GCG and GLP1R

Number of citations of the paper that reports this interaction (PMID 11116211)
11

Data Source:
HPRD (in vivo, in vitro)

		GCG	GLP1R
Gene Name		glucagon	glucagon-like peptide 1 receptor
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Secretory Granule Lumen	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Receptor Binding Hormone Activity Protein Binding Glucagon Receptor Binding Identical Protein Binding	Transmembrane Signaling Receptor Activity Glucagon Receptor Activity
	Biological Process	Energy Reserve Metabolic Process Signal Transduction G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Feeding Behavior Cell Proliferation Protein Kinase A Signaling Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of Protein Binding Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Gluconeogenesis By Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Starvation Negative Regulation Of Apoptotic Process Cellular Protein Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Protein Kinase Activity Regulation Of Insulin Secretion Positive Regulation Of Histone H3-K4 Methylation Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Glucagon Stimulus Positive Regulation Of Calcium Ion Import Negative Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Energy Reserve Metabolic Process Response To Stress G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Learning Or Memory Regulation Of Heart Contraction CAMP-mediated Signaling Small Molecule Metabolic Process Regulation Of Insulin Secretion Cellular Response To Glucagon Stimulus
Pathways		G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Synthesis, secretion, and deacylation of Ghrelin Integration of energy metabolism G alpha (s) signalling events Regulation of insulin secretion Glucagon-type ligand receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding G alpha (q) signalling events Peptide hormone metabolism GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Class B/2 (Secretin family receptors) Glucagon signaling in metabolic regulation Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Incretin synthesis, secretion, and inactivation	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Integration of energy metabolism G alpha (s) signalling events Regulation of insulin secretion Glucagon-type ligand receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs			Glucagon recombinant Exenatide Liraglutide
Diseases
GWAS
Protein-Protein Interactions		7 interactors: CPE CTSL GCGR GLP1R GLP2R MEP1A MEP1B	41 interactors: ACSF3 APH1A ARFRP1 ATP13A1 C14orf166 C18orf32 CALM1 CAND2 CEND1 CFI CYSTM1 ELOVL1 ERP29 GABBR2 GCG GPR37 GPRASP1 HPN IFITM3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 MFSD5 MRPL22 MYL6 NOTCH2NL NRGN NUCKS1 P4HTM PAQR6 PIGG SLC15A4 STMN1 STMN3 STOML2 SUMO1 SVOP SYNGR3 TMEM147 TSPAN13
Entrez ID		2641	2740
HPRD ID		00676	00677
Ensembl ID		ENSG00000115263	ENSG00000112164
Uniprot IDs		P01275	P43220
PDB IDs		1BH0 1D0R 1NAU 2G49 2L63 2L64 2M5P 2M5Q 3IOL	3C59 3C5T 3IOL
Enriched GO Terms of Interacting Partners?		Cellular Response To Glucagon Stimulus Response To Glucagon Cellular Response To Hormone Stimulus Cellular Response To Peptide Hormone Stimulus Response To Hormone Cellular Response To Peptide G-protein Coupled Receptor Signaling Pathway Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Digestion Proteolysis Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Macrophage Apoptotic Process Energy Reserve Metabolic Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cellular Response To Organic Substance Response To Organonitrogen Compound Insulin Processing Myeloid Cell Apoptotic Process Inflammatory Cell Apoptotic Process Insulin Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Cellular Response To Thyroid Hormone Stimulus Response To Organic Substance Cardiac Left Ventricle Morphogenesis Response To Thyroid Hormone Generation Of Precursor Metabolites And Energy CAMP-mediated Signaling Signal Transduction Cell Surface Receptor Signaling Pathway Response To Stimulus Activation Of Adenylate Cyclase Activity Cyclic-nucleotide-mediated Signaling Peptide Hormone Processing Signaling Response To Stress Positive Regulation Of Adenylate Cyclase Activity Cell Communication Regulation Of Glycogen Metabolic Process Toxin Transport	Microtubule Depolymerization Positive Regulation Of Peptidyl-threonine Phosphorylation Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Substantia Nigra Development Microtubule Polymerization Or Depolymerization Cerebellar Granular Layer Maturation Positive Regulation Of Cardiolipin Metabolic Process Protein Unfolding Positive Regulation Of Mitochondrial DNA Replication Stress-induced Mitochondrial Fusion Malonate Catabolic Process Molybdate Ion Transport
Tagcloud ?		abolishing ascribe cac carboxylate carboxylcytosine charged conflicts cytosine differently egr1 electrostatic favorably fc finger formylcytosine gggcg glutamine hmc hydroxymethylcytosine mc methylcytosine oxidized splice unmethylated unmodified unoxidized ways wilms wt1	2a cardiac cardiomyopathies cardioprotective ccaat chaperone chemoattractant chop endoplasmic ex4 exendin fibrosis glucagon gluco grp78 homologous incretin infarction infiltration lipotoxicity mcp1 mhc monocyte reperfusion reticulum sarco serca2a viable
Tagcloud (Difference) ?		abolishing ascribe cac carboxylate carboxylcytosine charged conflicts cytosine differently egr1 electrostatic favorably fc finger formylcytosine gggcg glutamine hmc hydroxymethylcytosine mc methylcytosine oxidized splice unmethylated unmodified unoxidized ways wilms wt1	2a cardiac cardiomyopathies cardioprotective ccaat chaperone chemoattractant chop endoplasmic ex4 exendin fibrosis glucagon gluco grp78 homologous incretin infarction infiltration lipotoxicity mcp1 mhc monocyte reperfusion reticulum sarco serca2a viable
Tagcloud (Intersection) ?