GH1 and S100A6

Number of citations of the paper that reports this interaction (PubMedID 37759746)
234

Data Source:
BioGRID (pull down)

		GH1	S100A6
Description		growth hormone 1	S100 calcium binding protein A6
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endomembrane System Extracellular Matrix Endosome Lumen Vesicle Growth Hormone Receptor Complex	Ruffle Extracellular Region Nucleus Nuclear Envelope Cytoplasm Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Extracellular Matrix Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Cytokine Activity Growth Hormone Receptor Binding Prolactin Receptor Binding Hormone Activity Protein Binding Growth Factor Activity Metal Ion Binding Growth Hormone Activity	Calcium Ion Binding Protein Binding Tropomyosin Binding Zinc Ion Binding Monoatomic Ion Transmembrane Transporter Activity Identical Protein Binding Protein Homodimerization Activity S100 Protein Binding Metal Ion Binding Calcium-dependent Protein Binding
	Biological Process	Positive Regulation Of Receptor Internalization Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of D-glucose Transmembrane Transport Cytokine-mediated Signaling Pathway Response To Nutrient Levels Response To Estradiol Positive Regulation Of Multicellular Organism Growth Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Animal Organ Development Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Growth Hormone Receptor Signaling Pathway Bone Maturation Cell Surface Receptor Signaling Pathway Via STAT	Signal Transduction Axonogenesis Monoatomic Ion Transmembrane Transport Positive Regulation Of Fibroblast Proliferation
Pathways		Prolactin receptor signaling Prolactin receptor signaling Synthesis, secretion, and deacylation of Ghrelin Growth hormone receptor signaling Growth hormone receptor signaling
Drugs			Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases		Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		Appendicular lean mass ( 33097823) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)	HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535)
Interacting Genes		7 interacting genes: GHR PRLR PSMD9 S100A6 S100P SHC1 TREM2	50 interacting genes: ANXA11 ANXA2 CACYBP CEP20 CEP43 CLCF1 CNTF CSF2 CSF3 CTF1 EBI3 EPO FAM25A FAM25C FAM25G FKBP4 FLT3LG GAPDH GH1 GH2 IFNB1 IFNW1 IL10 IL11 IL12A IL13 IL15 IL19 IL2 IL20 IL21 IL22 IL24 IL26 IL27 IL3 IL31 IL5 IL9 KITLG LEP MDM2 OFD1 PEX5 PPID PRL S100B SUGT1 THPO TP53
Entrez ID		2688	6277
HPRD ID		00751	00237
Ensembl ID		ENSG00000259384	ENSG00000197956
Uniprot IDs		B1A4G6 B1A4G7 P01241	P06703
PDB IDs		1A22 1AXI 1BP3 1HGU 1HUW 1HWG 1HWH 1KF9 3HHR 6QIO	1K8U 1K96 1K9K 1K9P 2M1K 4YBH
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Lipid Binding Peptide Hormone Binding Extracellular Region Regulation Of Cell Population Proliferation Protein Tyrosine Kinase Binding Insulin-like Growth Factor Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Cytokine Binding Cell Surface Receptor Signaling Pathway Via JAK-STAT Cytokine Receptor Activity Response To Bacterium Calcium-dependent Protein Binding Positive Regulation Of CD40 Signaling Pathway Positive Regulation Of C-C Chemokine Receptor CCR7 Signaling Pathway Positive Regulation Of Complement Activation, Classical Pathway Detection Of Lipoteichoic Acid Excitatory Synapse Pruning Positive Regulation Of Synapse Pruning Regulation Of Toll-like Receptor 6 Signaling Pathway Growth Hormone Receptor Activity Positive Regulation Of MAPK Cascade Prolactin Receptor Activity Shc-EGFR Complex Positive Regulation Of Engulfment Of Apoptotic Cell Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Detection Of Peptidoglycan Regulation Of Engulfment Of Apoptotic Cell Growth Hormone Receptor Complex Response To Cycloheximide Regulation Of MAPK Cascade Protein Homodimerization Activity Plasma Membrane Hormone-mediated Signaling Pathway Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Prolactin Signaling Pathway Activation Of Janus Kinase Activity Proteasome Regulatory Particle Assembly Positive Regulation Of Protein Secretion Positive Regulation Of Cell Proliferation In Bone Marrow Phospholipid Binding Epidermal Growth Factor Binding Regulation Of Cell Proliferation In Bone Marrow Positive Regulation Of ERK1 And ERK2 Cascade Neurotrophin TRKA Receptor Binding Positive Regulation Of Macrophage Fusion Sulfatide Binding Negative Regulation Of Astrocyte Activation CXCL12-activated CXCR4 Signaling Pathway	Cytokine Activity Extracellular Space Cytokine-mediated Signaling Pathway Extracellular Region Growth Factor Activity Positive Regulation Of Cell Population Proliferation Regulation Of Cell Population Proliferation Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Leukocyte Proliferation Positive Regulation Of Leukocyte Proliferation Leukocyte Differentiation Cell Activation Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Immune System Process Leukocyte Activation Cytokine Receptor Binding Regulation Of Multicellular Organismal Process Lymphocyte Activation Signal Transduction Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Lymphocyte Activation Regulation Of Lymphocyte Activation Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Regulation Of Receptor Signaling Pathway Via JAK-STAT Immune Response Positive Regulation Of Receptor Signaling Pathway Via STAT Positive Regulation Of Cell Activation Lymphocyte Differentiation Mononuclear Cell Differentiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cell Activation Positive Regulation Of Developmental Process Positive Regulation Of Gene Expression Regulation Of Cell Differentiation Cell Surface Receptor Signaling Pathway Via JAK-STAT Lymphocyte Proliferation Positive Regulation Of Cytokine Production Regulation Of Developmental Process Mononuclear Cell Proliferation Positive Regulation Of Macromolecule Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Leukocyte Proliferation Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of T Cell Activation T Cell Activation
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