RCHY1 and PGLS

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		RCHY1	PGLS
Gene Name		ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase	6-phosphogluconolactonase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Nuclear Speck	Cytosol Extracellular Vesicular Exosome
	Molecular Function	P53 Binding Ubiquitin-protein Transferase Activity Receptor Binding Protein Binding Zinc Ion Binding Ligase Activity Protein Homodimerization Activity	6-phosphogluconolactonase Activity Monosaccharide Binding
	Biological Process	Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination	Carbohydrate Metabolic Process Pentose-phosphate Shunt Pentose-phosphate Shunt, Oxidative Branch Pathogenesis Small Molecule Metabolic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Myoclonic epilepsy of Lafora Glycogen storage diseases Metabolism of carbohydrates Pentose phosphate pathway (hexose monophosphate shunt)
Drugs
Diseases
GWAS		Response to tocilizumab in rheumatoid arthritis ( 22491018)
Protein-Protein Interactions		61 interactors: ADAMTSL4 AIG1 AOX1 AR ARF4 ATN1 BIRC3 C19orf80 CAMK2A CAMK2G CDK9 CDKN1B CHD8 CHEK2 COPE COX6C CYBA DCUN1D5 F7 FADS6 GFI1B GORAB HRG KAT5 KLHL41 KRTAP9-2 LIMS2 MDM2 MEOX2 MSH3 MT2A NKD2 NLK NOTCH2NL PGLS PLAGL2 PMM1 PRDX4 RAB11A RBM38 RILP RPLP1 RPN2 SEMA4C SERPINA1 SERPINA5 SERTAD1 SRPRB TAOK2 TMBIM1 TMEM14C TMEM184A TP53 TP63 TP73 TRIM8 UBASH3B UBE2D2 UBE2D4 WDR74 ZNF160	16 interactors: EWSR1 KRT31 KRT40 KRTAP10-3 KRTAP10-8 KRTAP10-9 KRTAP4-2 KRTAP5-9 MDFI NOTCH2NL PLSCR1 POT1 RBPMS RCHY1 TERF1 TERF2IP
Entrez ID		25898	25796
HPRD ID		07607	12001
Ensembl ID		ENSG00000163743	ENSG00000130313
Uniprot IDs		C7E542 E7EMC8 E7ETW5 J3KPI0 Q96PM5	O95336
PDB IDs		2JRJ 2K2C 2K2D
Enriched GO Terms of Interacting Partners?		Signal Transduction In Response To DNA Damage DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription DNA Damage Response, Signal Transduction By P53 Class Mediator Mitotic DNA Damage Checkpoint DNA Damage Checkpoint Mitotic DNA Integrity Checkpoint Signal Transduction By P53 Class Mediator Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Regulation Of Protein Metabolic Process Response To Stress Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Mitotic Cell Cycle Checkpoint Response To Gamma Radiation Negative Regulation Of Cellular Metabolic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Cellular Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Cellular Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Apoptotic Process Negative Regulation Of Mitotic Cell Cycle Response To Ionizing Radiation Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cellular Protein Metabolic Process Cellular Response To Stress Negative Regulation Of Biosynthetic Process Regulation Of Cell Cycle Process Regulation Of Cell Death Regulation Of Metabolic Process Regulation Of Cell Cycle Arrest Mitotic Cell Cycle Process Cellular Response To DNA Damage Stimulus Cell Cycle Process Positive Regulation Of Metabolic Process Cell Death Death Regulation Of Mitotic Cell Cycle Regulation Of Cellular Process Response To Abiotic Stimulus Positive Regulation Of Blood Vessel Remodeling Negative Regulation Of Apoptotic Process Regulation Of Body Fluid Levels Negative Regulation Of Programmed Cell Death	Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance RNA-dependent DNA Replication Telomere Maintenance Via Telomere Lengthening Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Negative Regulation Of Chromosome Organization Negative Regulation Of Telomerase Activity Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of DNA Metabolic Process Regulation Of Telomerase Activity Negative Regulation Of DNA Biosynthetic Process Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication DNA Replication Positive Regulation Of DNA Strand Elongation Negative Regulation Of DNA Recombination At Telomere Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomeric Loop Formation Age-dependent Telomere Shortening Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Telomere Formation Via Telomerase Regulation Of DNA Replication Telomere Maintenance Via Telomere Shortening Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protection From Non-homologous End Joining At Telomere Regulation Of Nitrogen Compound Metabolic Process Protein Localization To Chromosome, Telomeric Region Positive Regulation Of Helicase Activity Phosphatidylserine Biosynthetic Process Regulation Of Protein Import Into Nucleus Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Telomerase Activity Telomere Assembly Positive Regulation Of Telomere Maintenance Via Telomerase Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Localization To Nucleus Positive Regulation Of Cellular Metabolic Process Regulation Of Nucleocytoplasmic Transport Replicative Cell Aging Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Nuclear Cell Cycle DNA Replication Phospholipid Scrambling Positive Regulation Of Telomere Maintenance Regulation Of Metabolic Process Regulation Of Intracellular Protein Transport
Tagcloud ?		20s alters animal conserved correlatively crucial degradation display e3 establish handful homeodomain hox hoxa2 interacts ligase modes multitude pirh2 promotes proteasomal proteasome regulators reports reveal stabilization subunits ubiquitin ubiquitination	100ng 1r 24h antidiabetic ap consisting elicited expressions extensively granulosa incubated insr insulin irs kappabreporter luciferase lutein mek metformin ovary p70 pdk1 phosphoinositide polycystic porcine raf rapamycin steroidogenesis tor
Tagcloud (Difference) ?		20s alters animal conserved correlatively crucial degradation display e3 establish handful homeodomain hox hoxa2 interacts ligase modes multitude pirh2 promotes proteasomal proteasome regulators reports reveal stabilization subunits ubiquitin ubiquitination	100ng 1r 24h antidiabetic ap consisting elicited expressions extensively granulosa incubated insr insulin irs kappabreporter luciferase lutein mek metformin ovary p70 pdk1 phosphoinositide polycystic porcine raf rapamycin steroidogenesis tor
Tagcloud (Intersection) ?