HINFP and U2AF1

Number of citations of the paper that reports this interaction (PubMedID 17577209)
0

Data Source:
BioGRID (two hybrid)

		HINFP	U2AF1
Description		histone H4 transcription factor	U2 small nuclear RNA auxiliary factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cajal Body	Nucleus Nucleoplasm Spliceosomal Complex Cajal Body Nuclear Speck Catalytic Step 2 Spliceosome U2AF Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Enzyme Binding Histone Binding Metal Ion Binding	Nucleic Acid Binding RNA Binding Protein Binding Zinc Ion Binding Pre-mRNA 3'-splice Site Binding Metal Ion Binding RS Domain Binding
	Biological Process	DNA Damage Checkpoint Signaling G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development DNA Repair DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cell Cycle G1/S Phase Transition Establishment Of Protein Localization Myoblast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing
Pathways			Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS			Blood and toenail selenium levels ( 25343990)
Interacting Genes		30 interacting genes: ATN1 CDYL2 EFTUD2 ELP4 GSPT1 IHO1 JUND MBD2 MDC1 MIF4GD MKI67 MORF4L1 NDUFAB1 NIPBL NPDC1 POM121C PRRC2C RBM17 RBM26 RPUSD4 TLE3 TP53 TRA2B TRAF2 TRIM39 TRIM44 TTF2 U2AF1 UFL1 ZNHIT1	58 interacting genes: ALG13 AP1B1 AP2B1 CARNMT1 CHERP CIRSR CLK2 CPEB2 DHX38 EFHC2 EPB41 FILNC1 FRA10AC1 HINFP HMGB2 HNRNPK HNRNPM IL7R JMJD6 KRT1 KRT75 MAP1B MEOX2 MFAP1 MLH1 NDN NKAP NXF1 PABPC1 PRPF19 PRPF38A PRPF4 PRPF40A PTEN RBM10 RNPS1 RP9 SF3A3 SF3B2 SNRNP35 SNRPD1 SRPK1 SRPK2 SRRM4 SRSF1 SRSF2 SRSF3 SUV39H1 TOE1 TRA2B U2AF2 VEGFA VPS26C WEE2-AS1 ZCCHC10 ZNF417 ZRANB2 ZRSR2
Entrez ID		25988	7307
HPRD ID		07387	01871
Ensembl ID		ENSG00000172273	ENSG00000160201
Uniprot IDs		Q9BQA5	Q01081 Q7Z780
PDB IDs			1JMT
Enriched GO Terms of Interacting Partners?		Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleoplasm MRNA Metabolic Process Nucleus Spliceosomal Complex DNA Damage Checkpoint Signaling RNA Splicing Regulation Of Cell Cycle Regulation Of Primary Metabolic Process RNA Metabolic Process MRNA Processing Negative Regulation Of Cell Cycle Process Signal Transduction In Response To DNA Damage Negative Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression RNA Binding Regulation Of Cell Cycle Process DNA Metabolic Process DNA Repair Mitotic DNA Damage Checkpoint Signaling Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Protein-containing Complex Mitotic DNA Integrity Checkpoint Signaling Positive Regulation Of Macromolecule Metabolic Process DNA Damage Response Negative Regulation Of Cell Cycle Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Metabolic Process Transcription Corepressor Activity RNA Splicing, Via Transesterification Reactions Chromatin Organization Regulation Of Nucleobase-containing Compound Metabolic Process RNA Processing Programmed Necrotic Cell Death Double-strand Break Repair Hematopoietic Stem Cell Differentiation Transcription Elongation Factor Complex Hematopoietic Progenitor Cell Differentiation Site Of Double-strand Break Negative Regulation Of Cell Cycle Phase Transition Protein Binding Positive Regulation Of Macromolecule Biosynthetic Process Protein Stabilization DNA Recombination Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process	RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Spliceosomal Complex Regulation Of MRNA Splicing, Via Spliceosome RNA Binding Nucleic Acid Metabolic Process Regulation Of MRNA Processing Regulation Of RNA Splicing Nuclear Speck Nucleic Acid Binding Nucleobase-containing Compound Metabolic Process Spliceosomal Complex Assembly Regulation Of MRNA Metabolic Process Catalytic Step 2 Spliceosome Nucleus Nucleoplasm Protein-RNA Complex Assembly Macromolecule Metabolic Process MRNA Binding U2-type Precatalytic Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Metabolic Process U12-type Spliceosomal Complex Negative Regulation Of RNA Splicing U2-type Spliceosomal Complex Positive Regulation Of RNA Splicing Precatalytic Spliceosome U1 SnRNP Negative Regulation Of Nucleobase-containing Compound Metabolic Process Ribonucleoprotein Complex Negative Regulation Of RNA Metabolic Process Protein-containing Complex Assembly U2-type Prespliceosome Assembly Regulation Of Nucleobase-containing Compound Metabolic Process U2 SnRNP Commitment Complex Positive Regulation Of Viral Genome Replication Pre-mRNA 3'-splice Site Binding U2AF Complex MRNA Splice Site Recognition Regulation Of RNA Metabolic Process Protein-containing Complex Organization MRNA 5'-splice Site Recognition T Cell Differentiation In Thymus
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