GPC3 and FGF2

Number of citations of the paper that reports this interaction (PMID 12478660)
34

Data Source:
HPRD (in vitro, in vivo)

		GPC3	FGF2
Gene Name		glypican 3	fibroblast growth factor 2 (basic)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Proteinaceous Extracellular Matrix Extracellular Space Golgi Lumen Plasma Membrane Integral Component Of Plasma Membrane Lysosomal Lumen Anchored Component Of Plasma Membrane Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Nucleus
	Molecular Function	Protein Binding Heparan Sulfate Proteoglycan Binding Peptidyl-dipeptidase Inhibitor Activity	Fibroblast Growth Factor Receptor Binding Cytokine Activity Protein Binding Growth Factor Activity Heparin Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Chemoattractant Activity
	Biological Process	Retinoid Metabolic Process Branching Involved In Ureteric Bud Morphogenesis Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Phototransduction, Visible Light Pathogenesis Anatomical Structure Morphogenesis Anterior/posterior Axis Specification Body Morphogenesis Negative Regulation Of Peptidase Activity Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Bone Mineralization Osteoclast Differentiation Lung Development Positive Regulation Of BMP Signaling Pathway Embryonic Hindlimb Morphogenesis Small Molecule Metabolic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Endocytosis Negative Regulation Of Smoothened Signaling Pathway Positive Regulation Of Smoothened Signaling Pathway Negative Regulation Of Growth Positive Regulation Of Glucose Import Negative Regulation Of Epithelial Cell Proliferation Coronary Vasculature Development Mesenchymal Cell Proliferation Involved In Ureteric Bud Development Mesonephric Duct Morphogenesis Cell Proliferation Involved In Metanephros Development Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway	Activation Of MAPK Activity Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Endothelial Cell Proliferation Cell Migration Involved In Sprouting Angiogenesis Phosphatidylinositol Biosynthetic Process Chemotaxis Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Ras Protein Signal Transduction Nervous System Development Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Organ Morphogenesis Negative Regulation Of Fibroblast Migration Positive Regulation Of Phospholipase C Activity Growth Factor Dependent Regulation Of Skeletal Muscle Satellite Cell Proliferation Extracellular Matrix Organization Hyaluronan Catabolic Process Inositol Phosphate Biosynthetic Process Somatic Stem Cell Maintenance Fc-epsilon Receptor Signaling Pathway Wound Healing Positive Regulation Of Cell Fate Specification Positive Regulation Of MAP Kinase Activity Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Regulation Of Angiogenesis Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Embryonic Morphogenesis Positive Chemotaxis Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cell Division Positive Regulation Of Cardiac Muscle Cell Proliferation Negative Regulation Of Cell Death Chondroblast Differentiation Negative Regulation Of Wound Healing Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Sprouting Angiogenesis Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor
Pathways		MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type Heparan sulfate/heparin (HS-GAG) metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis MPS IIIC - Sanfilippo syndrome C Retinoid metabolism and transport Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS Diseases associated with visual transduction MPS IV - Morquio syndrome A Visual phototransduction MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome Metabolism of carbohydrates HS-GAG biosynthesis HS-GAG degradation MPS VI - Maroteaux-Lamy syndrome	Signaling by the B Cell Receptor (BCR) Phospholipase C-mediated cascade Signaling by FGFR in disease SHC-mediated cascade Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Signaling by FGFR2 mutants Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade Signaling by activated point mutants of FGFR1 Signaling by FGFR1 mutants PI3K Cascade Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions GAB1 signalosome Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer Activated point mutants of FGFR2 PI3K events in ERBB4 signaling Signaling by ERBB2 FGFR4 ligand binding and activation Syndecan interactions Signaling by EGFR Signaling by FGFR3 mutants Downstream signal transduction Signaling by activated point mutants of FGFR3 Fc epsilon receptor (FCERI) signaling Signaling by FGFR mutants Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade IRS-related events triggered by IGF1R Transcriptional regulation of pluripotent stem cells PI3K events in ERBB2 signaling FGFR1b ligand binding and activation Downstream signaling of activated FGFR FGFR3c ligand binding and activation FGFR1c ligand binding and activation FGFR2c ligand binding and activation FGFR ligand binding and activation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Non-integrin membrane-ECM interactions FGFR3 ligand binding and activation Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR FGFR2 ligand binding and activation FRS2-mediated cascade IRS-mediated signalling FGFR1 ligand binding and activation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PI3K Cascade
Drugs			Sucralfate Pentosan Polysulfate Sirolimus 1,4-Dideoxy-O2-Sulfo-Glucuronic Acid N,O6-Disulfo-Glucosamine 1,4-Dideoxy-5-Dehydro-O2-Sulfo-Glucuronic Acid
Diseases
GWAS
Protein-Protein Interactions		4 interactors: FGF2 IGF2 WNT3A WNT7B	29 interactors: API5 CASP1 CD44 CEP57 CRYAB CSNK2A1 CSNK2A2 CSNK2B CXCL13 FGFBP1 FGFR1 FGFR3 FGFR4 FGFRL1 GPC3 GPC4 HSPG2 NRP1 PF4 PRMT1 PTX3 RPL6 RPS19 RPS6KA3 SDC1 SDC2 SDC3 THBS1 VTN
Entrez ID		2719	2247
HPRD ID		02074	00622
Ensembl ID		ENSG00000147257	ENSG00000138685
Uniprot IDs		B4DTD8 I6QTG3 P51654 Q53H15	P09038
PDB IDs			1BAS 1BFB 1BFC 1BFF 1BFG 1BLA 1BLD 1CVS 1EV2 1FGA 1FQ9 1II4 1IIL 2BFH 2FGF 4FGF
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Cell Fate Specification Positive Regulation Of Transferase Activity Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Positive Regulation Of Cell Proliferation Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Positive Regulation Of Cell Fate Commitment Organ Morphogenesis Regulation Of Cell Fate Specification Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Muscle Cell Differentiation Regulation Of Cell Fate Commitment Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Epithelial Tube Morphogenesis Positive Regulation Of Receptor Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Gene Expression Tube Morphogenesis Positive Regulation Of MAPK Cascade Muscle Structure Development Regulation Of Cardiac Muscle Tissue Development Morphogenesis Of An Epithelium Cellular Response To Organic Substance Positive Regulation Of Striated Muscle Tissue Development Positive Regulation Of Muscle Tissue Development Regulation Of Cellular Protein Metabolic Process Cellular Response To Retinoic Acid Skeletal System Development Wound Healing Regulation Of MAPK Cascade Regulation Of Protein Metabolic Process Embryonic Morphogenesis Stem Cell Proliferation Tissue Morphogenesis Canonical Wnt Signaling Pathway Renal Tubule Development Response To Wounding Tube Development Regulation Of Catalytic Activity Kidney Morphogenesis	Response To External Stimulus Glycosaminoglycan Catabolic Process Anatomical Structure Morphogenesis Anatomical Structure Development Response To Stimulus Cellular Response To Stimulus Signal Transduction Chondroitin Sulfate Metabolic Process Regulation Of Proteolysis Negative Regulation Of Proteolysis Developmental Process Negative Regulation Of Protein Processing Signaling Phototransduction, Visible Light Retinoid Metabolic Process Cell Communication Locomotion Cellular Response To Growth Factor Stimulus Regulation Of Protein Processing Positive Regulation Of Signal Transduction Diterpenoid Metabolic Process Response To Growth Factor Detection Of Visible Light Regulation Of Cellular Component Organization Chemotaxis System Development Glycosaminoglycan Metabolic Process Multicellular Organismal Development Phototransduction Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Glycosaminoglycan Biosynthetic Process Regulation Of Cellular Process Proteoglycan Metabolic Process Detection Of Light Stimulus Response To Organic Substance Cell Differentiation Pathogenesis Movement Of Cell Or Subcellular Component Regulation Of Protein Metabolic Process Isoprenoid Metabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Hydrolase Activity Defense Response Regulation Of Peptidase Activity Protein Metabolic Process Negative Regulation Of Peptidase Activity Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Cysteine-type Endopeptidase Activity
Tagcloud ?		adulthood af amniotic band characterizing cloned declines decreasing developmental dramatically glypican immunoblot mannose midgestation mpr ontogeny parallels phosphomannan predispose preterm prominent pronounced quantitatively rodent rodents saturable see undergo wilms	accumulated altering bdnf believed ca2 causally cerebellar correlates dependency downregulating downregulation elicited evoked excitotoxic excitotoxicity fibroblast fura granule neurotrophic nmda nr1 nr2a nr2c prevent protect rnase trauma trophic vulnerable
Tagcloud (Difference) ?		adulthood af amniotic band characterizing cloned declines decreasing developmental dramatically glypican immunoblot mannose midgestation mpr ontogeny parallels phosphomannan predispose preterm prominent pronounced quantitatively rodent rodents saturable see undergo wilms	accumulated altering bdnf believed ca2 causally cerebellar correlates dependency downregulating downregulation elicited evoked excitotoxic excitotoxicity fibroblast fura granule neurotrophic nmda nr1 nr2a nr2c prevent protect rnase trauma trophic vulnerable
Tagcloud (Intersection) ?