TADA2A and CCDC134

Number of citations: 0 (PubMedID 22644376)
Data Source: BioGRID (pull down, affinity chromatography technology)

		TADA2A	CCDC134
Name		transcriptional adaptor 2A	coiled-coil domain containing 134
Structure			No pdb structure
GO Annotations	Cellular Component	SAGA Complex Nucleus Nucleoplasm Chromosome SAGA-type Complex Mitotic Spindle ATAC Complex	Extracellular Region Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Cytosol Membrane
	Molecular Function	DNA Binding Chromatin Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding Protein-macromolecule Adaptor Activity
	Biological Process	Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Regulation Of Embryonic Development Regulation Of Cell Division Regulation Of Cell Cycle	Angiogenesis Placenta Development Ventricular System Development Positive Regulation Of Wnt Signaling Pathway Regulation Of Ossification Positive Regulation Of MyD88-dependent Toll-like Receptor Signaling Pathway Embryonic Hemopoiesis Regulation Of Protein Glycosylation Embryonic Liver Development
Pathways		HATs acetylate histones Formation of WDR5-containing histone-modifying complexes	None
GWAS		Hip bone mineral density and total body fat mass (bivariate analysis) ( 32963334 ) Monocyte percentage of white cells ( 32888494 ) Ovarian cancer ( 23535730 ) Plateletcrit ( 32888494 ) White blood cell count ( 32888494 )	Alanine aminotransferase levels ( 33547301 ) Alzheimer's disease biomarkers ( 21123754 ) Intelligence (MTAG) ( 29326435 ) Meat-related diet ( 32066663 ) Plateletcrit ( 32888494 ) Processed meat consumption ( 32066663 ) Refractive error ( 32231278 )
Novel Interactors		None recorded	1 novel interactors: CENPM
Interacting Genes		49 interacting genes: AIRIM ARNT2 CCDC116 CCDC134 CCHCR1 CDCA7L EIF4E2 EXOC8 FAM107A FANCG FARS2 FBF1 GPSM3 HGS HNRNPLL KAT2A KLC4 KLHL38 KPNA2 LMO1 MAGOH MAGOHB MCPH1 MFAP1 MKRN3 MTX2 MYC NFE2L2 NOL4L-DT NR3C1 PPP1R16B PRKAB2 PRPF31 QARS1 RNF6 RTL8B SF3A3 TADA3 TCF3 TEKT4 THOC1 TTC23 TTC9C VPS25 ZCCHC12 ZFYVE26 ZNF417 ZNF564 ZNF688	4 interacting genes: PGRMC1 PTPRN TADA2A UBQLN4
Entrez ID		6871	79879
HPRD ID		03784	07988
Ensembl ID		ENSG00000276234	ENSG00000100147
Uniprot IDs		A0A024R0Y4 A0A087WWR4 A0A0S2Z4G1 B3KU13 O75478	B0QY51 B4DRL0 Q9H6E4
PDB IDs		1X41	Not available
GO Terms Enriched among Interactors		Protein Binding U2-type Precatalytic Spliceosome Nuclear Speck Exon-exon Junction Subcomplex Mago-y14 Nucleus U2-type Spliceosomal Complex Spliceosomal Complex MRNA Splicing, Via Spliceosome MRNA Processing Negative Regulation Of Stress-activated MAPK Cascade Membrane Fission RNA Splicing, Via Transesterification Reactions Negative Regulation Of Stress-activated Protein Kinase Signaling Cascade Cytoplasm Centrosome Nuclear Export RNA Splicing ATAC Complex Nuclear Transport Nucleocytoplasmic Transport Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay	Dense Core Granule Maturation Secretory Granule Maturation Positive Regulation Of Type B Pancreatic Cell Proliferation Chromosome SAGA-type Complex Positive Regulation Of Lipoprotein Transport Negative Regulation Of Autophagosome Maturation Nuclear Proteasome Complex Cytosolic Proteasome Complex