RCHY1 and PGLS

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		RCHY1	PGLS
Description		ring finger and CHY zinc finger domain containing 1	6-phosphogluconolactonase
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	P53 Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Protein Homodimerization Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Hydrolase Activity 6-phosphogluconolactonase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Error-free Translesion Synthesis Rescue Of Stalled Ribosome	Carbohydrate Metabolic Process Pentose-phosphate Shunt Pentose-phosphate Shunt, Oxidative Branch
Pathways		Translesion Synthesis by POLH Antigen processing: Ubiquitination & Proteasome degradation Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	Pentose phosphate pathway
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Response to tocilizumab in rheumatoid arthritis ( 22491018)
Interacting Genes		74 interacting genes: ADAMTSL4 AIG1 ANGPTL8 AOX1 AR ARF4 ATN1 AXIN1 BIRC3 CAMK2A CAMK2G CDK9 CDKN1B CHD8 CHEK2 COPE COX6C CREB5 CYBA DAPK1 DCUN1D5 F7 FADS6 GFI1B GORAB HOXA1 HOXA2 HOXA3 HOXB1 HOXB2 HOXB5 HOXC11 HOXC4 HOXD10 HRG KAT5 KLHL41 KRTAP9-2 LIMS2 MEOX2 MSH3 MT2A NKD2 NLK NOTCH2NLA PGLS PLAGL2 PMM1 PRDX4 RAB11A RBM38 RILP RPN2 SEMA4C SERPINA1 SERPINA5 SERTAD1 SRPRB TAOK2 TMBIM1 TMEM14C TMEM184A TP53 TP63 TP73 TRIM8 UBASH3B UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 WDR74 ZNF160	18 interacting genes: BLMH EWSR1 KLHL20 KRT31 KRT40 KRTAP10-3 KRTAP10-8 KRTAP10-9 KRTAP4-2 KRTAP5-9 MDFI NOTCH2NLA PLSCR1 POT1 RBPMS RCHY1 TERF1 TERF2IP
Entrez ID		25898	25796
HPRD ID		07607	12001
Ensembl ID		ENSG00000163743	ENSG00000130313
Uniprot IDs		Q96PM5	A0A0K0K1K7 O95336
PDB IDs		2JRJ 2K2C 2K2D 7YNX
Enriched GO Terms of Interacting Partners?		DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Embryonic Skeletal System Morphogenesis Regionalization Anterior/posterior Pattern Specification Skeletal System Morphogenesis Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Embryonic Organ Morphogenesis Positive Regulation Of Metabolic Process DNA-binding Transcription Factor Activity Pattern Specification Process Positive Regulation Of Transcription By RNA Polymerase II Signal Transduction By P53 Class Mediator Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Embryonic Morphogenesis Chromatin Positive Regulation Of Biosynthetic Process Rhombomere Development Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Sequence-specific Double-stranded DNA Binding Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Ubiquitin Conjugating Enzyme Activity Regulation Of Protein Localization To Plasma Membrane P53 Binding MDM2/MDM4 Family Protein Binding Skeletal System Development Regulation Of Macromolecule Biosynthetic Process Rhombomere 4 Development Developmental Process Nucleus Nucleoplasm Regulation Of Metabolic Process Ubiquitin Protein Ligase Binding Signal Transduction In Response To DNA Damage Rhombomere 3 Development Regulation Of Protein Localization To Cell Periphery Animal Organ Morphogenesis	Intermediate Filament Keratin Filament Shelterin Complex Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Telomere Capping Telomere Maintenance Via Telomerase DNA Biosynthetic Process RNA-templated DNA Biosynthetic Process Telomeric DNA Binding Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Telomeric D-loop Disassembly Positive Regulation Of Telomere Maintenance Telomeric Loop Disassembly Negative Regulation Of Chromosome Organization Telomere Maintenance Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Identical Protein Binding Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Organization Negative Regulation Of DNA Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Chromosome, Telomeric Region Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Type II Interferon Binding Regulation Of Telomere Maintenance Via Telomere Lengthening Cysteine-type Aminopeptidase Activity Structural Constituent Of Skin Epidermis Lead Ion Binding Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Regulation Of Chromosome Organization Positive Regulation Of Telomeric Loop Disassembly Protein K33-linked Ubiquitination Negative Regulation Of DNA Recombination At Telomere Cytosol Intermediate Filament Organization Phosphatidylserine Biosynthetic Process Mercury Ion Binding Phosphatidylserine Exposure On Apoptotic Cell Surface
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