RCHY1 and COX6C

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		RCHY1	COX6C
Description		ring finger and CHY zinc finger domain containing 1	cytochrome c oxidase subunit 6C
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Membrane Mitochondrial Membrane Respiratory Chain Complex IV
	Molecular Function	P53 Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Protein Homodimerization Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Error-free Translesion Synthesis Rescue Of Stalled Ribosome	Generation Of Precursor Metabolites And Energy Oxidative Phosphorylation Mitochondrial Electron Transport, Cytochrome C To Oxygen Cellular Respiration
Pathways		Translesion Synthesis by POLH Antigen processing: Ubiquitination & Proteasome degradation Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	TP53 Regulates Metabolic Genes Respiratory electron transport Cytoprotection by HMOX1 Complex IV assembly
Drugs			Cholic Acid N-Formylmethionine
Diseases
GWAS		Metabolite levels ( 23823483) Response to tocilizumab in rheumatoid arthritis ( 22491018)	Glucose homeostasis traits ( 25524916) Leukocyte telomere length ( 32109421)
Interacting Genes		74 interacting genes: ADAMTSL4 AIG1 ANGPTL8 AOX1 AR ARF4 ATN1 AXIN1 BIRC3 CAMK2A CAMK2G CDK9 CDKN1B CHD8 CHEK2 COPE COX6C CREB5 CYBA DAPK1 DCUN1D5 F7 FADS6 GFI1B GORAB HOXA1 HOXA2 HOXA3 HOXB1 HOXB2 HOXB5 HOXC11 HOXC4 HOXD10 HRG KAT5 KLHL41 KRTAP9-2 LIMS2 MEOX2 MSH3 MT2A NKD2 NLK NOTCH2NLA PGLS PLAGL2 PMM1 PRDX4 RAB11A RBM38 RILP RPN2 SEMA4C SERPINA1 SERPINA5 SERTAD1 SRPRB TAOK2 TMBIM1 TMEM14C TMEM184A TP53 TP63 TP73 TRIM8 UBASH3B UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 WDR74 ZNF160	4 interacting genes: PHB1 PTN RCHY1 SAT1
Entrez ID		25898	1345
HPRD ID		07607	00494
Ensembl ID		ENSG00000163743	ENSG00000164919
Uniprot IDs		Q96PM5	A0A024R9B7 P09669
PDB IDs		2JRJ 2K2C 2K2D 7YNX	5Z62
Enriched GO Terms of Interacting Partners?		DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Embryonic Skeletal System Morphogenesis Regionalization Anterior/posterior Pattern Specification Skeletal System Morphogenesis Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Embryonic Organ Morphogenesis Positive Regulation Of Metabolic Process DNA-binding Transcription Factor Activity Pattern Specification Process Positive Regulation Of Transcription By RNA Polymerase II Signal Transduction By P53 Class Mediator Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Embryonic Morphogenesis Chromatin Positive Regulation Of Biosynthetic Process Rhombomere Development Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Sequence-specific Double-stranded DNA Binding Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Ubiquitin Conjugating Enzyme Activity Regulation Of Protein Localization To Plasma Membrane P53 Binding MDM2/MDM4 Family Protein Binding Skeletal System Development Regulation Of Macromolecule Biosynthetic Process Rhombomere 4 Development Developmental Process Nucleus Nucleoplasm Regulation Of Metabolic Process Ubiquitin Protein Ligase Binding Signal Transduction In Response To DNA Damage Rhombomere 3 Development Regulation Of Protein Localization To Cell Periphery Animal Organ Morphogenesis	DNA Biosynthetic Process Mitochondrial Prohibitin Complex Complement Component C3a Binding Dendrite Regeneration Spermidine Acetylation Putrescine Catabolic Process Spermidine Binding Proteinase Activated Receptor Binding Ossification Involved In Bone Remodeling Diamine N-acetyltransferase Activity Polyamine Catabolic Process T-helper 17 Type Immune Response Error-free Translesion Synthesis Positive Regulation Of Complement Activation Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Host-mediated Perturbation Of Viral RNA Genome Replication RIG-I Signaling Pathway Positive Regulation Of Axon Regeneration Leukocyte Chemotaxis Involved In Inflammatory Response Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Spermidine Metabolic Process Putrescine Metabolic Process Regulation Of Protein Catabolic Process Progesterone Receptor Signaling Pathway Complement Component C3b Binding Dendrite Arborization Negative Regulation Of Long-term Synaptic Potentiation Chondroitin Sulfate Binding Positive Regulation Of Hepatocyte Proliferation Estrous Cycle Negative Regulation Of Transcription By Competitive Promoter Binding Negative Regulation Of Neuroblast Proliferation Regulation Of Cell Population Proliferation Regulation Of Hepatocyte Proliferation Positive Regulation Of Dendrite Development Polyamine Biosynthetic Process N-acetyltransferase Activity Cellular Response To Interleukin-6 Negative Regulation Of Androgen Receptor Signaling Pathway Ovulation Cycle Polyamine Metabolic Process Response To Interleukin-6 Neuron Projection Arborization Response To Auditory Stimulus Leukocyte Migration Involved In Inflammatory Response Positive Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Humoral Immune Response Positive Regulation Of Stem Cell Differentiation Regulation Of Complement Activation Decidualization
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