TADA2A and THOC1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TADA2A	THOC1
Description		transcriptional adaptor 2A	THO complex subunit 1
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GO Annotations	Cellular Component	SAGA Complex Nucleus Nucleoplasm Chromosome SAGA-type Complex Mitotic Spindle ATAC Complex	Transcription Export Complex THO Complex THO Complex Part Of Transcription Export Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Nuclear Speck
	Molecular Function	DNA Binding Chromatin Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Zinc Ion Binding Metal Ion Binding	DNA Binding RNA Binding Protein Binding Identical Protein Binding
	Biological Process	Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Regulation Of Embryonic Development Regulation Of Cell Division Regulation Of Cell Cycle	MRNA Processing MRNA Export From Nucleus Apoptotic Process Signal Transduction RNA Splicing MRNA Transport
Pathways		HATs acetylate histones Formation of WDR5-containing histone-modifying complexes	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS		Hip bone mineral density and total body fat mass (bivariate analysis) ( 32963334) Monocyte percentage of white cells ( 32888494) Ovarian cancer ( 23535730) Plateletcrit ( 32888494) White blood cell count ( 32888494)	Bipolar disorder ( 20351715) Bipolar disorder or major depressive disorder ( 20351715) Height ( 31562340) Menarche (age at onset) ( 29773799) Triglyceride levels ( 32203549)
Interacting Genes		49 interacting genes: AIRIM ARNT2 CCDC116 CCDC134 CCHCR1 CDCA7L EIF4E2 EXOC8 FAM107A FANCG FARS2 FBF1 GPSM3 HGS HNRNPLL KAT2A KLC4 KLHL38 KPNA2 LMO1 MAGOH MAGOHB MCPH1 MFAP1 MKRN3 MTX2 MYC NFE2L2 NOL4L-DT NR3C1 PPP1R16B PRKAB2 PRPF31 QARS1 RNF6 RTL8B SF3A3 TADA3 TCF3 TEKT4 THOC1 TTC23 TTC9C VPS25 ZCCHC12 ZFYVE26 ZNF417 ZNF564 ZNF688	32 interacting genes: AGR2 AKAP9 CTAG1A CTAG1B DHX8 ESS2 EXOC5 EXOSC7 FRA10AC1 GPRASP3 IK MAGEB4 MOAP1 MTNR1B NEDD4 PAX6 PPP1R12C PRC1 PRPF6 RABGEF1 RB1 REL SAP30BP SF3B2 SNW1 TADA2A TFIP11 TRIM27 TRIM54 USHBP1 WDR77 ZMYND12
Entrez ID		6871	9984
HPRD ID		03784	09498
Ensembl ID		ENSG00000276234	ENSG00000079134
Uniprot IDs		A0A024R0Y4 A0A087WWR4 A0A0S2Z4G1 B3KU13 O75478	Q96FV9
PDB IDs		1X41	1WXP 7APK 7ZNK 7ZNL
Enriched GO Terms of Interacting Partners?		Protein Binding U2-type Precatalytic Spliceosome Nuclear Speck Exon-exon Junction Subcomplex Mago-y14 Nucleus U2-type Spliceosomal Complex Spliceosomal Complex MRNA Splicing, Via Spliceosome MRNA Processing Negative Regulation Of Stress-activated MAPK Cascade Membrane Fission RNA Splicing, Via Transesterification Reactions Negative Regulation Of Stress-activated Protein Kinase Signaling Cascade Cytoplasm Centrosome Nuclear Export RNA Splicing ATAC Complex Nuclear Transport Nucleocytoplasmic Transport Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay	MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Catalytic Step 2 Spliceosome Spliceosomal Complex RNA Metabolic Process RNA Splicing MRNA Processing MRNA Metabolic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Processing Cyclin/CDK Positive Transcription Elongation Factor Complex U2-type Precatalytic Spliceosome
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