PIAS3 and SNAI2

Number of citations: 69 (PubMedID 30612578)
Data Source: BioGRID (pull down)

		PIAS3	SNAI2
Name		protein inhibitor of activated STAT 3	snail family transcriptional repressor 2
Structure			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Speck Glutamatergic Synapse Presynaptic Cytosol Postsynaptic Cytosol	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Transcription Coregulator Activity Protein Binding Zinc Ion Binding Transferase Activity SUMO Transferase Activity Metal Ion Binding SUMO Ligase Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding E-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Expression Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Sumoylation Negative Regulation Of Protein Sumoylation Positive Regulation Of Protein Sumoylation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Epithelial To Mesenchymal Transition Aortic Valve Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Cell Migration Involved In Endocardial Cushion Formation Chromatin Organization Regulation Of DNA-templated Transcription Substrate-dependent Cell Migration Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Notch Signaling Pathway Sensory Perception Of Sound Response To Radiation Epithelial Cell Migration Negative Regulation Of Keratinocyte Proliferation Negative Regulation Of Vitamin D Biosynthetic Process Neural Crest Cell Development Positive Regulation Of Cell Migration Negative Regulation Of Chondrocyte Differentiation Regulation Of Chemokine Production Myeloid Cell Apoptotic Process Negative Regulation Of Myeloid Cell Apoptotic Process Negative Regulation Of Cell Adhesion Mediated By Integrin Desmosome Disassembly Pigmentation Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Endothelial Cell Migration Positive Regulation Of Fat Cell Differentiation Regulation Of Osteoblast Differentiation Mesenchymal Cell Differentiation White Fat Cell Differentiation Roof Of Mouth Development Epithelium Development Cartilage Morphogenesis Regulation Of Branching Involved In Salivary Gland Morphogenesis Negative Regulation Of Vitamin D Receptor Signaling Pathway Cellular Response To Epidermal Growth Factor Stimulus Hematopoietic Stem Cell Proliferation Cellular Response To Ionizing Radiation Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Hematopoietic Stem Cell Proliferation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Bicellular Tight Junction Assembly Negative Regulation Of Anoikis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		SUMOylation of transcription factors SUMOylation of transcription cofactors SUMOylation of intracellular receptors SUMOylation of DNA replication proteins SUMOylation of immune response proteins Formation of Incision Complex in GG-NER	Regulation of PTEN gene transcription Regulation of PTEN gene transcription Negative Regulation of CDH1 Gene Transcription Transcriptional and post-translational regulation of MITF-M expression and activity
Diseases		None	Waardenburg syndrome (WS) Piebaldism
GWAS		No GWAS studies recorded	Hip index ( 34021172 )
Interacting Genes		61 interacting genes: AR ATF7IP CARHSP1 CBS CREBBP CREM EP300 ERG ESR1 ESR2 FOXP2 GEMIN4 GFI1 GLUL HABP4 HDAC1 HMGA2 MITF MORC3 NCOA2 NR3C2 NRIP1 OPN1LW PGR PLIN3 PPP1CA PRPF40A PSMC1 RAC1 RELA REX1BD SATB1 SENP1 SERBP1 SERPINA10 SIAH1 SIAH2 SKIL SMAD2 SMAD3 SMAD4 SNAI2 SNCA SNIP1 SPOP SREBF2 STAT3 STIP1 SUMO1 SUMO2 SUMO3 TBP TRIM27 TRIM32 TRIM55 TRIM63 UBA1 UBE2I ZFHX3 ZMIZ1 ZMIZ2	14 interacting genes: APP CABP2 CREBBP CSNK2A1 FBXO28 FBXO45 PIAS1 PIAS2 PIAS3 PIAS4 SAT1 TRIM23 UBE2I ZNF76
Entrez ID		10401	6591
HPRD ID		09068	03689
Ensembl ID		ENSG00000131788	ENSG00000019549
Uniprot IDs		B3KNI3 Q9Y6X2	O43623
PDB IDs		4MVT	Not available
GO Terms Enriched among Interactors		Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Nucleus Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Chromatin Negative Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Nucleoplasm Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Gene Expression RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Regulator Complex Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Enzyme Binding DNA-binding Transcription Factor Activity Transcription Coactivator Binding Protein Sumoylation Positive Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Cis-regulatory Region Binding Positive Regulation Of Biosynthetic Process Estrogen Response Element Binding Positive Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Chromatin Binding Rhythmic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific SMAD Protein Complex PML Body Sequence-specific DNA Binding Regulation Of MiRNA Transcription Nuclear Steroid Receptor Activity Protein Modification By Small Protein Conjugation	SUMO Transferase Activity SUMO Ligase Activity Protein Sumoylation Post-translational Protein Modification Presynaptic Cytosol Postsynaptic Cytosol PML Body Protein Modification By Small Protein Conjugation Transcription Coregulator Activity Positive Regulation Of Protein Sumoylation Regulation Of Protein Sumoylation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification Process Protein Metabolic Process Transferase Activity Negative Regulation Of Macromolecule Biosynthetic Process Transcription Corepressor Activity Negative Regulation Of Biosynthetic Process Double-strand Break Repair Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Macromolecule Metabolic Process Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Transcription By RNA Polymerase II Transferase Complex Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Catabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Metal Ion Binding Positive Regulation Of Post-translational Protein Modification Double-strand Break Repair Via Homologous Recombination Negative Regulation Of DNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA Recombination Recombinational Repair Regulation Of Double-strand Break Repair Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA Damage Response Positive Regulation Of Protein Metabolic Process Negative Regulation Of Double-strand Break Repair Zinc Ion Binding Negative Regulation Of DNA Repair Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of DNA Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium