RHEBL1 and BMPR1B

Number of citations of the paper that reports this interaction (PMID 15761153)
154

Data Source:
HPRD (in vivo)

		RHEBL1	BMPR1B
Gene Name		Ras homolog enriched in brain like 1	bone morphogenetic protein receptor, type IB
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Endomembrane System Membrane	Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex
	Molecular Function	GTP Binding Metal Ion Binding	Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Activity, Type I Protein Binding ATP Binding SMAD Binding Metal Ion Binding
	Biological Process	Small GTPase Mediated Signal Transduction TOR Signaling Positive Regulation Of NF-kappaB Transcription Factor Activity	Skeletal System Development Cartilage Condensation Ovarian Cumulus Expansion Eye Development Chondrocyte Development Protein Phosphorylation Inflammatory Response Dorsal/ventral Pattern Formation Signal Transduction By Phosphorylation Proteoglycan Biosynthetic Process Positive Regulation Of Bone Mineralization BMP Signaling Pathway Retinal Ganglion Cell Axon Guidance Limb Morphogenesis Ovulation Cycle Positive Regulation Of Cell Differentiation Positive Regulation Of Osteoblast Differentiation Retina Development In Camera-type Eye Endochondral Bone Morphogenesis Positive Regulation Of Cartilage Development Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Chondrocyte Proliferation
Pathways			Signaling by BMP
Drugs
Diseases
GWAS			Attention deficit hyperactivity disorder ( 20732626)
Protein-Protein Interactions		13 interactors: ACVR1 AKT1 APPL1 BMPR1B EIF4EBP1 FHL3 MTOR PRKAB2 SMAD1 SMAD2 SMAD4 TGFBR1 TXNL4A	63 interactors: AMHR2 APP ARHGEF6 BAMBI BMP15 BMP2 BMP4 BMP6 BMP7 BMPR1A BMPR2 CDK14 CDK4 CHN1 DCAF12 DCAF6 DCAF7 FANCL GDF5 GDF6 GDF9 KLHL1 LZTR1 NKIRAS1 OXSR1 PAK1 PLEKHB1 POMK PPP2CA PPP3CC RAB25 RAB38 RAB6B RAN RAP2A RASD2 RASL12 RHEBL1 RHOD RHOJ RPS27A RRAS2 SASH3 SH3KBP1 SMAD6 SMAD7 SNX6 SOCS6 SQSTM1 SRGAP1 STAMBP STK35 STUB1 TGFBR1 TNNT1 TRAF6 TTC17 TTC27 UBA52 UBE2Z UBXN1 USP45 VEPH1
Entrez ID		121268	658
HPRD ID		15245	04457
Ensembl ID		ENSG00000167550	ENSG00000138696
Uniprot IDs		Q8TAI7	A8KAE3 O00238
PDB IDs		3OES	3MDY
Enriched GO Terms of Interacting Partners?		Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Response To Organic Substance Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Insulin Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta SMAD Protein Complex Assembly Response To Organic Substance Intracellular Signal Transduction Cellular Response To Insulin Stimulus BMP Signaling Pathway Protein Phosphorylation Pattern Specification Process Positive Regulation Of Cell Differentiation Cell Fate Commitment Cellular Response To Hormone Stimulus Response To Insulin Regulation Of Cell Differentiation Activin Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Gamete Generation Cellular Response To Peptide Mesoderm Development Urogenital System Development Phosphorylation Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Cellular Component Organization Sexual Reproduction Peptidyl-threonine Phosphorylation Positive Regulation Of Transcription, DNA-templated Multicellular Organismal Reproductive Process Gastrulation Response To Organonitrogen Compound Regulation Of Epithelial To Mesenchymal Transition Cell Cycle Multicellular Organism Reproduction Regulation Of Pathway-restricted SMAD Protein Phosphorylation Response To Peptide Hormone Posttranscriptional Regulation Of Gene Expression Signal Transduction Cardiovascular System Development Mesenchyme Development Regulation Of Extrinsic Apoptotic Signaling Pathway Cellular Response To Organonitrogen Compound Organ Development	Regulation Of Pathway-restricted SMAD Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation BMP Signaling Pathway Intracellular Signal Transduction Regulation Of Signal Transduction Signal Transduction Signaling Regulation Of Protein Phosphorylation Regulation Of Signaling Cell Communication Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Positive Regulation Of Protein Modification Process Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Cellular Response To Growth Factor Stimulus Regulation Of Phosphorus Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Metabolic Process Response To Growth Factor Positive Regulation Of Protein Phosphorylation Cellular Response To Transforming Growth Factor Beta Stimulus SMAD Protein Signal Transduction Response To Transforming Growth Factor Beta Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Stimulus Small GTPase Mediated Signal Transduction Regulation Of MAPK Cascade Cellular Protein Modification Process Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Cell Surface Receptor Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Signal Transduction By Phosphorylation Regulation Of Cell Development Regulation Of Cellular Process Regulation Of Cell Death Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Phosphorylation
Tagcloud ?		aspartate binds cad carbamoyl consist de dihydroorotase effector farnesyltransferase gtp gtpases immunostaining knocking lysosomes mislocalized multifunctional novo nucleotides phosphate pronounced pyrimidine rheb2 superfamily synthetase transcarbamoylase tsc2 utp	125b acvr1b acvr2a arid3b bak1 bcl2l2 bear bim cadm1 cardio cardiology cmass e2f3 fgfr2 fgfr3 glut3 il6r jph2 men1 mirs onco orchestration raf1 sitr7 smoothened st7l twist1 wee1 wnt7a
Tagcloud (Difference) ?		aspartate binds cad carbamoyl consist de dihydroorotase effector farnesyltransferase gtp gtpases immunostaining knocking lysosomes mislocalized multifunctional novo nucleotides phosphate pronounced pyrimidine rheb2 superfamily synthetase transcarbamoylase tsc2 utp	125b acvr1b acvr2a arid3b bak1 bcl2l2 bear bim cadm1 cardio cardiology cmass e2f3 fgfr2 fgfr3 glut3 il6r jph2 men1 mirs onco orchestration raf1 sitr7 smoothened st7l twist1 wee1 wnt7a
Tagcloud (Intersection) ?