CAMK1 and EIF4G3

Number of citations: 0 (PubMedID 14507913)
Data Source: HPRD (in vitro, in vivo)

		CAMK1	EIF4G3
Name		calcium/calmodulin dependent protein kinase I	eukaryotic translation initiation factor 4 gamma 3
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Postsynaptic Density	Cytosol Eukaryotic Translation Initiation Factor 4F Complex
	Molecular Function	Nucleotide Binding Catalytic Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	RNA Cap Binding RNA Binding MRNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding
	Biological Process	Protein Phosphorylation Nucleocytoplasmic Transport Signal Transduction Nervous System Development Regulation Of Neuron Projection Development Positive Regulation Of Neuron Projection Development Cell Differentiation Negative Regulation Of Protein Binding Regulation Of Protein Localization Intracellular Signal Transduction Regulation Of Protein Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Export From Nucleus Regulation Of Synapse Organization Regulation Of Muscle Cell Differentiation Positive Regulation Of Muscle Cell Differentiation Positive Regulation Of Synapse Structural Plasticity Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Positive Regulation Of Dendritic Spine Development Positive Regulation Of Protein Serine/threonine Kinase Activity	Translation Translational Initiation Regulation Of Translation Regulation Of Translational Initiation Spermatid Development Negative Regulation Of Autophagy Positive Regulation Of Translation
Pathways		Negative regulation of NMDA receptor-mediated neuronal transmission Activation of RAC1 downstream of NMDARs Activation of RAC1 downstream of NMDARs	ISG15 antiviral mechanism
Drugs		Fostamatinib	None
GWAS		No GWAS studies recorded	Basophil count ( 32888494 ) Basophil percentage of white cells ( 32888494 ) Chronotype ( 30696823 ) Cognitive decline rate in late mild cognitive impairment ( 26252872 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) General risk tolerance (MTAG) ( 30643258 ) Mean spheric corpuscular volume ( 32888494 ) Morning person ( 30696823 ) Postoperative acute renal failure after cardiac surgery ( 30678657 ) Red blood cell count ( 32888494 ) Social science traits (pleiotropy) (HIPO component 1) ( 30289880 ) Superior frontal gyrus grey matter volume ( 25335168 )
Interacting Genes		23 interacting genes: APP ATF1 ATXN1 CALM1 CAMKK1 CAMKK2 CCND1 CDK4 CDKN1B EIF4G3 FBXO7 GAPDH GCM1 HDAC5 HSPB1 HUNK IL16 MARK2 NOS1 PIK3R3 PPME1 PPP2CA SYN1	17 interacting genes: CAMK1 CTNND1 DDX19B EIF4A1 EIF4E HSPB1 LIG4 LSM3 MKNK1 PABPC1 PCNT PSMB6 RNF10 TRIM25 VAV2 VPS25 WDR37
Entrez ID		8536	8672
HPRD ID		05412	06802
Ensembl ID		ENSG00000134072	ENSG00000075151
Uniprot IDs		B0YIY3 Q14012	A0A0A0MSA7 A0A804HJV5 A0A8I5QJH9 A0A8J9G7U8 B4DXR2 O43432 Q59GJ0
PDB IDs		4FG7 4FG8 4FG9 4FGB	1HU3
GO Terms Enriched among Interactors		Intracellular Signal Transduction Mitotic Cell Cycle Phase Transition Protein Kinase Binding Cyclin D1-CDK4 Complex Cell Cycle Phase Transition Response To Metal Ion Peptidyl-cysteine S-nitrosylase Activity Signal Transduction Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Cytosol Regulation Of Mitotic Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Protein Kinase Activity Positive Regulation Of Biosynthetic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Calcium-mediated Signaling Regulation Of Mitotic Cell Cycle Phase Transition Protein Serine Kinase Activity Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Cell Differentiation Regulation Of Developmental Process Regulation Of Autophagy Positive Regulation Of Interleukin-1 Production Kinase Activity Regulation Of Metabolic Process Calcium-dependent Protein Binding Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of Calcium Ion Transport Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle Phase Transition Response To Lead Ion Calyx Of Held Regulation Of Neurotransmitter Uptake Regulation Of Cell Cycle Process Regulation Of Neuron Apoptotic Process Regulation Of Locomotion Nucleus Regulation Of Cell Cycle Calcium/calmodulin-dependent Protein Kinase Activity Protein-containing Complex Regulation Of Interleukin-1 Production Nucleoplasm Positive Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Mitotic Cell Cycle	Cytoplasmic Stress Granule Nucleus Cytoplasm RNA Cap Binding Eukaryotic Translation Initiation Factor 4F Complex Cytosol Calcium/calmodulin-dependent Protein Kinase Activity Extracellular Exosome RNA Binding Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Translation