GCG and MEP1B

Number of citations of the paper that reports this interaction (PubMedID 11278902)
0

Data Source:
HPRD (in vitro)

		GCG	MEP1B
Description		glucagon	meprin A subunit beta
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Plasma Membrane Secretory Granule Lumen	Extracellular Region Extracellular Space Plasma Membrane Membrane Meprin A Complex
	Molecular Function	Signaling Receptor Binding Hormone Activity Protein Binding Gastric Inhibitory Polypeptide Receptor Binding Glucagon Receptor Binding Identical Protein Binding Receptor Ligand Activity	Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Gluconeogenesis G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Feeding Behavior Protein Kinase A Signaling Response To Activity Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Glucose Homeostasis Negative Regulation Of Apoptotic Process Positive Regulation Of Gluconeogenesis Regulation Of Insulin Secretion Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Glucagon Stimulus Positive Regulation Of Calcium Ion Import Negative Regulation Of Execution Phase Of Apoptosis	Proteolysis Inflammatory Response
Pathways		Glucagon signaling in metabolic regulation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) G alpha (q) signalling events G alpha (s) signalling events Glucagon-type ligand receptors Synthesis, secretion, and deacylation of Ghrelin
Drugs
Diseases
GWAS		Regular attendance at a pub or social club ( 29970889)	Metabolite levels ( 23823483) TRAIL levels ( 27989323)
Interacting Genes		7 interacting genes: CPE CTSL GCGR GLP1R GLP2R MEP1A MEP1B	13 interacting genes: CCK FN1 GAST GCG GRP MEP1A NPY OS9 PRKACA PRKCD PYY SCT TSPAN8
Entrez ID		2641	4225
HPRD ID		00676	02667
Ensembl ID		ENSG00000115263	ENSG00000141434
Uniprot IDs		P01275	J3QKX5 Q16820
PDB IDs		1BH0 1D0R 1NAU 2G49 2L63 2L64 2M5P 2M5Q 3IOL 4APD 4ZGM 5OTU 5OTV 5OTW 5OTX 5VAI 5YQZ 6EDS 6LMK 6LML 6NZN 6PHI 6PHJ 6PHK 6PHL 6PHO 6PHP 6VCB 6X18 7D68 7DUQ 7KI0 7KI1 7XM8 8ANJ 8ANK 8JRV 9IVG	4GWM 4GWN 7AQ1 7AUW
Enriched GO Terms of Interacting Partners?		Glucagon Receptor Activity Cellular Response To Glucagon Stimulus Response To Glucagon Meprin A Complex Peptide Hormone Processing Peptide Hormone Binding Signaling Receptor Ligand Precursor Processing Cellular Response To Hormone Stimulus Metallopeptidase Activity Peptidase Activity Regulation Of Hormone Levels Protein Processing Cellular Response To Peptide Hormone Stimulus Hormone Metabolic Process Response To Hormone Transmembrane Signaling Receptor Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Response To Peptide Hormone Protein Maturation Serpin Family Protein Binding Fusion Of Virus Membrane With Host Endosome Membrane Glucagon-like Peptide 1 Receptor Activity Plasma Membrane G Protein-coupled Receptor Activity Hormone Secretion Metalloendopeptidase Activity Enkephalin Processing Epidermal Growth Factor Receptor Ligand Maturation Hormone Transport Proteolysis Protein Localization To Secretory Granule Macrophage Apoptotic Process Elastin Catabolic Process Fusion Of Virus Membrane With Host Plasma Membrane Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Ribonucleoside-diphosphate Reductase Complex Chromaffin Granule Elastin Metabolic Process Endolysosome Lumen Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Response To Psychosocial Stress Signal Release Regulation Of Blood Pressure Inflammatory Cell Apoptotic Process Extracellular Space Regulation Of Biological Quality Ferric Iron Binding Post-translational Protein Targeting To Membrane, Translocation Metallodipeptidase Activity	Hormone Activity Neuropeptide Hormone Activity G Protein-coupled Receptor Signaling Pathway Extracellular Space Feeding Behavior Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Neuropeptide Y Receptor Binding Extracellular Region Positive Regulation Of Hormone Secretion Signaling Receptor Binding Signal Transduction Regulation Of Peptide Hormone Secretion Regulation Of Biological Quality G Protein-coupled Receptor Binding Regulation Of Hormone Levels Cellular Response To Glucagon Stimulus Intestinal Epithelial Cell Differentiation Regulation Of Hormone Secretion Regulation Of Secretion By Cell Regulation Of Body Fluid Levels Regulation Of Transport Positive Regulation Of Secretion By Cell Neuropeptide Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Secretion Positive Regulation Of Secretion Response To Glucagon Receptor Ligand Activity Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Gluconeogenesis Regulation Of Appetite Positive Regulation Of Lipid Metabolic Process Regulation Of Intracellular Protein Transport Positive Regulation Of Lipid Catabolic Process Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Behavior Positive Regulation Of Transport Regulation Of Protein Transport Cellular Response To Peptide Hormone Stimulus Peptidyl-serine Phosphorylation Regulation Of Cellular Localization Regulation Of Establishment Of Protein Localization Positive Regulation Of Glucose Metabolic Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Gluconeogenesis Short-day Photoperiodism Negative Regulation Of Coagulation
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