RCHY1 and SERTAD1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		RCHY1	SERTAD1
Description		ring finger and CHY zinc finger domain containing 1	SERTA domain containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck	Nucleus Cytoplasm Sarcoplasm
	Molecular Function	P53 Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Protein Homodimerization Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Transcription Coactivator Activity Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Error-free Translesion Synthesis Rescue Of Stalled Ribosome	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Population Proliferation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Translesion Synthesis by POLH Antigen processing: Ubiquitination & Proteasome degradation Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Response to tocilizumab in rheumatoid arthritis ( 22491018)	Monocyte percentage of white cells ( 32888494) Otitis media ( 27632927) Otitis media (chronic) ( 27632927) Otitis media (recurrent) ( 27632927)
Interacting Genes		74 interacting genes: ADAMTSL4 AIG1 ANGPTL8 AOX1 AR ARF4 ATN1 AXIN1 BIRC3 CAMK2A CAMK2G CDK9 CDKN1B CHD8 CHEK2 COPE COX6C CREB5 CYBA DAPK1 DCUN1D5 F7 FADS6 GFI1B GORAB HOXA1 HOXA2 HOXA3 HOXB1 HOXB2 HOXB5 HOXC11 HOXC4 HOXD10 HRG KAT5 KLHL41 KRTAP9-2 LIMS2 MEOX2 MSH3 MT2A NKD2 NLK NOTCH2NLA PGLS PLAGL2 PMM1 PRDX4 RAB11A RBM38 RILP RPN2 SEMA4C SERPINA1 SERPINA5 SERTAD1 SRPRB TAOK2 TMBIM1 TMEM14C TMEM184A TP53 TP63 TP73 TRIM8 UBASH3B UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 WDR74 ZNF160	56 interacting genes: ADCY1 AIRIM ASB8 ATG12 ATXN7L3 BANF2 CCND2 CDK4 CDKN2A CHAF1A CHURC1 CIB3 CINP CKS1B COPB1 CREBBP DENND4A EGLN3 ELOC EP300 FAAP20 FAH FNDC11 FXR1 GLYCTK HIVEP1 HSPB1 KAT2B KLC4 KLHL42 MVP P4HA3 PATE1 PBX4 PICK1 PIH1D2 POT1 PRDM4 PSORS1C2 RBX1 RCHY1 ROPN1 SEC14L4 SETD7 SFI1 SMAD3 SPEN SSX7 STAT5B SUPT7L TGM2 TLR4 TRIM28 TSC1 XIAP ZNF410
Entrez ID		25898	29950
HPRD ID		07607	15326
Ensembl ID		ENSG00000163743	ENSG00000197019
Uniprot IDs		Q96PM5	Q53GC0 Q9UHV2
PDB IDs		2JRJ 2K2C 2K2D 7YNX
Enriched GO Terms of Interacting Partners?		DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Embryonic Skeletal System Morphogenesis Regionalization Anterior/posterior Pattern Specification Skeletal System Morphogenesis Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Embryonic Organ Morphogenesis Positive Regulation Of Metabolic Process DNA-binding Transcription Factor Activity Pattern Specification Process Positive Regulation Of Transcription By RNA Polymerase II Signal Transduction By P53 Class Mediator Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Embryonic Morphogenesis Chromatin Positive Regulation Of Biosynthetic Process Rhombomere Development Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Sequence-specific Double-stranded DNA Binding Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Ubiquitin Conjugating Enzyme Activity Regulation Of Protein Localization To Plasma Membrane P53 Binding MDM2/MDM4 Family Protein Binding Skeletal System Development Regulation Of Macromolecule Biosynthetic Process Rhombomere 4 Development Developmental Process Nucleus Nucleoplasm Regulation Of Metabolic Process Ubiquitin Protein Ligase Binding Signal Transduction In Response To DNA Damage Rhombomere 3 Development Regulation Of Protein Localization To Cell Periphery Animal Organ Morphogenesis	N-terminal Peptidyl-lysine Acetylation Positive Regulation Of Macromolecule Biosynthetic Process P53 Binding Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Response To Stress RNA Polymerase II-specific DNA-binding Transcription Factor Binding Peptidyl-lysine Acetylation N-terminal Protein Amino Acid Acetylation Histone H3K27 Acetyltransferase Activity Regulation Of DNA Repair Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Protein Localization To Nucleus Protein Binding Cellular Response To Stress Cyclin D2-CDK4 Complex Acetyltransferase Activity Histone H3K18 Acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Nucleus Protein Modification Process DNA Damage Response Canonical NF-kappaB Signal Transduction Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Histone Acetyltransferase Complex Transcription Coregulator Activity SAGA Complex Protein-lysine-acetyltransferase Activity Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Stabilization Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Chromatin Regulation Of Protein Localization To Nucleus Chromatin Binding Histone Acetyltransferase Activity L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Chromo Shadow Domain Binding Protein Acetylation Cellular Response To Nutrient Levels Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Histone H3 Acetyltransferase Activity Internal Peptidyl-lysine Acetylation Positive Regulation Of Protein Import Into Nucleus
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