GPC3

Description		glypican 3
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GO Annotations	Cellular Component	Lysosome Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Membrane Lysosomal Lumen Side Of Membrane
	Molecular Function	Protein Binding Peptidase Inhibitor Activity Peptidyl-dipeptidase Inhibitor Activity
	Biological Process	Branching Involved In Ureteric Bud Morphogenesis Kidney Development Smoothened Signaling Pathway Negative Regulation Of Cell Population Proliferation Response To Bacterium Anatomical Structure Morphogenesis Animal Organ Morphogenesis Anterior/posterior Axis Specification Regulation Of Signal Transduction Body Morphogenesis Cell Migration Bone Mineralization Osteoclast Differentiation Lung Development Positive Regulation Of BMP Signaling Pathway Embryonic Hindlimb Morphogenesis Regulation Of Growth Cell Migration Involved In Gastrulation Positive Regulation Of Protein Catabolic Process Positive Regulation Of Endocytosis Negative Regulation Of Smoothened Signaling Pathway Positive Regulation Of Smoothened Signaling Pathway Negative Regulation Of Growth Positive Regulation Of D-glucose Import Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Canonical Wnt Signaling Pathway Coronary Vasculature Development Cell Proliferation Involved In Kidney Development Mesenchymal Cell Proliferation Involved In Ureteric Bud Development Mesonephric Duct Morphogenesis Cell Proliferation Involved In Metanephros Development Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Localization To Membrane Regulation Of Non-canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway
Pathways		Glycosaminoglycan-protein linkage region biosynthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Defective B3GALT6 causes EDSP2 and SEMDJL1 Post-translational protein phosphorylation Attachment and Entry Attachment and Entry Retinoid metabolism and transport Respiratory syncytial virus (RSV) attachment and entry RSV-host interactions
Drugs
Diseases		Heparan sulfate proteoglycan gene defects, including: Dyssegmental dysplasia, Silverman-Handmaker type; Schwartz-Jampel syndrome; Simpson-Golabi-Behmel syndrome, type 1; Omodysplasia 1; Multiple exostoses
GWAS		Educational attainment (years of education) ( 30038396) Relative hand skill ( 24068947)
Interacting Genes		6 interacting genes: APPL1 FGF2 IGF2 PTPRS WNT3A WNT7B
Entrez ID		2719
HPRD ID		02074
Ensembl ID		ENSG00000147257
Uniprot IDs		B4DTD8 I6QTG3 P51654 Q53H15
PDB IDs		7ZA1 7ZAW
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Fate Specification Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Embryonic Placenta Morphogenesis Regulation Of Developmental Growth Canonical Wnt Signaling Pathway Embryonic Morphogenesis Osteoblast Differentiation Positive Regulation Of Cell Fate Commitment Receptor Ligand Activity Regulation Of Growth Positive Regulation Of Developmental Growth Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Striated Muscle Tissue Development Positive Regulation Of Skeletal Muscle Tissue Development Regulation Of Collateral Sprouting Regulation Of Cell Fate Specification Regulation Of Signal Transduction Positive Regulation Of Epithelial Cell Proliferation Regulation Of Skeletal Muscle Tissue Development Regulation Of Cell Differentiation Cytokine Activity Negative Regulation Of Axon Extension Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Growth Chordate Embryonic Development In Utero Embryonic Development Synapse Organization Frizzled Binding Regulation Of Cell Communication Regulation Of Signaling Wnt Signaling Pathway Regulation Of Fibroblast Migration Regulation Of Striated Muscle Tissue Development Cell Development Positive Chemotaxis Regulation Of Muscle Organ Development Regulation Of Cell Fate Commitment Cell Surface Receptor Signaling Pathway Positive Regulation Of Organ Growth Non-canonical Wnt Signaling Pathway Negative Regulation Of Axonogenesis Positive Regulation Of Neural Precursor Cell Proliferation Neuron Differentiation Regulation Of Neurogenesis Regulation Of Epithelial Cell Proliferation Cellular Response To Retinoic Acid Signal Transduction Tissue Morphogenesis Hippocampus Development
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