GPC3

Gene Name		glypican 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Proteinaceous Extracellular Matrix Extracellular Space Golgi Lumen Plasma Membrane Integral Component Of Plasma Membrane Lysosomal Lumen Anchored Component Of Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Heparan Sulfate Proteoglycan Binding Peptidyl-dipeptidase Inhibitor Activity
	Biological Process	Retinoid Metabolic Process Branching Involved In Ureteric Bud Morphogenesis Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Phototransduction, Visible Light Pathogenesis Anatomical Structure Morphogenesis Anterior/posterior Axis Specification Body Morphogenesis Negative Regulation Of Peptidase Activity Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Bone Mineralization Osteoclast Differentiation Lung Development Positive Regulation Of BMP Signaling Pathway Embryonic Hindlimb Morphogenesis Small Molecule Metabolic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Endocytosis Negative Regulation Of Smoothened Signaling Pathway Positive Regulation Of Smoothened Signaling Pathway Negative Regulation Of Growth Positive Regulation Of Glucose Import Negative Regulation Of Epithelial Cell Proliferation Coronary Vasculature Development Mesenchymal Cell Proliferation Involved In Ureteric Bud Development Mesonephric Duct Morphogenesis Cell Proliferation Involved In Metanephros Development Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway
Pathways		MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type Heparan sulfate/heparin (HS-GAG) metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis MPS IIIC - Sanfilippo syndrome C Retinoid metabolism and transport Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS Diseases associated with visual transduction MPS IV - Morquio syndrome A Visual phototransduction MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome Metabolism of carbohydrates HS-GAG biosynthesis HS-GAG degradation MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS
Protein-protein Interactions		4 interactors: FGF2 IGF2 WNT3A WNT7B
Entrez ID		2719
HPRD ID		02074
Ensembl ID		ENSG00000147257
Uniprot IDs		B4DTD8 I6QTG3 P51654 Q53H15
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Cell Fate Specification Positive Regulation Of Transferase Activity Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Positive Regulation Of Cell Proliferation Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Positive Regulation Of Cell Fate Commitment Organ Morphogenesis Regulation Of Cell Fate Specification Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Muscle Cell Differentiation Regulation Of Cell Fate Commitment Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Epithelial Tube Morphogenesis Positive Regulation Of Receptor Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Gene Expression Tube Morphogenesis Positive Regulation Of MAPK Cascade Muscle Structure Development Regulation Of Cardiac Muscle Tissue Development Morphogenesis Of An Epithelium Cellular Response To Organic Substance Positive Regulation Of Striated Muscle Tissue Development Positive Regulation Of Muscle Tissue Development Regulation Of Cellular Protein Metabolic Process Cellular Response To Retinoic Acid Skeletal System Development Wound Healing Regulation Of MAPK Cascade Regulation Of Protein Metabolic Process Embryonic Morphogenesis Stem Cell Proliferation Tissue Morphogenesis Canonical Wnt Signaling Pathway Renal Tubule Development Response To Wounding Tube Development Regulation Of Catalytic Activity Kidney Morphogenesis
Tagcloud ?		adulthood af amniotic band characterizing cloned declines decreasing developmental dramatically glypican immunoblot mannose midgestation mpr ontogeny parallels phosphomannan predispose preterm prominent pronounced quantitatively rodent rodents saturable see undergo wilms