CAMK1 and CAMKK1

Number of citations of the paper that reports this interaction (PubMedID 9705275)
0

Data Source:
HPRD (in vivo)

		CAMK1	CAMKK1
Description		calcium/calmodulin dependent protein kinase I	calcium/calmodulin dependent protein kinase kinase 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Postsynaptic Density	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Catalytic Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Protein Phosphorylation Nucleocytoplasmic Transport Signal Transduction Nervous System Development Regulation Of Neuron Projection Development Positive Regulation Of Neuron Projection Development Cell Differentiation Negative Regulation Of Protein Binding Regulation Of Protein Localization Intracellular Signal Transduction Regulation Of Protein Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Export From Nucleus Regulation Of Synapse Organization Regulation Of Muscle Cell Differentiation Positive Regulation Of Muscle Cell Differentiation Positive Regulation Of Synapse Structural Plasticity Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Positive Regulation Of Dendritic Spine Development Positive Regulation Of Protein Serine/threonine Kinase Activity	Intracellular Signal Transduction
Pathways		Negative regulation of NMDA receptor-mediated neuronal transmission Activation of RAC1 downstream of NMDARs Activation of RAC1 downstream of NMDARs	CaMK IV-mediated phosphorylation of CREB CaMK IV-mediated phosphorylation of CREB CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Activation of RAC1 downstream of NMDARs Activation of RAC1 downstream of NMDARs
Drugs		Fostamatinib	Fostamatinib
Diseases
GWAS			Serum alkaline phosphatase levels ( 33339817) Smoking behavior ( 19247474)
Interacting Genes		23 interacting genes: APP ATF1 ATXN1 CALM1 CAMKK1 CAMKK2 CCND1 CDK4 CDKN1B EIF4G3 FBXO7 GAPDH GCM1 HDAC5 HSPB1 HUNK IL16 MARK2 NOS1 PIK3R3 PPME1 PPP2CA SYN1	10 interacting genes: AKT1 APP CALM1 CAMK1 CAMK1D CAMK4 CFTR PRKAA1 SGK1 YWHAG
Entrez ID		8536	84254
HPRD ID		05412	13000
Ensembl ID		ENSG00000134072	ENSG00000004660
Uniprot IDs		B0YIY3 Q14012	J3KPJ3 Q8N5S9
PDB IDs		4FG7 4FG8 4FG9 4FGB	6CCF 6CD6
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Mitotic Cell Cycle Phase Transition Protein Kinase Binding Cyclin D1-CDK4 Complex Cell Cycle Phase Transition Response To Metal Ion Peptidyl-cysteine S-nitrosylase Activity Signal Transduction Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Cytosol Regulation Of Mitotic Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Protein Kinase Activity Positive Regulation Of Biosynthetic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Calcium-mediated Signaling Regulation Of Mitotic Cell Cycle Phase Transition Protein Serine Kinase Activity Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Cell Differentiation Regulation Of Developmental Process Regulation Of Autophagy Positive Regulation Of Interleukin-1 Production Kinase Activity Regulation Of Metabolic Process Calcium-dependent Protein Binding Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of Calcium Ion Transport Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle Phase Transition Response To Lead Ion Calyx Of Held Regulation Of Neurotransmitter Uptake Regulation Of Cell Cycle Process Regulation Of Neuron Apoptotic Process Regulation Of Locomotion Nucleus Regulation Of Cell Cycle Calcium/calmodulin-dependent Protein Kinase Activity Protein-containing Complex Regulation Of Interleukin-1 Production Nucleoplasm Positive Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Mitotic Cell Cycle	Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase Activity Regulation Of Transport Calcium/calmodulin-dependent Protein Kinase Activity Protein K6-linked Ubiquitination Kinase Activity Intracellular Signal Transduction ATP Binding Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Positive Regulation Of Transport Positive Regulation Of Protein Localization Cellular Response To Oxygen-containing Compound Calmodulin Binding Regulation Of Protein Localization Cellular Response To Amino Acid Starvation Regulation Of Developmental Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Ketone Negative Regulation Of TORC1 Signaling Response To Amino Acid Starvation Positive Regulation Of TORC1 Signaling TORC1 Signaling Chloride Channel Regulator Activity Regulation Of Vesicle-mediated Transport Positive Regulation Of Immune System Process Regulation Of Phosphorus Metabolic Process Nucleotide Binding Response To Alcohol Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell TOR Signaling Positive Regulation Of TOR Signaling Regulation Of Cell Activation Negative Regulation Of TOR Signaling Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Positive Regulation Of Phosphate Metabolic Process Regulation Of TORC1 Signaling Positive Regulation Of Establishment Of Protein Localization Regulation Of Multicellular Organismal Process Response To Metal Ion Regulation Of Translational Initiation Signal Transduction Negative Regulation Of Immune Response To Tumor Cell Cellular Response To Hormone Stimulus Protein Phosphorylation Protein-containing Complex Regulation Of T Cell Mediated Immune Response To Tumor Cell Response To Stress Memory
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