CAMK1 and CAMKK1

Number of citations of the paper that reports this interaction (PMID 10187789)
11

Data Source:
HPRD (in vivo)

		CAMK1	CAMKK1
Gene Name		calcium/calmodulin-dependent protein kinase I	calcium/calmodulin-dependent protein kinase kinase 1, alpha
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Cytosol
	Molecular Function	Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding	Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding
	Biological Process	Protein Phosphorylation Nucleocytoplasmic Transport Cell Cycle Signal Transduction Positive Regulation Of Neuron Projection Development Regulation Of Protein Localization Regulation Of Protein Binding Positive Regulation Of Protein Export From Nucleus Regulation Of Muscle Cell Differentiation Positive Regulation Of Muscle Cell Differentiation Positive Regulation Of Synapse Structural Plasticity Positive Regulation Of Dendritic Spine Development Positive Regulation Of Protein Serine/threonine Kinase Activity	Protein Phosphorylation Synaptic Transmission
Pathways			CREB phosphorylation through the activation of CaMKK Activation of NMDA receptor upon glutamate binding and postsynaptic events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Transmission across Chemical Synapses Post NMDA receptor activation events
Drugs
Diseases
GWAS			Smoking behavior ( 19247474)
Protein-Protein Interactions		15 interactors: APP ATF1 CALM1 CAMKK1 CAMKK2 CCND1 CDK4 CDKN1B EIF4G3 GAPDH GCM1 HDAC5 MARK2 NOS1 SYN1	8 interactors: AKT1 APP CALM1 CAMK1 CAMK1D CAMK4 SGK1 YWHAG
Entrez ID		8536	84254
HPRD ID		05412	13000
Ensembl ID		ENSG00000134072	ENSG00000004660
Uniprot IDs		B0YIY3 Q14012	F8W9H1 J3KPJ3 Q8N5S9
PDB IDs		4FG7 4FG8 4FG9 4FGB
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Positive Regulation Of Metabolic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Translation Signaling Cell Communication Regulation Of Phosphorus Metabolic Process Response To Metal Ion Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Peptidyl-cysteine S-nitrosylation Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Protein Metabolic Process Response To Organic Substance Phosphorylation Positive Regulation Of Mitotic Cell Cycle Phase Transition Cellular Response To Organic Substance Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Cell Cycle Phase Transition Regulation Of Phosphorylation Response To Inorganic Substance Regulation Of Cell Cycle Process Regulation Of Mitotic Cell Cycle Phase Transition Response To Organic Cyclic Compound Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Response To Drug Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of Gene Expression Positive Regulation Of Gene Expression Positive Regulation Of Cell Cycle Response To Abiotic Stimulus Regulation Of Cell Cycle Arrest Signal Transduction Regulation Of Catalytic Activity Cellular Protein Modification Process Cellular Response To Stimulus Cellular Protein Metabolic Process Positive Regulation Of Mitotic Cell Cycle Protein Metabolic Process Response To Stress Notch Signaling Pathway Protein Phosphorylation	Positive Regulation Of Transport Regulation Of Intracellular Transport Phosphorylation Regulation Of Neuron Differentiation Positive Regulation Of Intracellular Transport Protein Phosphorylation Regulation Of Catalytic Activity Regulation Of Neurogenesis Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Regulation Of Cell Differentiation Phosphate-containing Compound Metabolic Process Regulation Of Cell Development Regulation Of Cellular Localization Positive Regulation Of Protein Export From Nucleus Establishment Of Localization In Cell Regulation Of Protein Phosphorylation Positive Regulation Of Nitric-oxide Synthase Activity Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Nervous System Development Positive Regulation Of Monooxygenase Activity Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Phosphorylation Cellular Localization Cellular Response To Fibroblast Growth Factor Stimulus Defense Response Platelet Activation Response To Fibroblast Growth Factor System Development Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Nitric Oxide Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Establishment Of Protein Localization Cell Activation Reactive Nitrogen Species Metabolic Process Regulation Of Protein Export From Nucleus Neurotrophin Signaling Pathway Regulation Of Phosphorus Metabolic Process Intracellular Transport Positive Regulation Of Catalytic Activity Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Generation Of Neurons Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Oxidoreductase Activity Nucleocytoplasmic Transport Learning Or Memory Nuclear Transport Regulation Of Protein Localization
Tagcloud ?			akt apoptosis br calcium calmodulin er estrogen exact irrespective knockdown largely mb mcf mda moderately neural oncotarget pcp4 pep19 phospho potentially regulates serve sk slightly still thr308 unknown
Tagcloud (Difference) ?			akt apoptosis br calcium calmodulin er estrogen exact irrespective knockdown largely mb mcf mda moderately neural oncotarget pcp4 pep19 phospho potentially regulates serve sk slightly still thr308 unknown
Tagcloud (Intersection) ?