RHEBL1 and APPL1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		RHEBL1	APPL1
Description		RHEB like 1	adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Endomembrane System Membrane	Ruffle Nucleus Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Endosome Membrane Vesicle Membrane Actin Cytoskeleton Membrane Cytoplasmic Vesicle Early Endosome Membrane Early Phagosome Cell Projection Macropinosome Phagocytic Vesicle Extracellular Exosome Intracellular Vesicle Glutamatergic Synapse
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Metal Ion Binding	Phosphatidylserine Binding Protein Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Protein Kinase B Binding Protein-containing Complex Binding Beta-tubulin Binding
	Biological Process	Signal Transduction Small GTPase-mediated Signal Transduction TOR Signaling Positive Regulation Of NF-kappaB Transcription Factor Activity	Protein Import Into Nucleus Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Insulin Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Regulation Of Fibroblast Migration Signaling Adiponectin-activated Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Innate Immune Response Regulation Of D-glucose Import Positive Regulation Of D-glucose Import Positive Regulation Of Melanin Biosynthetic Process Positive Regulation Of Transport Maintenance Of Synapse Structure Positive Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Macropinocytosis Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways			Caspase activation via Dependence Receptors in the absence of ligand
Drugs
Diseases
GWAS		Bipolar disorder ( 28115744 31043756 33263727) Reaction time ( 29844566)
Interacting Genes		13 interacting genes: ACVR1 AKT1 APPL1 BMPR1B EIF4EBP1 FHL3 MTOR PRKAB2 SMAD1 SMAD2 SMAD4 TGFBR1 TXNL4A	72 interacting genes: ADI1 ADIPOR1 ADIPOR2 AGL AKT1 AKT2 ANKRD1 APPL2 ATP2A1 BATF3 BIN1 BRWD1 C1QTNF9 CBL CBLB CIPC CMTM4 CTTNBP2 DACT1 DCC DNM2 DOK2 DOK3 DOK7 DPYSL5 DTNA DYSF EGFR FARS2 FSHR GABARAP GABARAPL1 GABARAPL2 GPC3 HDAC2 HSPB1 ID1 INO80E KLF15 KXD1 LUC7L MAGEA9 MAGEC3 MAP1LC3A MAP1LC3B MAP1LC3C MAP3K1 MEOX1 MTA2 MYCBP2 MYH3 PIK3CA PIK3R1 PIK3R2 PLEKHF2 PNMA5 RAB21 RAB5A RBBP7 RHEBL1 RSPH1 RUVBL2 SCAPER SH2D2A SOCS6 SPART TP53 TP53BP2 TRAF2 UBC UBE2O ZNF829
Entrez ID		121268	26060
HPRD ID		15245	05053
Ensembl ID		ENSG00000167550	ENSG00000157500
Uniprot IDs		Q8TAI7	Q9UKG1
PDB IDs		3OES	2EJ8 2ELA 2ELB 2Q12 2Q13 2Z0N 2Z0O 5C5B
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Response To Growth Factor Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway SMAD Binding I-SMAD Binding Cellular Response To Growth Factor Stimulus Positive Regulation Of Epithelial To Mesenchymal Transition Cell Fate Commitment Transforming Growth Factor Beta Receptor Activity, Type I Activin Receptor Signaling Pathway SMAD Protein Complex Regulation Of Epithelial To Mesenchymal Transition Heteromeric SMAD Protein Complex Osteoblast Differentiation Ameboidal-type Cell Migration Positive Regulation Of Multicellular Organismal Process Transmembrane Receptor Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Differentiation Pattern Specification Process BMP Signaling Pathway Homomeric SMAD Protein Complex SMAD Protein Signal Transduction Positive Regulation Of Gene Expression Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regionalization Cellular Response To BMP Stimulus Activin Responsive Factor Complex Positive Regulation Of Developmental Process Animal Organ Development Ventricular Septum Morphogenesis Cell Surface Receptor Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Translational Initiation Gastrulation Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cell Differentiation Regulation Of Multicellular Organismal Process Protein Serine/threonine Kinase Activity Heart Valve Morphogenesis Tissue Development Mesoderm Development Activin Receptor Complex Activin Receptor Activity, Type I Trophoblast Cell Migration Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Embryonic Pattern Specification BMP Receptor Activity	Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Mitophagy Autophagy Of Mitochondrion Phospholipid Binding Ubiquitin Protein Ligase Binding Autophagosome Maturation Cytosol Regulation Of Cellular Component Organization Autophagosome Membrane Signal Transduction Regulation Of D-glucose Import Endomembrane System Cell Surface Receptor Signaling Pathway Positive Regulation Of D-glucose Import Response To Starvation Macroautophagy Protein Binding Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Protein Localization To Membrane Regulation Of D-glucose Transmembrane Transport Positive Regulation Of D-glucose Transmembrane Transport Cellular Response To Starvation Autophagosome Regulation Of Growth Negative Regulation Of Multicellular Organismal Process Glucose Homeostasis Carbohydrate Homeostasis Intracellular Signaling Cassette Protein-containing Complex Disassembly Intracellular Signal Transduction Autophagosome Assembly Adiponectin-activated Signaling Pathway Cytoplasm Autophagy Autophagosome Organization Cellular Response To Stress Phosphatidylinositol 3-kinase Regulatory Subunit Binding Phosphatidylinositol 3-kinase Complex, Class IA Regulation Of Cellular Localization Rhythmic Process Cellular Response To Nutrient Levels Establishment Of Protein Localization Histone Deacetylase Binding Insulin Receptor Signaling Pathway Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Protein Localization To Membrane Response To Nutrient Levels Regulation Of Developmental Process
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