PIAS3 and OPN1LW

Number of citations of the paper that reports this interaction (PubMedID 14691252)
52

Data Source:
HPRD (in vivo, in vitro)

		PIAS3	OPN1LW
Description		protein inhibitor of activated STAT 3	opsin 1, long wave sensitive
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Speck Glutamatergic Synapse Presynaptic Cytosol Postsynaptic Cytosol	Photoreceptor Outer Segment Plasma Membrane Membrane Photoreceptor Disc Membrane
	Molecular Function	Transcription Coregulator Activity Protein Binding Zinc Ion Binding Transferase Activity SUMO Transferase Activity Metal Ion Binding SUMO Ligase Activity	G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Photoreceptor Activity Photoreceptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Expression Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Sumoylation Negative Regulation Of Protein Sumoylation Positive Regulation Of Protein Sumoylation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Visual Perception Phototransduction Detection Of Visible Light Absorption Of Visible Light Positive Regulation Of Cytokinesis Cellular Response To Light Stimulus
Pathways		SUMOylation of transcription factors SUMOylation of transcription cofactors SUMOylation of intracellular receptors SUMOylation of DNA replication proteins SUMOylation of immune response proteins Formation of Incision Complex in GG-NER	The retinoid cycle in cones (daylight vision) G alpha (i) signalling events Opsins Defective visual phototransduction due to OPN1LW loss of function
Drugs
Diseases			Blue cone monochromacy Colorblindness, including: Dichromacy; Anomalous trichromacy
GWAS			Lymphocyte count ( 32888494)
Interacting Genes		61 interacting genes: AR ATF7IP CARHSP1 CBS CREBBP CREM EP300 ERG ESR1 ESR2 FOXP2 GEMIN4 GFI1 GLUL HABP4 HDAC1 HMGA2 MITF MORC3 NCOA2 NR3C2 NRIP1 OPN1LW PGR PLIN3 PPP1CA PRPF40A PSMC1 RAC1 RELA REX1BD SATB1 SENP1 SERBP1 SERPINA10 SIAH1 SIAH2 SKIL SMAD2 SMAD3 SMAD4 SNAI2 SNCA SNIP1 SPOP SREBF2 STAT3 STIP1 SUMO1 SUMO2 SUMO3 TBP TRIM27 TRIM32 TRIM55 TRIM63 UBA1 UBE2I ZFHX3 ZMIZ1 ZMIZ2	6 interacting genes: NCOA2 NRM PIAS3 RANBP2 TICAM2 TRARG1
Entrez ID		10401	5956
HPRD ID		09068	02366
Ensembl ID		ENSG00000131788	ENSG00000102076
Uniprot IDs		B3KNI3 Q9Y6X2	P04000
PDB IDs		4MVT	8IU2
Enriched GO Terms of Interacting Partners?		Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Nucleus Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Chromatin Negative Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Nucleoplasm Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Gene Expression RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Regulator Complex Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Enzyme Binding DNA-binding Transcription Factor Activity Transcription Coactivator Binding Protein Sumoylation Positive Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Cis-regulatory Region Binding Positive Regulation Of Biosynthetic Process Estrogen Response Element Binding Positive Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Chromatin Binding Rhythmic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific SMAD Protein Complex PML Body Sequence-specific DNA Binding Regulation Of MiRNA Transcription Nuclear Steroid Receptor Activity Protein Modification By Small Protein Conjugation	SUMO Ligase Activity SUMO Transferase Activity Toll-like Receptor Signaling Pathway Regulation Of Small Molecule Metabolic Process Protein Sumoylation Innate Immune Response-activating Signaling Pathway Annulate Lamellae Negative Regulation Of Immune System Process Cytoplasmic Periphery Of The Nuclear Pore Complex Pattern Recognition Receptor Signaling Pathway Negative Regulation Of RNA Export From Nucleus SUMO Ligase Complex Regulation Of Glucose Metabolic Process Nuclear Pore Cytoplasmic Filaments Regulation Of Cardiolipin Metabolic Process Cardiolipin Acyl-chain Remodeling 1-acylglycerophosphocholine O-acyltransferase Activity Positive Regulation Of Cardiolipin Metabolic Process Transcription Coregulator Activity Regulation Of Cytokine-mediated Signaling Pathway Cellular Response To Thyroglobulin Triiodothyronine Response To Thyroglobulin Triiodothyronine Glucose Import In Response To Insulin Stimulus Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Interleukin-18-mediated Signaling Pathway Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production TRAM-dependent Toll-like Receptor 4 Signaling Pathway Activation Of Innate Immune Response Nuclear Envelope RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding Aryl Hydrocarbon Receptor Binding Intracellular Receptor Signaling Pathway Nuclear Pore Nuclear Basket Nuclear Inclusion Body Kinase Activator Activity Nuclear Membrane Cardiolipin Metabolic Process Positive Regulation Of ATP Biosynthetic Process Cristae Formation Negative Regulation Of Protein Sumoylation Positive Regulation Of Protein Sumoylation Locomotor Rhythm Peroxisome Proliferator Activated Receptor Signaling Pathway Positive Regulation Of Adipose Tissue Development Endosome To Plasma Membrane Protein Transport Vesicle Fusion To Plasma Membrane MyD88-independent Toll-like Receptor Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway
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