Protein Ubiquitination Negative Regulation Of Protein Acetylation Positive Regulation Of Peptidyl-lysine Acetylation Postreplication Repair Positive Regulation Of Protein Acetylation Protein Modification By Small Protein Conjugation Regulation Of Transcription From RNA Polymerase III Promoter Negative Regulation Of Fatty Acid Metabolic Process Regulation Of Gene Expression By Genetic Imprinting Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Sodium Ion Transmembrane Transporter Activity Genetic Imprinting Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Vascular Endothelial Growth Factor Production G2 DNA Damage Checkpoint
Tagcloud ?		adaptor advance border cascades dephosphorylation doi dptpmeg drosophila egfr endocytosis eps15 ferm homolog impairs lysosomal morphogenesis onc oncogene online pdz publication raft scaffolding september suppress trafficking tumorigenicity wing xenograft
Tagcloud (Difference) ?		adaptor advance border cascades dephosphorylation doi dptpmeg drosophila egfr endocytosis eps15 ferm homolog impairs lysosomal morphogenesis onc oncogene online pdz publication raft scaffolding september suppress trafficking tumorigenicity wing xenograft
Tagcloud (Intersection) ?