RCHY1 and AOX1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		RCHY1	AOX1
Description		ring finger and CHY zinc finger domain containing 1	aldehyde oxidase 1
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck	Cytoplasm Cytosol Microtubule Cytoskeleton Nuclear Body Intercellular Bridge Extracellular Exosome
	Molecular Function	P53 Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Protein Homodimerization Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Aldehyde Oxidase Activity Iron Ion Binding Oxidoreductase Activity Identical Protein Binding Protein Homodimerization Activity Molybdopterin Cofactor Binding Metal Ion Binding Flavin Adenine Dinucleotide Binding NAD Binding Iron-sulfur Cluster Binding 2 Iron, 2 Sulfur Cluster Binding FAD Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Error-free Translesion Synthesis Rescue Of Stalled Ribosome	Lipid Metabolic Process Xenobiotic Metabolic Process
Pathways		Translesion Synthesis by POLH Antigen processing: Ubiquitination & Proteasome degradation Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	Vitamin B6 activation to pyridoxal phosphate
Drugs			Cyclobenzaprine Eniluracil
Diseases			Xanthinuria
GWAS		Metabolite levels ( 23823483) Response to tocilizumab in rheumatoid arthritis ( 22491018)	Hip circumference adjusted for BMI ( 28552196) Intelligence ( 22449649) Late-onset Alzheimer's disease ( 27770636)
Interacting Genes		74 interacting genes: ADAMTSL4 AIG1 ANGPTL8 AOX1 AR ARF4 ATN1 AXIN1 BIRC3 CAMK2A CAMK2G CDK9 CDKN1B CHD8 CHEK2 COPE COX6C CREB5 CYBA DAPK1 DCUN1D5 F7 FADS6 GFI1B GORAB HOXA1 HOXA2 HOXA3 HOXB1 HOXB2 HOXB5 HOXC11 HOXC4 HOXD10 HRG KAT5 KLHL41 KRTAP9-2 LIMS2 MEOX2 MSH3 MT2A NKD2 NLK NOTCH2NLA PGLS PLAGL2 PMM1 PRDX4 RAB11A RBM38 RILP RPN2 SEMA4C SERPINA1 SERPINA5 SERTAD1 SRPRB TAOK2 TMBIM1 TMEM14C TMEM184A TP53 TP63 TP73 TRIM8 UBASH3B UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 WDR74 ZNF160	6 interacting genes: ABCA1 CRKL ERRFI1 GK RBL1 RCHY1
Entrez ID		25898	316
HPRD ID		07607	07537
Ensembl ID		ENSG00000163743	ENSG00000138356
Uniprot IDs		Q96PM5	Q06278
PDB IDs		2JRJ 2K2C 2K2D 7YNX	4UHW 4UHX 5EPG 6Q6Q 7OPN 7ORC 8EMT
Enriched GO Terms of Interacting Partners?		DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Embryonic Skeletal System Morphogenesis Regionalization Anterior/posterior Pattern Specification Skeletal System Morphogenesis Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Embryonic Organ Morphogenesis Positive Regulation Of Metabolic Process DNA-binding Transcription Factor Activity Pattern Specification Process Positive Regulation Of Transcription By RNA Polymerase II Signal Transduction By P53 Class Mediator Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Embryonic Morphogenesis Chromatin Positive Regulation Of Biosynthetic Process Rhombomere Development Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Sequence-specific Double-stranded DNA Binding Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Ubiquitin Conjugating Enzyme Activity Regulation Of Protein Localization To Plasma Membrane P53 Binding MDM2/MDM4 Family Protein Binding Skeletal System Development Regulation Of Macromolecule Biosynthetic Process Rhombomere 4 Development Developmental Process Nucleus Nucleoplasm Regulation Of Metabolic Process Ubiquitin Protein Ligase Binding Signal Transduction In Response To DNA Damage Rhombomere 3 Development Regulation Of Protein Localization To Cell Periphery Animal Organ Morphogenesis	Response To Vitamin B3 Lipid Metabolic Process Response To Xenobiotic Stimulus Apolipoprotein A-I-mediated Signaling Pathway Sterol Metabolic Process Floppase Activity Regulation Of High-density Lipoprotein Particle Assembly Cholesterol Metabolic Process Sterol Homeostasis Sphingolipid Translocation Alcohol Metabolic Process Positive Regulation Of High-density Lipoprotein Particle Assembly Cellular Response To Xenobiotic Stimulus Apolipoprotein A-I Receptor Activity Apolipoprotein A-I Binding Phosphatidylserine Floppase Activity Sphingolipid Floppase Activity Cholesterol Homeostasis Protein Insertion Into Mitochondrial Inner Membrane From Matrix Helper T Cell Diapedesis Chordate Pharynx Development T Cell Receptor Signaling Pathway Nuclear Receptor-mediated Signaling Pathway Cerebellar Neuron Development Antigen Receptor-mediated Signaling Pathway Hormone-mediated Signaling Pathway Protein Complex Involved In Cell Adhesion Glycerol Catabolic Process Glycerol-3-phosphate Metabolic Process Glycerol Kinase Activity Glycerol-3-phosphate Biosynthetic Process Regulation Of Lipid Kinase Activity Error-free Translesion Synthesis Negative Regulation Of Protein Autophosphorylation Oviduct Epithelium Development Uterine Epithelium Development Response To 1-oleoyl-sn-glycerol 3-phosphate Lipoprotein Biosynthetic Process Phosphatidylcholine Floppase Activity Lipid Homeostasis Parathyroid Gland Development Negative Regulation Of Regulatory T Cell Differentiation
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