GH1

Description		growth hormone 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endomembrane System Extracellular Matrix Endosome Lumen Vesicle Growth Hormone Receptor Complex
	Molecular Function	Cytokine Activity Growth Hormone Receptor Binding Prolactin Receptor Binding Hormone Activity Protein Binding Growth Factor Activity Metal Ion Binding Growth Hormone Activity
	Biological Process	Positive Regulation Of Receptor Internalization Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of D-glucose Transmembrane Transport Cytokine-mediated Signaling Pathway Response To Nutrient Levels Response To Estradiol Positive Regulation Of Multicellular Organism Growth Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Animal Organ Development Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Growth Hormone Receptor Signaling Pathway Bone Maturation Cell Surface Receptor Signaling Pathway Via STAT
Pathways		Prolactin receptor signaling Prolactin receptor signaling Synthesis, secretion, and deacylation of Ghrelin Growth hormone receptor signaling Growth hormone receptor signaling
Drugs
Diseases		Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		Appendicular lean mass ( 33097823) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)
Interacting Genes		7 interacting genes: GHR PRLR PSMD9 S100A6 S100P SHC1 TREM2
Entrez ID		2688
HPRD ID		00751
Ensembl ID		ENSG00000259384
Uniprot IDs		B1A4G6 B1A4G7 P01241
PDB IDs		1A22 1AXI 1BP3 1HGU 1HUW 1HWG 1HWH 1KF9 3HHR 6QIO
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Lipid Binding Peptide Hormone Binding Extracellular Region Regulation Of Cell Population Proliferation Protein Tyrosine Kinase Binding Insulin-like Growth Factor Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Cytokine Binding Cell Surface Receptor Signaling Pathway Via JAK-STAT Cytokine Receptor Activity Response To Bacterium Calcium-dependent Protein Binding Positive Regulation Of CD40 Signaling Pathway Positive Regulation Of C-C Chemokine Receptor CCR7 Signaling Pathway Positive Regulation Of Complement Activation, Classical Pathway Detection Of Lipoteichoic Acid Excitatory Synapse Pruning Positive Regulation Of Synapse Pruning Regulation Of Toll-like Receptor 6 Signaling Pathway Growth Hormone Receptor Activity Positive Regulation Of MAPK Cascade Prolactin Receptor Activity Shc-EGFR Complex Positive Regulation Of Engulfment Of Apoptotic Cell Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Detection Of Peptidoglycan Regulation Of Engulfment Of Apoptotic Cell Growth Hormone Receptor Complex Response To Cycloheximide Regulation Of MAPK Cascade Protein Homodimerization Activity Plasma Membrane Hormone-mediated Signaling Pathway Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Prolactin Signaling Pathway Activation Of Janus Kinase Activity Proteasome Regulatory Particle Assembly Positive Regulation Of Protein Secretion Positive Regulation Of Cell Proliferation In Bone Marrow Phospholipid Binding Epidermal Growth Factor Binding Regulation Of Cell Proliferation In Bone Marrow Positive Regulation Of ERK1 And ERK2 Cascade Neurotrophin TRKA Receptor Binding Positive Regulation Of Macrophage Fusion Sulfatide Binding Negative Regulation Of Astrocyte Activation CXCL12-activated CXCR4 Signaling Pathway
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