RCHY1 and MSH3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		RCHY1	MSH3
Description		ring finger and CHY zinc finger domain containing 1	mutS homolog 3
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck	Nucleus Nucleoplasm Membrane MutSbeta Complex
	Molecular Function	P53 Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Protein Homodimerization Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding Enzyme Binding Mismatched DNA Binding Guanine/thymine Mispair Binding Dinucleotide Insertion Or Deletion Binding Single Guanine Insertion Binding Dinucleotide Repeat Insertion Binding Oxidized Purine DNA Binding Protein Homodimerization Activity ATP-dependent DNA Damage Sensor Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Error-free Translesion Synthesis Rescue Of Stalled Ribosome	DNA Repair Mismatch Repair Mitotic Recombination DNA Damage Response Somatic Recombination Of Immunoglobulin Gene Segments Maintenance Of DNA Repeat Elements Negative Regulation Of DNA Recombination
Pathways		Translesion Synthesis by POLH Antigen processing: Ubiquitination & Proteasome degradation Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Defective Mismatch Repair Associated With MSH3 Defective Mismatch Repair Associated With MSH2
Drugs
Diseases			Colorectal cancer
GWAS		Metabolite levels ( 23823483) Response to tocilizumab in rheumatoid arthritis ( 22491018)	Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) HDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Huntington's disease progression ( 28642124) Idiopathic downbeat nystagmus ( 32157568) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		74 interacting genes: ADAMTSL4 AIG1 ANGPTL8 AOX1 AR ARF4 ATN1 AXIN1 BIRC3 CAMK2A CAMK2G CDK9 CDKN1B CHD8 CHEK2 COPE COX6C CREB5 CYBA DAPK1 DCUN1D5 F7 FADS6 GFI1B GORAB HOXA1 HOXA2 HOXA3 HOXB1 HOXB2 HOXB5 HOXC11 HOXC4 HOXD10 HRG KAT5 KLHL41 KRTAP9-2 LIMS2 MEOX2 MSH3 MT2A NKD2 NLK NOTCH2NLA PGLS PLAGL2 PMM1 PRDX4 RAB11A RBM38 RILP RPN2 SEMA4C SERPINA1 SERPINA5 SERTAD1 SRPRB TAOK2 TMBIM1 TMEM14C TMEM184A TP53 TP63 TP73 TRIM8 UBASH3B UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 WDR74 ZNF160	14 interacting genes: BARD1 BRCA1 ERG EXO1 HUS1 MLH1 MSH2 PCNA RAD1 RAD9A RCHY1 SUMO2 TSC22D2 XPA
Entrez ID		25898	4437
HPRD ID		07607	02931
Ensembl ID		ENSG00000163743	ENSG00000113318
Uniprot IDs		Q96PM5	P20585
PDB IDs		2JRJ 2K2C 2K2D 7YNX	3THW 3THX 3THY 3THZ 8OLX 8OM5 8OM9 8OMA 8OMO 8OMQ 8R7C 8R7E 8R7V 8RZ7 8RZ8 8RZ9
Enriched GO Terms of Interacting Partners?		DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Embryonic Skeletal System Morphogenesis Regionalization Anterior/posterior Pattern Specification Skeletal System Morphogenesis Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Embryonic Organ Morphogenesis Positive Regulation Of Metabolic Process DNA-binding Transcription Factor Activity Pattern Specification Process Positive Regulation Of Transcription By RNA Polymerase II Signal Transduction By P53 Class Mediator Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Embryonic Morphogenesis Chromatin Positive Regulation Of Biosynthetic Process Rhombomere Development Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Sequence-specific Double-stranded DNA Binding Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Ubiquitin Conjugating Enzyme Activity Regulation Of Protein Localization To Plasma Membrane P53 Binding MDM2/MDM4 Family Protein Binding Skeletal System Development Regulation Of Macromolecule Biosynthetic Process Rhombomere 4 Development Developmental Process Nucleus Nucleoplasm Regulation Of Metabolic Process Ubiquitin Protein Ligase Binding Signal Transduction In Response To DNA Damage Rhombomere 3 Development Regulation Of Protein Localization To Cell Periphery Animal Organ Morphogenesis	DNA Repair DNA Metabolic Process DNA Damage Response Cellular Response To Radiation Response To Radiation Response To Ionizing Radiation Cellular Response To Stress Damaged DNA Binding Cellular Response To Ionizing Radiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Cell Cycle Checkpoint Clamp Complex Mismatch Repair DNA Damage Checkpoint Signaling Negative Regulation Of Cell Cycle Phase Transition Nucleic Acid Metabolic Process Postreplication Repair DNA Recombination Negative Regulation Of Cell Cycle Process Nucleoplasm Response To Stress Signal Transduction In Response To DNA Damage Somatic Hypermutation Of Immunoglobulin Genes DNA Strand Resection Involved In Replication Fork Processing Somatic Diversification Of Immune Receptors Via Somatic Mutation Nucleobase-containing Compound Metabolic Process Intrinsic Apoptotic Signaling Pathway Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Mitotic Intra-S DNA Damage Checkpoint Signaling Negative Regulation Of Mitotic Cell Cycle Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Macromolecule Metabolic Process Regulation Of Cell Cycle Phase Transition Isotype Switching Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Somatic Diversification Of Immunoglobulins Involved In Immune Response Dinucleotide Insertion Or Deletion Binding Somatic Recombination Of Immunoglobulin Gene Segments BRCA1-B Complex Homologous Recombination Guanine/thymine Mispair Binding Apoptotic Signaling Pathway Somatic Diversification Of Immunoglobulins Chromosome Organization Response To UV Somatic Cell DNA Recombination Regulation Of Cell Cycle
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