TADA2A and MCPH1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		TADA2A	MCPH1
Gene Name		transcriptional adaptor 2A	microcephalin 1
Image
Gene Ontology Annotations	Cellular Component	PCAF Complex Nucleus Chromosome	Nucleoplasm Cytoplasm Microtubule Organizing Center
	Molecular Function	DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Cofactor Activity Histone Acetyltransferase Activity Zinc Ion Binding	Protein Binding Identical Protein Binding
	Biological Process	Chromatin Organization Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Histone H3 Acetylation	Mitotic Cell Cycle Cerebral Cortex Development
Pathways		Chromatin modifying enzymes Chromatin organization HATs acetylate histones	Mitotic Prophase Condensation of Prophase Chromosomes Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS		Ovarian cancer ( 23535730)	Cytomegalovirus antibody response ( 21993531) Epirubicin-induced leukopenia ( 21799462)
Protein-Protein Interactions		34 interactors: ARNT2 C1orf109 CCHCR1 CDCA7L EIF4E2 EXOC8 FAM107A FAM127C FARS2 FBF1 GPSM3 HGS KAT2A KLC4 KLHL38 KPNA2 LOC149950 MAGOH MCPH1 MFAP1 MTX2 MYC NR3C1 PPP1R16B PRKAB2 PRPF31 SF3A3 TADA3 TCF3 TEKT4 TTC23 TTC9C ZFYVE26 ZNF564	9 interactors: ABCC2 CHEK1 H2AFX KDM1A MCM2 PHF11 SMARCB1 SMARCC2 TADA2A
Entrez ID		6871	79648
HPRD ID		03784	06174
Ensembl ID		ENSG00000108264	ENSG00000147316
Uniprot IDs		O75478	Q8NEM0
PDB IDs		1X41	2WT8 3KTF 3PA6 3SHT 3SHV 3SZM 3T1N 3U3Z
Enriched GO Terms of Interacting Partners?		Histone H3 Acetylation Gene Expression RNA Metabolic Process Posttranscriptional Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Histone Acetylation Heterocycle Metabolic Process Internal Peptidyl-lysine Acetylation Cellular Aromatic Compound Metabolic Process Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Regulation Of Protein Stability Cellular Nitrogen Compound Metabolic Process Chromatin Modification Transcription, DNA-templated Cytoplasmic Transport RNA Biosynthetic Process Chromatin Organization Regulation Of Gluconeogenesis Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Glucocorticoid Mediated Signaling Pathway Exocyst Assembly Cellular Macromolecule Biosynthetic Process Establishment Of Localization In Cell Positive Regulation Of Gene Expression Nitrogen Compound Metabolic Process Histone H4 Acetylation Macromolecule Biosynthetic Process Regulation Of Chromosome Organization Organelle Organization Positive Regulation Of Cell Proliferation MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Negative Regulation Of Peptidyl-serine Dephosphorylation Fibroblast Apoptotic Process Protein Localization To Organelle Transcription From RNA Polymerase II Promoter Peptidyl-lysine Modification Intracellular Steroid Hormone Receptor Signaling Pathway Nucleocytoplasmic Transport Nuclear Transport Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Glucocorticoid Mediated Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Regulation Of Chromosome Condensation Regulation Of Metabolic Process Cellular Protein Localization Cellular Localization	Chromatin Organization Chromosome Organization Nucleosome Organization Chromatin Assembly Or Disassembly Chromatin Modification Regulation Of Histone Modification Regulation Of Response To DNA Damage Stimulus Nucleosome Disassembly Nucleobase-containing Compound Metabolic Process Cell Cycle Process Organelle Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Chromatin Remodeling Regulation Of Chromosome Organization Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cell Cycle Nitrogen Compound Metabolic Process Mitotic Cell Cycle Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Cellular Response To DNA Damage Stimulus Regulation Of DNA Repair ATP-dependent Chromatin Remodeling Histone Modification Biosynthetic Process Regulation Of Primitive Erythrocyte Differentiation DNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Response To Stress Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Prostaglandin Transport Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Histone H3-T11 Phosphorylation Transcription, DNA-templated Nucleosome Assembly RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Chromatin Assembly DNA Repair Positive Regulation Of Cellular Metabolic Process DNA Damage Checkpoint Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Protein-DNA Complex Assembly Positive Regulation Of Gene Expression
Tagcloud ?			8p23 aberrantly advance alleviated aneuploidy bona break breaks brit1 centrosome chromatid comet convincing doi dsb fide heterozygosity joining karyotyping lymphomas meanwhile mefs metaphase multiplication onc online publication reconstituted
Tagcloud (Difference) ?			8p23 aberrantly advance alleviated aneuploidy bona break breaks brit1 centrosome chromatid comet convincing doi dsb fide heterozygosity joining karyotyping lymphomas meanwhile mefs metaphase multiplication onc online publication reconstituted
Tagcloud (Intersection) ?