RCHY1 and NLK

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		RCHY1	NLK
Description		ring finger and CHY zinc finger domain containing 1	nemo like kinase
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	P53 Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Protein Homodimerization Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Ubiquitin Protein Ligase Binding SH2 Domain Binding Metal Ion Binding Protein Serine Kinase Activity DNA-binding Transcription Factor Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Error-free Translesion Synthesis Rescue Of Stalled Ribosome	MAPK Cascade Regulation Of DNA-templated Transcription Protein Phosphorylation Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Regulation Of Signal Transduction Wnt Signaling Pathway Peptidyl-threonine Phosphorylation Negative Regulation Of Wnt Signaling Pathway Cellular Response To Nutrient Levels Cellular Response To Stress Intracellular Signal Transduction TORC1 Signaling Protein Stabilization Protein Localization To Lysosome Cellular Response To Osmotic Stress Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of Receptor Signaling Pathway Via STAT
Pathways		Translesion Synthesis by POLH Antigen processing: Ubiquitination & Proteasome degradation Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	Ca2+ pathway
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Response to tocilizumab in rheumatoid arthritis ( 22491018)	Non-response to bupropion and depression ( 27622933)
Interacting Genes		74 interacting genes: ADAMTSL4 AIG1 ANGPTL8 AOX1 AR ARF4 ATN1 AXIN1 BIRC3 CAMK2A CAMK2G CDK9 CDKN1B CHD8 CHEK2 COPE COX6C CREB5 CYBA DAPK1 DCUN1D5 F7 FADS6 GFI1B GORAB HOXA1 HOXA2 HOXA3 HOXB1 HOXB2 HOXB5 HOXC11 HOXC4 HOXD10 HRG KAT5 KLHL41 KRTAP9-2 LIMS2 MEOX2 MSH3 MT2A NKD2 NLK NOTCH2NLA PGLS PLAGL2 PMM1 PRDX4 RAB11A RBM38 RILP RPN2 SEMA4C SERPINA1 SERPINA5 SERTAD1 SRPRB TAOK2 TMBIM1 TMEM14C TMEM184A TP53 TP63 TP73 TRIM8 UBASH3B UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 WDR74 ZNF160	27 interacting genes: ASGR1 ATXN1 CREBBP CUL1 FBXW5 FOXO4 FOXP3 GRN HIPK2 KRTAP10-1 KRTAP10-3 KRTAP4-2 KRTAP5-6 KRTAP5-9 LEF1 MYB MYBL1 NDOR1 NOTCH1 QRICH1 RCHY1 RPTOR SDR16C5 SKP2 STAT3 USP4 ZHX3
Entrez ID		25898	51701
HPRD ID		07607	17637
Ensembl ID		ENSG00000163743	ENSG00000087095
Uniprot IDs		Q96PM5	Q9UBE8
PDB IDs		2JRJ 2K2C 2K2D 7YNX
Enriched GO Terms of Interacting Partners?		DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Embryonic Skeletal System Morphogenesis Regionalization Anterior/posterior Pattern Specification Skeletal System Morphogenesis Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Embryonic Organ Morphogenesis Positive Regulation Of Metabolic Process DNA-binding Transcription Factor Activity Pattern Specification Process Positive Regulation Of Transcription By RNA Polymerase II Signal Transduction By P53 Class Mediator Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Embryonic Morphogenesis Chromatin Positive Regulation Of Biosynthetic Process Rhombomere Development Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Sequence-specific Double-stranded DNA Binding Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Ubiquitin Conjugating Enzyme Activity Regulation Of Protein Localization To Plasma Membrane P53 Binding MDM2/MDM4 Family Protein Binding Skeletal System Development Regulation Of Macromolecule Biosynthetic Process Rhombomere 4 Development Developmental Process Nucleus Nucleoplasm Regulation Of Metabolic Process Ubiquitin Protein Ligase Binding Signal Transduction In Response To DNA Damage Rhombomere 3 Development Regulation Of Protein Localization To Cell Periphery Animal Organ Morphogenesis	Positive Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Cell Population Proliferation Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Intermediate Filament Response To Hypoxia Response To Decreased Oxygen Levels Positive Regulation Of RNA Metabolic Process Response To Oxygen Levels Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Regulation Of Cell Population Proliferation Positive Regulation Of Developmental Process T-helper 17 Type Immune Response Regulation Of Cell Development Negative Regulation Of RNA Metabolic Process Regulation Of Multicellular Organismal Development Cytosol Regulation Of Glial Cell Proliferation Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Cell Development Positive Regulation Of Cell Differentiation Negative Regulation Of Interleukin-4 Production Positive Regulation Of Odontoblast Differentiation RNA Polymerase II Transcription Regulator Complex Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process CD4-positive, Alpha-beta T Cell Differentiation Negative Regulation Of Interleukin-5 Production Positive Regulation Of Neuroepithelial Cell Differentiation Positive Regulation Of Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Cell Differentiation Regulation Of DNA-templated Transcription Cellular Response To Stress Regulation Of RNA Biosynthetic Process Transcription By RNA Polymerase II Leukocyte Activation Involved In Immune Response Cell Activation Involved In Immune Response SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Odontoblast Differentiation
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