DOK7 and EFHC1

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		DOK7	EFHC1
Description		docking protein 7	EF-hand domain containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Plasma Membrane Membrane Neuromuscular Junction Synapse Postsynaptic Membrane	Spindle Pole Cytoplasm Centrosome Spindle Cytoskeleton Axonemal Microtubule Cilium Axoneme Motile Cilium Sperm Flagellum Cell Projection Neuronal Cell Body Mitotic Spindle Axonemal A Tubule Inner Sheath
	Molecular Function	Protein Binding Lipid Binding Protein Kinase Binding Phosphatidylinositol Binding Signaling Adaptor Activity	Calcium Ion Binding Protein Binding Alpha-tubulin Binding
	Biological Process	Enzyme-linked Receptor Protein Signaling Pathway Neuromuscular Junction Development Positive Regulation Of Rac Protein Signal Transduction Receptor Clustering Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering	Mitotic Cytokinesis Mitotic Spindle Organization Cerebral Cortex Cell Migration Flagellated Sperm Motility Regulation Of Cell Division Cilium-dependent Cell Motility
Pathways
Drugs
Diseases		Congenital myasthenic syndrome Fetal akinesia deformation sequence (FADS); Pena-Shokeir syndrome, type 1	Idiopathic generalied epilepsies (IGEs), including: Childhood absence epilepsy (CAE); Juvenile absence epilepsy (JAE); Juvenile myoclonic epilepsy (JME); Epilepsy with generalized tonic-clonic seizures alone
GWAS		Calcium levels ( 29403010) Coronary artery disease ( 33020668) Fibrinogen levels ( 28107422) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 31562340) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Spondylosis ( 33332786)	Atopic march ( 26542096) Clozapine-induced myocarditis in schizophrenia ( 32066683) Mean platelet volume ( 27863252) Perceived intensity of glucose ( 31005972) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) White blood cell count ( 32888494)
Interacting Genes		8 interacting genes: APPL1 BCAR1 CRK EFEMP2 EFHC1 MPZL1 MUSK YPEL3	68 interacting genes: AKT1 CACNA1E CALCOCO2 CFAP161 CHCHD3 CIMIP1 DOK7 EFHC2 EIF4ENIF1 FMR1 GADD45B GAS2L2 GOLGA2 HOMER3 IHO1 IKZF3 IMP3 ITGB3BP KCNJ5-AS1 KCTD4 KRT15 KRT18 KRT75 LMO2 LRRC61 MAMDC2 MBD3L1 METTL27 MIIP MRNIP MTFR1L NQO2 NRIP3 NUP54 OIP5 PAX6 PBX1 PBX2 PMF1 PRR5L RCN1 REL RIMBP3 RNF125 SAPCD1 SELENOV SH3GLB2 SLAIN1 SNAI1 SORBS3 SPATA2 SYNGAP1 TCF4 TEKT1 TEX11 TLE5 TP53BP2 TRAF2 TRIP6 TRPM2 TSGA10IP TTC23L UBAP2 VBP1 WASF1 WHRN YJU2B ZBED1
Entrez ID		285489	114327
HPRD ID		08744	10583
Ensembl ID		ENSG00000175920	ENSG00000096093
Uniprot IDs		A0A1W2PRA3 A0A2R8Y701 Q18PE1 Q8N1M3	B2CKC5 Q5JVL4
PDB IDs			7UNG 8J07
Enriched GO Terms of Interacting Partners?		Response To Hepatocyte Growth Factor Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cellular Response To Hepatocyte Growth Factor Stimulus Cellular Response To Growth Factor Stimulus Actin Cytoskeleton Response To Growth Factor Positive Regulation Of Protein Geranylgeranylation Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Smooth Muscle Cell-matrix Adhesion Neuromuscular Junction Insulin Receptor Signaling Pathway Helper T Cell Diapedesis Cell Surface Receptor Signaling Pathway Protein Phosphorylated Amino Acid Binding Response To Cholecystokinin Positive Regulation Of Macropinocytosis Positive Regulation Of Aortic Smooth Muscle Cell Differentiation Ruffle SH3 Domain Binding Cerebellar Neuron Development Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Collagen Fibril Organization Regulation Of Smooth Muscle Cell-matrix Adhesion Regulation Of Growth Regulation Of Cellular Component Organization Macropinosome Elastic Fiber Regulation Of Protein Localization To Membrane Aorta Smooth Muscle Tissue Morphogenesis Diapedesis Positive Regulation Of Pinocytosis Cell Chemotaxis Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Receptor Clustering Cellular Response To Insulin-like Growth Factor Stimulus Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Reelin-mediated Signaling Pathway Response To Endothelin Cellular Response To Endothelin Regulation Of Cell-substrate Adhesion Postsynaptic Specialization Assembly Skeletal Muscle Acetylcholine-gated Channel Clustering Regulation Of Synaptic Assembly At Neuromuscular Junction Endothelin Receptor Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Early Phagosome Positive Regulation Of Melanin Biosynthetic Process Protein Kinase B Binding Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway	Protein Binding
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