PIAS3 and GFI1

Number of citations of the paper that reports this interaction (PubMedID 11060035)
42

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		PIAS3	GFI1
Description		protein inhibitor of activated STAT 3	growth factor independent 1 transcriptional repressor
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Speck Glutamatergic Synapse Presynaptic Cytosol Postsynaptic Cytosol	Nucleus Nuclear Matrix Nuclear Body Transcription Repressor Complex
	Molecular Function	Transcription Coregulator Activity Protein Binding Zinc Ion Binding Transferase Activity SUMO Transferase Activity Metal Ion Binding SUMO Ligase Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding Enzyme-substrate Adaptor Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Expression Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Sumoylation Negative Regulation Of Protein Sumoylation Positive Regulation Of Protein Sumoylation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Via Homologous Recombination Regulation Of Transcription By RNA Polymerase II DNA Damage Response Negative Regulation Of Vitamin D Biosynthetic Process Negative Regulation Of Neuron Projection Development Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of Interleukin-6-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		SUMOylation of transcription factors SUMOylation of transcription cofactors SUMOylation of intracellular receptors SUMOylation of DNA replication proteins SUMOylation of immune response proteins Formation of Incision Complex in GG-NER	Transcriptional regulation of granulopoiesis
Drugs
Diseases
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29785011) Multiple sclerosis ( 31604244) Multiple sclerosis and type 2 diabetes (pleiotropy) ( 26920376) Systemic lupus erythematosus ( 28714469) Total cholesterol levels ( 33339817)
Interacting Genes		61 interacting genes: AR ATF7IP CARHSP1 CBS CREBBP CREM EP300 ERG ESR1 ESR2 FOXP2 GEMIN4 GFI1 GLUL HABP4 HDAC1 HMGA2 MITF MORC3 NCOA2 NR3C2 NRIP1 OPN1LW PGR PLIN3 PPP1CA PRPF40A PSMC1 RAC1 RELA REX1BD SATB1 SENP1 SERBP1 SERPINA10 SIAH1 SIAH2 SKIL SMAD2 SMAD3 SMAD4 SNAI2 SNCA SNIP1 SPOP SREBF2 STAT3 STIP1 SUMO1 SUMO2 SUMO3 TBP TRIM27 TRIM32 TRIM55 TRIM63 UBA1 UBE2I ZFHX3 ZMIZ1 ZMIZ2	6 interacting genes: FBXW7 GSK3B PIAS3 PICK1 RUNX1T1 SPI1
Entrez ID		10401	2672
HPRD ID		09068	07527
Ensembl ID		ENSG00000131788	ENSG00000162676
Uniprot IDs		B3KNI3 Q9Y6X2	Q99684
PDB IDs		4MVT
Enriched GO Terms of Interacting Partners?		Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Nucleus Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Chromatin Negative Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Nucleoplasm Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Gene Expression RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Regulator Complex Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Enzyme Binding DNA-binding Transcription Factor Activity Transcription Coactivator Binding Protein Sumoylation Positive Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Cis-regulatory Region Binding Positive Regulation Of Biosynthetic Process Estrogen Response Element Binding Positive Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Chromatin Binding Rhythmic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific SMAD Protein Complex PML Body Sequence-specific DNA Binding Regulation Of MiRNA Transcription Nuclear Steroid Receptor Activity Protein Modification By Small Protein Conjugation	Negative Regulation Of Developmental Process Positive Regulation Of Post-translational Protein Modification Maintenance Of Cell Polarity Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Protein Modification Process Regulation Of Myeloid Cell Differentiation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of Cell Differentiation Negative Regulation Of Macromolecule Metabolic Process Regulation Of Developmental Process Neuron Projection Organization Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Development Negative Regulation Of Cell Communication Regulation Of Post-translational Protein Modification Negative Regulation Of Myeloid Leukocyte Differentiation Regulation Of Cell Differentiation Positive Regulation Of Protein Metabolic Process Vasculature Development Regulation Of Cell Development SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Regulation Of Protein Localization Regulation Of Microtubule Anchoring At Centrosome Renal Phosphate Ion Absorption Regulation Of Osteoclast Differentiation Negative Regulation Of Catabolic Process Positive Regulation Of Protein Modification Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Apoptotic Signaling Pathway G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of Primary Metabolic Process Superior Temporal Gyrus Development Negative Regulation Of Type B Pancreatic Cell Development Establishment Of Cell Polarity Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Myeloid Dendritic Cell Chemotaxis Pro-T Cell Differentiation Negative Regulation Of Neutrophil Degranulation
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