PIAS3 and ATF7IP

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
HPRD (two hybrid)

		PIAS3	ATF7IP
Gene Name		protein inhibitor of activated STAT, 3	activating transcription factor 7 interacting protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Dendrite Synapse	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm
	Molecular Function	Protein Binding Protein C-terminus Binding Zinc Ion Binding Potassium Channel Regulator Activity Ligase Activity SUMO Transferase Activity Enzyme Binding Protein N-terminus Binding	Transcription Corepressor Activity Protein Binding ATPase Activity
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Response To Hormone Positive Regulation Of Gene Expression Protein Sumoylation Positive Regulation Of Protein Sumoylation Positive Regulation Of Membrane Potential	Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA Methylation Chromatin Organization Transcription, DNA-templated Viral Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly
Pathways			Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines
Drugs
Diseases
GWAS			Prostate-specific antigen levels ( 23359319) Testicular germ cell cancer ( 20543847) Testicular germ cell tumor ( 23666240)
Protein-Protein Interactions		49 interactors: AR ATF7IP C19orf60 CARHSP1 CBS CREM EP300 ESR1 ESR2 GEMIN4 GFI1 GLUL HABP4 HDAC1 HMGA2 MITF NCOA2 NR3C2 OPN1LW PGR PPP1CA PRPF40A PSMC1 RAC1 RELA SATB1 SERBP1 SERPINA10 SIAH1 SIAH2 SKIL SMAD2 SMAD3 SMAD4 SREBF2 STAT3 SUMO1 SUMO2 SUMO3 TBP TRIM27 TRIM32 TRIM55 TRIM63 UBA1 UBE2I ZFHX3 ZMIZ1 ZMIZ2	68 interactors: A2M ACTB ACTG1 AP1B1 CADM1 CEP250 COL4A2 CREB1 CSPG4 DISC1 DMTF1 DNM2 EPG5 FLNB FLT4 GMEB1 GTF2E2 GTF2F1 GTF2H1 HEYL HLA-B HSPG2 KIF13A KRT7 LAMA4 LAMA5 LAMC1 LUC7L2 MACF1 MBD1 MCAM MED4 MRI1 NOMO1 NPR1 PAPPA PAPPA2 PCDH1 PEX6 PIAS3 PKD1 PLEKHB2 POLR2C POLR2D POLR2G PRSS8 PSG3 QRICH1 RPS3A RRBP1 SENP3 SETDB1 SLC12A4 SMAD4 SP1 SPTBN1 SREBF2 STBD1 STRN SUMO3 SUSD1 SVEP1 TRIP12 TTC3 UBE2I ZBTB6 ZNF350 ZNF518A
Entrez ID		10401	55729
HPRD ID		09068	09811
Ensembl ID		ENSG00000131788	ENSG00000171681
Uniprot IDs		B3KNI3 Q6IAR4 Q9Y6X2	B3KNI7 B3KQF8 F5GX74 G3V1U0 Q6VMQ6
PDB IDs			2RPQ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Metabolic Process Gene Expression Transcription Initiation From RNA Polymerase II Promoter RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process DNA-templated Transcription, Initiation Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Cellular Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Response To Organic Substance Regulation Of Cellular Process Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Viral Process Cellular Response To Organic Substance Biosynthetic Process Epithelium Development Regulation Of Signal Transduction Regulation Of Cell Death Regulation Of Signaling Response To Stimulus Cellular Response To Stimulus	Transcription Initiation From RNA Polymerase II Promoter Viral Process Positive Regulation Of Viral Transcription Cell Differentiation DNA-templated Transcription, Initiation Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Regulation Of Viral Transcription 7-methylguanosine RNA Capping Positive Regulation Of Viral Process Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Elongation RNA Biosynthetic Process Developmental Process Transcription, DNA-templated Anatomical Structure Development Regulation Of Viral Process Post-Golgi Vesicle-mediated Transport Macromolecule Biosynthetic Process Transcription-coupled Nucleotide-excision Repair Gene Expression RNA Metabolic Process Extracellular Matrix Disassembly Cellular Macromolecule Biosynthetic Process Anatomical Structure Morphogenesis System Development Cell Junction Assembly Cardiovascular System Development Stem Cell Differentiation Anatomical Structure Formation Involved In Morphogenesis Biosynthetic Process Nervous System Development Neurogenesis Angiogenesis Positive Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Golgi To Plasma Membrane Protein Transport Somatic Stem Cell Maintenance Protein Sumoylation Positive Regulation Of Gene Expression Multicellular Organismal Development Generation Of Neurons Stem Cell Development Blood Vessel Development Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Cellular Biosynthetic Process Nucleobase-containing Compound Metabolic Process Axon Guidance Golgi Vesicle Transport Vasculature Development
Tagcloud ?		achieved atm atr consistently crucial dbc1 deficient diverse establish etoposide finely genotoxic interaction knockdown metabolism modification modifier promoted promotion remarkably senp1 sirt1 sumo sumo1 sumo2 sumoylation switching transactivation ubiquitin	acgh adherent cce cd15 cd29 cd44 cd90 continuously csmd1 cultivation cytokeratins cytometric devastating doubling explant grin2b hypercalcemia hypercalcemic karyotype lentiviral oligo outgrowth paralleled park2 proliferating sccoht similarities subpopulations vimentin
Tagcloud (Difference) ?		achieved atm atr consistently crucial dbc1 deficient diverse establish etoposide finely genotoxic interaction knockdown metabolism modification modifier promoted promotion remarkably senp1 sirt1 sumo sumo1 sumo2 sumoylation switching transactivation ubiquitin	acgh adherent cce cd15 cd29 cd44 cd90 continuously csmd1 cultivation cytokeratins cytometric devastating doubling explant grin2b hypercalcemia hypercalcemic karyotype lentiviral oligo outgrowth paralleled park2 proliferating sccoht similarities subpopulations vimentin
Tagcloud (Intersection) ?