GH1 and PRLR

Number of citations of the paper that reports this interaction (PMID 9556914)
0

Data Source:
HPRD (in vitro)

		GH1	PRLR
Gene Name		growth hormone 1	prolactin receptor
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Plasma Membrane Cell Surface Integral Component Of Membrane Endosome Lumen
	Molecular Function	Growth Hormone Receptor Binding Prolactin Receptor Binding Hormone Activity Protein Binding Growth Factor Activity Metal Ion Binding	Prolactin Receptor Activity Protein Binding Peptide Hormone Binding Protein Homodimerization Activity Ornithine Decarboxylase Activator Activity Metal Ion Binding
	Biological Process	Positive Regulation Of Receptor Internalization JAK-STAT Cascade Positive Regulation Of Activation Of JAK2 Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Glucose Transport Response To Estradiol Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Positive Regulation Of MAP Kinase Activity Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of JAK-STAT Cascade Positive Regulation Of Peptidyl-tyrosine Phosphorylation Growth Hormone Receptor Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Bone Maturation	Steroid Biosynthetic Process Cell Surface Receptor Signaling Pathway Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Embryo Implantation Lactation Regulation Of Cell Adhesion Regulation Of Epithelial Cell Differentiation Prolactin Signaling Pathway T Cell Activation Activation Of JAK2 Kinase Activity Negative Regulation Of Apoptotic Process JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Mammary Gland Epithelial Cell Differentiation Prostate Gland Growth Mammary Gland Alveolus Development
Pathways		Peptide hormone metabolism Nuclear signaling by ERBB4 Synthesis, secretion, and deacylation of Ghrelin Cytokine Signaling in Immune system Signaling by ERBB4 Prolactin receptor signaling Growth hormone receptor signaling	Nuclear signaling by ERBB4 Cytokine Signaling in Immune system Signaling by ERBB4 Prolactin receptor signaling Growth hormone receptor signaling
Drugs			Somatropin recombinant Fluoxymesterone
Diseases
GWAS
Protein-Protein Interactions		4 interactors: BTRC GHR PRLR SHC1	18 interactors: CISH CREBBP CSH1 FBXW11 GH1 JAK2 NEK3 PPIA PRL PTPN11 SOCS2 SOCS3 TEC VAV1 VAV2 YWHAG YWHAZ ZAP70
Entrez ID		2688	5618
HPRD ID		00751	01457
Ensembl ID		ENSG00000259384	ENSG00000113494
Uniprot IDs		B1A4G6 B1A4G7 B1A4G9 B1A4H0 P01241	P16471
PDB IDs		1A22 1AXI 1BP3 1HGU 1HUW 1HWG 1HWH 1KF9 3HHR	1BP3 2LFG 3D48 3MZG 3N06 3N0P 3NCB 3NCC 3NCE 3NCF
Enriched GO Terms of Interacting Partners?		Activation Of JAK2 Kinase Activity Positive Regulation Of Transferase Activity Activation Of Janus Kinase Activity Positive Regulation Of Protein Modification Process JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Activation Of Protein Kinase Activity Growth Hormone Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Cellular Response To Growth Hormone Stimulus Positive Regulation Of Protein Metabolic Process Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Response To Growth Hormone Positive Regulation Of Catalytic Activity JAK-STAT Cascade Response To Peptide Hormone Positive Regulation Of Protein Kinase Activity Cellular Response To Organonitrogen Compound Regulation Of Intracellular Signal Transduction Response To Peptide Positive Regulation Of Kinase Activity Positive Regulation Of JAK-STAT Cascade Cellular Response To Organic Substance Regulation Of Cellular Protein Metabolic Process Cellular Response To Hormone Stimulus Regulation Of Protein Metabolic Process Regulation Of JAK-STAT Cascade Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Mammary Gland Epithelium Development Regulation Of Catalytic Activity Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Response To Organonitrogen Compound Positive Regulation Of Phosphorylation Regulation Of Signal Transduction Activation Of MAPK Activity Enzyme Linked Receptor Protein Signaling Pathway Phosphate-containing Compound Metabolic Process Response To Hormone Peptidyl-amino Acid Modification Mammary Gland Development Regulation Of Signaling Cell Surface Receptor Signaling Pathway Cellular Protein Modification Process Regulation Of Protein Phosphorylation	JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Response To Growth Hormone Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway JAK-STAT Cascade Enzyme Linked Receptor Protein Signaling Pathway Response To Peptide Hormone Response To Peptide Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Intracellular Signal Transduction Cellular Response To Hormone Stimulus Cellular Response To Organonitrogen Compound Regulation Of JAK-STAT Cascade Response To Organonitrogen Compound Regulation Of Signal Transduction Response To Hormone Cellular Response To Organic Substance Regulation Of Signaling Cell Surface Receptor Signaling Pathway Signal Transduction Regulation Of Intracellular Signal Transduction Signaling Cell Communication Response To Organic Substance Regulation Of Kinase Activity Innate Immune Response Immune System Process Cellular Response To Stimulus Immune Response Regulation Of Body Fluid Levels Wound Healing Defense Response Response To Stimulus Negative Regulation Of JAK-STAT Cascade Regulation Of Cellular Response To Insulin Stimulus Response To Wounding Blood Coagulation Hemostasis Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction Regulation Of Immune Response Regulation Of Phosphorylation Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cellular Protein Modification Process
Tagcloud ?		anchor anchorage artificial assign bac backcross bacs bands bovine bta19 centromere chrnb1 chromosomes colour construct cryb1 fish hybrid interspecies library linkage locations loci map meiotic nf1 p4hb tp53 unresolved	abolished cdna cdnas changed cis1 cis2 cis3 cis4 comparable expressions gland glands hint inducible jab little luciferase mammary myc postpartum prolactin reporter responsive sh2 slightly stat5 tagged transfected transiently
Tagcloud (Difference) ?		anchor anchorage artificial assign bac backcross bacs bands bovine bta19 centromere chrnb1 chromosomes colour construct cryb1 fish hybrid interspecies library linkage locations loci map meiotic nf1 p4hb tp53 unresolved	abolished cdna cdnas changed cis1 cis2 cis3 cis4 comparable expressions gland glands hint inducible jab little luciferase mammary myc postpartum prolactin reporter responsive sh2 slightly stat5 tagged transfected transiently
Tagcloud (Intersection) ?