GCG and GLP2R

Number of citations of the paper that reports this interaction (PMID 11738243)
6

Data Source:
HPRD (in vivo, in vitro)

		GCG	GLP2R
Gene Name		glucagon	glucagon-like peptide 2 receptor
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Secretory Granule Lumen	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Receptor Binding Hormone Activity Protein Binding Glucagon Receptor Binding Identical Protein Binding	G-protein Coupled Receptor Activity Glucagon Receptor Activity
	Biological Process	Energy Reserve Metabolic Process Signal Transduction G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Feeding Behavior Cell Proliferation Protein Kinase A Signaling Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of Protein Binding Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Gluconeogenesis By Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Starvation Negative Regulation Of Apoptotic Process Cellular Protein Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Protein Kinase Activity Regulation Of Insulin Secretion Positive Regulation Of Histone H3-K4 Methylation Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Glucagon Stimulus Positive Regulation Of Calcium Ion Import Negative Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Cellular Response To Glucagon Stimulus
Pathways		G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Synthesis, secretion, and deacylation of Ghrelin Integration of energy metabolism G alpha (s) signalling events Regulation of insulin secretion Glucagon-type ligand receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding G alpha (q) signalling events Peptide hormone metabolism GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Class B/2 (Secretin family receptors) Glucagon signaling in metabolic regulation Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Incretin synthesis, secretion, and inactivation	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Glucagon-type ligand receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: CPE CTSL GCGR GLP1R GLP2R MEP1A MEP1B	2 interactors: CALM1 GCG
Entrez ID		2641	9340
HPRD ID		00676	04713
Ensembl ID		ENSG00000115263
Uniprot IDs		P01275	O95838
PDB IDs		1BH0 1D0R 1NAU 2G49 2L63 2L64 2M5P 2M5Q 3IOL
Enriched GO Terms of Interacting Partners?		Cellular Response To Glucagon Stimulus Response To Glucagon Cellular Response To Hormone Stimulus Cellular Response To Peptide Hormone Stimulus Response To Hormone Cellular Response To Peptide G-protein Coupled Receptor Signaling Pathway Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Digestion Proteolysis Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Macrophage Apoptotic Process Energy Reserve Metabolic Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cellular Response To Organic Substance Response To Organonitrogen Compound Insulin Processing Myeloid Cell Apoptotic Process Inflammatory Cell Apoptotic Process Insulin Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Cellular Response To Thyroid Hormone Stimulus Response To Organic Substance Cardiac Left Ventricle Morphogenesis Response To Thyroid Hormone Generation Of Precursor Metabolites And Energy CAMP-mediated Signaling Signal Transduction Cell Surface Receptor Signaling Pathway Response To Stimulus Activation Of Adenylate Cyclase Activity Cyclic-nucleotide-mediated Signaling Peptide Hormone Processing Signaling Response To Stress Positive Regulation Of Adenylate Cyclase Activity Cell Communication Regulation Of Glycogen Metabolic Process Toxin Transport	Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Ion Transmembrane Transport Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Positive Regulation Of Calcium Ion Transport Regulation Of CAMP Metabolic Process Energy Reserve Metabolic Process Regulation Of Calcium Ion Transport Positive Regulation Of Ion Transport Energy Derivation By Oxidation Of Organic Compounds Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Generation Of Precursor Metabolites And Energy Regulation Of Ion Transmembrane Transport Regulation Of High Voltage-gated Calcium Channel Activity Protein Kinase A Signaling Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Cellular Ketone Metabolic Process Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Gluconeogenesis By Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transferase Activity Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cellular Ketone Metabolic Process By Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Execution Phase Of Apoptosis Regulation Of Gluconeogenesis By Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Ion Transport Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Protein Phosphorylation Detection Of Calcium Ion Positive Regulation Of Transport Regulation Of Protein Kinase Activity Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Phosphoprotein Phosphatase Activity Regulation Of Kinase Activity Positive Regulation Of Calcium Ion Import Response To Organonitrogen Compound Positive Regulation Of Histone H3-K4 Methylation Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Glycogen Catabolic Process Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Positive Regulation Of Protein Modification Process Negative Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Gluconeogenesis Regulation Of Voltage-gated Calcium Channel Activity
Tagcloud ?		abolishing ascribe cac carboxylate carboxylcytosine charged conflicts cytosine differently egr1 electrostatic favorably fc finger formylcytosine gggcg glutamine hmc hydroxymethylcytosine mc methylcytosine oxidized splice unmethylated unmodified unoxidized ways wilms wt1	adaptation adaptive atrophy bowel crypt deprivation erbb exerts fasted fasting glucagon gut height histomorphometry igfr intestinal intestine jejunal kgf mucosal nutrients pan refed refeeding trophic undergoes villus weights
Tagcloud (Difference) ?		abolishing ascribe cac carboxylate carboxylcytosine charged conflicts cytosine differently egr1 electrostatic favorably fc finger formylcytosine gggcg glutamine hmc hydroxymethylcytosine mc methylcytosine oxidized splice unmethylated unmodified unoxidized ways wilms wt1	adaptation adaptive atrophy bowel crypt deprivation erbb exerts fasted fasting glucagon gut height histomorphometry igfr intestinal intestine jejunal kgf mucosal nutrients pan refed refeeding trophic undergoes villus weights
Tagcloud (Intersection) ?