GCG and MEP1A

Number of citations of the paper that reports this interaction (PMID 11278902)
30

Data Source:
HPRD (in vitro)

		GCG	MEP1A
Gene Name		glucagon	meprin A, alpha (PABA peptide hydrolase)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Secretory Granule Lumen	Extracellular Space Integral Component Of Plasma Membrane Meprin A Complex Extracellular Vesicular Exosome
	Molecular Function	Receptor Binding Hormone Activity Protein Binding Glucagon Receptor Binding Identical Protein Binding	Metalloendopeptidase Activity Protein Binding Zinc Ion Binding
	Biological Process	Energy Reserve Metabolic Process Signal Transduction G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Feeding Behavior Cell Proliferation Protein Kinase A Signaling Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of Protein Binding Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Gluconeogenesis By Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Starvation Negative Regulation Of Apoptotic Process Cellular Protein Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Protein Kinase Activity Regulation Of Insulin Secretion Positive Regulation Of Histone H3-K4 Methylation Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Glucagon Stimulus Positive Regulation Of Calcium Ion Import Negative Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Proteolysis Digestion
Pathways		G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Synthesis, secretion, and deacylation of Ghrelin Integration of energy metabolism G alpha (s) signalling events Regulation of insulin secretion Glucagon-type ligand receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding G alpha (q) signalling events Peptide hormone metabolism GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Class B/2 (Secretin family receptors) Glucagon signaling in metabolic regulation Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Incretin synthesis, secretion, and inactivation
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: CPE CTSL GCGR GLP1R GLP2R MEP1A MEP1B	19 interactors: AGT BDKRB1 CCK FN1 GCG GNRH1 GRP KNG1 LAMA1 LAMA5 MEP1B NPY NTS PLG POMC PTH SCT TAC1 VIP
Entrez ID		2641	4224
HPRD ID		00676	02666
Ensembl ID		ENSG00000115263	ENSG00000112818
Uniprot IDs		P01275	B7ZL91 Q16819
PDB IDs		1BH0 1D0R 1NAU 2G49 2L63 2L64 2M5P 2M5Q 3IOL
Enriched GO Terms of Interacting Partners?		Cellular Response To Glucagon Stimulus Response To Glucagon Cellular Response To Hormone Stimulus Cellular Response To Peptide Hormone Stimulus Response To Hormone Cellular Response To Peptide G-protein Coupled Receptor Signaling Pathway Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Digestion Proteolysis Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Macrophage Apoptotic Process Energy Reserve Metabolic Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cellular Response To Organic Substance Response To Organonitrogen Compound Insulin Processing Myeloid Cell Apoptotic Process Inflammatory Cell Apoptotic Process Insulin Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Cellular Response To Thyroid Hormone Stimulus Response To Organic Substance Cardiac Left Ventricle Morphogenesis Response To Thyroid Hormone Generation Of Precursor Metabolites And Energy CAMP-mediated Signaling Signal Transduction Cell Surface Receptor Signaling Pathway Response To Stimulus Activation Of Adenylate Cyclase Activity Cyclic-nucleotide-mediated Signaling Peptide Hormone Processing Signaling Response To Stress Positive Regulation Of Adenylate Cyclase Activity Cell Communication Regulation Of Glycogen Metabolic Process Toxin Transport	Response To Stimulus Blood Circulation G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Renal Sodium Excretion Regulation Of Ion Homeostasis Behavior Regulation Of Blood Pressure Cell Surface Receptor Signaling Pathway Regulation Of Renal Sodium Excretion Regulation Of Appetite Neuropeptide Signaling Pathway Regulation Of Excretion Feeding Behavior Signal Transduction Regulation Of Corticosterone Secretion Cell-cell Signaling Response To External Stimulus Regulation Of Cell Migration Signaling Regulation Of Cell Motility Secretion Cell Communication Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Locomotion Regulation Of Cellular Component Movement Cellular Homeostasis Regulation Of Neurological System Process Cellular Metal Ion Homeostasis Positive Regulation Of Transport Inflammatory Response Positive Regulation Of CAMP Biosynthetic Process Response To Nutrient Levels Cellular Cation Homeostasis Positive Regulation Of CAMP Metabolic Process Cellular Ion Homeostasis Single-organism Behavior Platelet Degranulation Response To Extracellular Stimulus Metal Ion Homeostasis Regulation Of Blood Vessel Size Regulation Of Tube Size Secretion By Cell Chemical Homeostasis Cellular Response To Stimulus Blood Vessel Development Regulation Of Cellular Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process
Tagcloud ?		abolishing ascribe cac carboxylate carboxylcytosine charged conflicts cytosine differently egr1 electrostatic favorably fc finger formylcytosine gggcg glutamine hmc hydroxymethylcytosine mc methylcytosine oxidized splice unmethylated unmodified unoxidized ways wilms wt1	accumulating anthropometric borderline carriers disturbances exonuclease fertility fluorogenic genbank gg gt hirsutism homa homeostatic hormonal hyperandrogenemia id obese ovary overweight pcos polycystic prominent rs17468190 taqman triglyceride tt utr variants
Tagcloud (Difference) ?		abolishing ascribe cac carboxylate carboxylcytosine charged conflicts cytosine differently egr1 electrostatic favorably fc finger formylcytosine gggcg glutamine hmc hydroxymethylcytosine mc methylcytosine oxidized splice unmethylated unmodified unoxidized ways wilms wt1	accumulating anthropometric borderline carriers disturbances exonuclease fertility fluorogenic genbank gg gt hirsutism homa homeostatic hormonal hyperandrogenemia id obese ovary overweight pcos polycystic prominent rs17468190 taqman triglyceride tt utr variants
Tagcloud (Intersection) ?