GCG and CPE

Number of citations of the paper that reports this interaction (PMID 11375130)
3

Data Source:
HPRD (in vivo)

		GCG	CPE
Gene Name		glucagon	carboxypeptidase E
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Secretory Granule Lumen	Nucleus Golgi Apparatus Plasma Membrane Transport Vesicle Membrane Secretory Granule Membrane Extracellular Vesicular Exosome
	Molecular Function	Receptor Binding Hormone Activity Protein Binding Glucagon Receptor Binding Identical Protein Binding	Carboxypeptidase Activity Metallocarboxypeptidase Activity Zinc Ion Binding Neurexin Family Protein Binding Cell Adhesion Molecule Binding
	Biological Process	Energy Reserve Metabolic Process Signal Transduction G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Feeding Behavior Cell Proliferation Protein Kinase A Signaling Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of Protein Binding Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Gluconeogenesis By Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Starvation Negative Regulation Of Apoptotic Process Cellular Protein Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Protein Kinase Activity Regulation Of Insulin Secretion Positive Regulation Of Histone H3-K4 Methylation Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Glucagon Stimulus Positive Regulation Of Calcium Ion Import Negative Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Cardiac Left Ventricle Morphogenesis Cellular Protein Modification Process Proteolysis Neuropeptide Signaling Pathway Metabolic Process Insulin Processing Cellular Protein Metabolic Process Protein Localization To Membrane
Pathways		G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Synthesis, secretion, and deacylation of Ghrelin Integration of energy metabolism G alpha (s) signalling events Regulation of insulin secretion Glucagon-type ligand receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding G alpha (q) signalling events Peptide hormone metabolism GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Class B/2 (Secretin family receptors) Glucagon signaling in metabolic regulation Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Incretin synthesis, secretion, and inactivation	Peptide hormone metabolism Insulin processing
Drugs			Insulin Regular Insulin, porcine
Diseases
GWAS
Protein-Protein Interactions		7 interactors: CPE CTSL GCGR GLP1R GLP2R MEP1A MEP1B	17 interactors: BDNF CCK CHD3 GAST GCG GTF3C1 INS LRIF1 MED31 NTS PMCH POLA2 POLDIP2 ROBO2 RPA1 TRH UTP14A
Entrez ID		2641	1363
HPRD ID		00676	00272
Ensembl ID		ENSG00000115263	ENSG00000109472
Uniprot IDs		P01275	P16870
PDB IDs		1BH0 1D0R 1NAU 2G49 2L63 2L64 2M5P 2M5Q 3IOL
Enriched GO Terms of Interacting Partners?		Cellular Response To Glucagon Stimulus Response To Glucagon Cellular Response To Hormone Stimulus Cellular Response To Peptide Hormone Stimulus Response To Hormone Cellular Response To Peptide G-protein Coupled Receptor Signaling Pathway Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Digestion Proteolysis Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Macrophage Apoptotic Process Energy Reserve Metabolic Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cellular Response To Organic Substance Response To Organonitrogen Compound Insulin Processing Myeloid Cell Apoptotic Process Inflammatory Cell Apoptotic Process Insulin Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Cellular Response To Thyroid Hormone Stimulus Response To Organic Substance Cardiac Left Ventricle Morphogenesis Response To Thyroid Hormone Generation Of Precursor Metabolites And Energy CAMP-mediated Signaling Signal Transduction Cell Surface Receptor Signaling Pathway Response To Stimulus Activation Of Adenylate Cyclase Activity Cyclic-nucleotide-mediated Signaling Peptide Hormone Processing Signaling Response To Stress Positive Regulation Of Adenylate Cyclase Activity Cell Communication Regulation Of Glycogen Metabolic Process Toxin Transport	Feeding Behavior Negative Regulation Of Feeding Behavior Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Behavior Regulation Of Feeding Behavior Positive Regulation Of Hormone Secretion Telomere Maintenance Via Semi-conservative Replication G-protein Coupled Receptor Signaling Pathway Nuclear DNA Replication Telomere Maintenance Via Recombination Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Protein Oligomerization Mitotic Recombination DNA Strand Elongation Involved In DNA Replication Eating Behavior DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Glucose Metabolic Process Regulation Of Behavior Behavioral Fear Response Neuron Recognition Positive Regulation Of Protein Secretion Regulation Of Cellular Ketone Metabolic Process Regulation Of Insulin Secretion Fear Response Response To Hormone Regulation Of Peptide Hormone Secretion Regulation Of Gluconeogenesis Cellular Response To Hormone Stimulus Response To Anesthetic Response To Fluoxetine Response To L-glutamate Regulation Of Hormone Secretion Regulation Of Synapse Assembly Positive Regulation Of Insulin Secretion Energy Derivation By Oxidation Of Organic Compounds Positive Regulation Of Protein Phosphorylation Positive Regulation Of Peptidyl-serine Phosphorylation Telomere Maintenance Positive Regulation Of Secretion Negative Regulation Of Glycogen Catabolic Process Negative Regulation Of Negative Chemotaxis Positive Regulation Of Protein Transport Multicellular Organismal Response To Stress Regulation Of Synapse Organization Regulation Of Synapse Structure Or Activity Taste Bud Development Apoptotic Process Involved In Luteolysis Dendrite Extension
Tagcloud ?		abolishing ascribe cac carboxylate carboxylcytosine charged conflicts cytosine differently egr1 electrostatic favorably fc finger formylcytosine gggcg glutamine hmc hydroxymethylcytosine mc methylcytosine oxidized splice unmethylated unmodified unoxidized ways wilms wt1	attenuating chimera chimeras cytopathic flanked glycoproteins hamsters hemagglutinin hn illustrated lies llc measles neuraminidase noncytopathic nontranslated noteworthy parainfluenza parent piv1 piv2 piv3 presumed replicates resembles rpiv3 somatitis staged virion
Tagcloud (Difference) ?		abolishing ascribe cac carboxylate carboxylcytosine charged conflicts cytosine differently egr1 electrostatic favorably fc finger formylcytosine gggcg glutamine hmc hydroxymethylcytosine mc methylcytosine oxidized splice unmethylated unmodified unoxidized ways wilms wt1	attenuating chimera chimeras cytopathic flanked glycoproteins hamsters hemagglutinin hn illustrated lies llc measles neuraminidase noncytopathic nontranslated noteworthy parainfluenza parent piv1 piv2 piv3 presumed replicates resembles rpiv3 somatitis staged virion
Tagcloud (Intersection) ?