DCC and PTK2

Number of citations of the paper that reports this interaction (PMID 15494733)
54

Data Source:
HPRD (in vivo, in vitro)

		DCC	PTK2
Gene Name		DCC netrin 1 receptor	protein tyrosine kinase 2
Image
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Integral Component Of Membrane Axon Growth Cone Membrane Membrane Raft	Stress Fiber Nucleus Cytoplasm Microtubule Organizing Center Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Apical Plasma Membrane Lamellipodium Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
	Molecular Function	Transcription Coactivator Activity Transmembrane Signaling Receptor Activity Netrin Receptor Activity Protein Binding Identical Protein Binding	Actin Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signal Transducer Activity Receptor Binding Protein Binding ATP Binding JUN Kinase Binding Protein Kinase Binding SH2 Domain Binding
	Biological Process	Neuron Migration Response To Amphetamine Apoptotic Process Axonogenesis Axon Guidance Positive Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development Spinal Cord Ventral Commissure Morphogenesis Dorsal/ventral Axon Guidance Anterior/posterior Axon Guidance Netrin-activated Signaling Pathway Positive Regulation Of Apoptotic Process Negative Regulation Of Collateral Sprouting Positive Regulation Of ERK1 And ERK2 Cascade Apoptotic Signaling Pathway Regulation Of Neuron Death Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Dendrite Development	Microtubule Cytoskeleton Organization Angiogenesis Vasculogenesis Neuron Migration Placenta Development Positive Regulation Of Protein Phosphorylation Heart Morphogenesis Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cytoskeleton Organization Signal Complex Assembly Epidermal Growth Factor Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Axon Guidance Blood Coagulation Positive Regulation Of Cell Proliferation Regulation Of Cell Shape Embryo Development Regulation Of Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Central Nervous System Neuron Axonogenesis Negative Regulation Of Cell-cell Adhesion Establishment Of Cell Polarity Platelet Activation Extracellular Matrix Organization Positive Regulation Of Cell Migration Regulation Of Rho GTPase Activity Regulation Of Cell Adhesion Mediated By Integrin Netrin-activated Signaling Pathway Peptidyl-tyrosine Autophosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Establishment Of Nucleus Localization Regulation Of Cell Proliferation Negative Regulation Of Apoptotic Process Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Regulation Of Osteoblast Differentiation Positive Regulation Of Protein Kinase Activity Negative Regulation Of Organ Growth Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Cell Motility Negative Regulation Of Axonogenesis Regulation Of Cytoskeleton Organization Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Synapse Assembly Growth Hormone Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Anoikis
Pathways		DSCAM interactions Axon guidance Role of second messengers in netrin-1 signaling DCC mediated attractive signaling Programmed Cell Death Netrin mediated repulsion signals Netrin-1 signaling Role of DCC in regulating apoptosis Extrinsic Pathway	Axon guidance DCC mediated attractive signaling Netrin mediated repulsion signals Platelet Aggregation (Plug Formation) VEGFA-VEGFR2 Pathway EPHB-mediated forward signaling EPHA-mediated growth cone collapse Programmed Cell Death EPH-Ephrin signaling NCAM signaling for neurite out-growth Netrin-1 signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System Apoptotic cleavage of cellular proteins Apoptotic execution phase p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling Signal regulatory protein (SIRP) family interactions GRB2:SOS provides linkage to MAPK signaling for Integrins Signaling by VEGF Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS		Alcoholism (alcohol use disorder factor score) ( 21529783) Body mass index (interaction) ( 23192594) Gallbladder cancer ( 22318345) Obesity-related traits ( 23251661)	Response to interferon beta therapy ( 21502966)
Protein-Protein Interactions		16 interactors: ADORA2B APPL1 AR BARD1 CASP3 CASP9 MAPK3 MAZ NCK1 NTN1 PITPNA PTK2 PTK2B RPL5 SIAH1 SIAH2	104 interactors: ACTN1 APP ARHGAP26 ASAP1 ATG12 BBS10 BCAR1 BIN1 BMX CCR5 CD47 CD79B CIB1 CRK CSK CSPG4 CXCR4 DCC DDX39A DEF6 DLGAP3 DNM2 EEF1G EFS EGFR EPHA2 EPHB2 EPS8L2 ERBB2 ERBB3 EZR F13A1 FBP1 FGR FLT1 FLT4 FYN GIT1 GRB2 GRB7 GSK3B GZMB HES1 IGHM INSR IRS1 ITGAV ITGB1 ITGB2 ITGB3 ITGB4 ITGB5 JAK2 KCNMA1 LCK LPXN LYN MAPK8IP3 MDM2 MICAL1 NACAD NASP NCK1 NCK2 NEDD8 NEDD9 NEO1 PDGFRB PIAS1 PIK3R1 PKD1 PLCG1 PPP1CB PTK2B PTPN11 PTPN12 PTPRH PXN RAC1 RB1CC1 RET RIPK1 ROCK1 SAE1 SELE SHC1 SOCS2 SOCS3 SORBS1 SRC SRPK1 STAT1 SYK TGFB1I1 TLN1 TNFRSF1A TNS1 TP53 TRIO TRIP6 TSC2 VCL YES1 ZNF331
Entrez ID		1630	5747
HPRD ID		00391	02859
Ensembl ID			ENSG00000169398
Uniprot IDs		P43146 Q49AK4	E7ESA6 Q05397 Q59GM6 Q658W2
PDB IDs		2ED7 2ED8 2ED9 2EDB 2EDD 2EDE 3AU4	1K04 1K05 1MP8 1OW6 1OW7 1OW8 2ETM 2IJM 2RA7 3B71 3BZ3 3PXK 3S9O 4EBV 4EBW 4GU6 4GU9 4I4E 4I4F 4K8A 4K9Y 4KAB 4KAO
Enriched GO Terms of Interacting Partners?		Cell Morphogenesis Involved In Differentiation Apoptotic Process Axon Guidance Programmed Cell Death Regulation Of Apoptotic Process Cell Death Death Cell Morphogenesis Regulation Of Cell Death Neuron Differentiation Signal Complex Assembly Neuron Projection Development Axonogenesis Cell Development Response To External Stimulus Axon Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Development Chemotaxis Neuron Projection Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Generation Of Neurons Cell Projection Organization Neurogenesis Positive Regulation Of Protein Metabolic Process Locomotion Vascular Endothelial Growth Factor Receptor Signaling Pathway Anatomical Structure Morphogenesis Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Peptidyl-tyrosine Autophosphorylation Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Positive Regulation Of Cell Death Regulation Of Protein Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process ERBB Signaling Pathway Nervous System Development Regulation Of Protein Kinase Activity Glial Cell Apoptotic Process Regulation Of Kinase Activity System Development Positive Regulation Of Intracellular Signal Transduction Regulation Of Immune System Process	Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Locomotion Cell Communication Cell Surface Receptor Signaling Pathway Signal Transduction Signaling Immune System Process Regulation Of Signal Transduction Movement Of Cell Or Subcellular Component Response To Stimulus Regulation Of Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Protein Phosphorylation Response To External Stimulus Regulation Of Phosphorus Metabolic Process Cell Migration Cellular Response To Stimulus Cell Motility Chemotaxis Blood Coagulation Hemostasis Innate Immune Response Response To Growth Factor Response To Wounding Wound Healing Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Regulation Of Kinase Activity Positive Regulation Of Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Cell Adhesion Cellular Response To Growth Factor Stimulus ERBB Signaling Pathway Anatomical Structure Morphogenesis Leukocyte Migration Defense Response Regulation Of Body Fluid Levels Positive Regulation Of Protein Phosphorylation Response To Stress Axon Guidance Immune Response Cellular Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Response To Organic Substance Regulation Of Protein Kinase Activity Axon Development
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