RCHY1 and CHD8

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		RCHY1	CHD8
Description		ring finger and CHY zinc finger domain containing 1	chromodomain helicase DNA binding protein 8
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck	Chromatin Nucleus Nucleoplasm Protein-containing Complex MLL1 Complex
	Molecular Function	P53 Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Protein Homodimerization Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding P53 Binding DNA Binding DNA Helicase Activity Chromatin Binding Protein Binding ATP Binding Beta-catenin Binding ATP-dependent Activity, Acting On DNA Hydrolase Activity ATP Hydrolysis Activity Histone Binding Histone H3K4me3 Reader Activity ATP-dependent Chromatin Remodeler Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Error-free Translesion Synthesis Rescue Of Stalled Ribosome	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Startle Response Chromatin Organization Chromatin Remodeling MRNA Processing Brain Development Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Social Behavior Negative Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase III Digestive Tract Development Prepulse Inhibition Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Fibroblast Apoptotic Process
Pathways		Translesion Synthesis by POLH Antigen processing: Ubiquitination & Proteasome degradation Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	Deactivation of the beta-catenin transactivating complex
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Response to tocilizumab in rheumatoid arthritis ( 22491018)	Appendicular lean mass ( 33097823) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		74 interacting genes: ADAMTSL4 AIG1 ANGPTL8 AOX1 AR ARF4 ATN1 AXIN1 BIRC3 CAMK2A CAMK2G CDK9 CDKN1B CHD8 CHEK2 COPE COX6C CREB5 CYBA DAPK1 DCUN1D5 F7 FADS6 GFI1B GORAB HOXA1 HOXA2 HOXA3 HOXB1 HOXB2 HOXB5 HOXC11 HOXC4 HOXD10 HRG KAT5 KLHL41 KRTAP9-2 LIMS2 MEOX2 MSH3 MT2A NKD2 NLK NOTCH2NLA PGLS PLAGL2 PMM1 PRDX4 RAB11A RBM38 RILP RPN2 SEMA4C SERPINA1 SERPINA5 SERTAD1 SRPRB TAOK2 TMBIM1 TMEM14C TMEM184A TP53 TP63 TP73 TRIM8 UBASH3B UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 WDR74 ZNF160	12 interacting genes: AR CEBPA CHD7 CREB1 CTCF CTNNB1 MYC RBBP5 RCHY1 SUMO2 TOP3B WDR5
Entrez ID		25898	57680
HPRD ID		07607	16712
Ensembl ID		ENSG00000163743	ENSG00000100888
Uniprot IDs		Q96PM5	Q9HCK8
PDB IDs		2JRJ 2K2C 2K2D 7YNX	2CKA 2DL6
Enriched GO Terms of Interacting Partners?		DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Embryonic Skeletal System Morphogenesis Regionalization Anterior/posterior Pattern Specification Skeletal System Morphogenesis Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Embryonic Organ Morphogenesis Positive Regulation Of Metabolic Process DNA-binding Transcription Factor Activity Pattern Specification Process Positive Regulation Of Transcription By RNA Polymerase II Signal Transduction By P53 Class Mediator Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Embryonic Morphogenesis Chromatin Positive Regulation Of Biosynthetic Process Rhombomere Development Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Sequence-specific Double-stranded DNA Binding Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Ubiquitin Conjugating Enzyme Activity Regulation Of Protein Localization To Plasma Membrane P53 Binding MDM2/MDM4 Family Protein Binding Skeletal System Development Regulation Of Macromolecule Biosynthetic Process Rhombomere 4 Development Developmental Process Nucleus Nucleoplasm Regulation Of Metabolic Process Ubiquitin Protein Ligase Binding Signal Transduction In Response To DNA Damage Rhombomere 3 Development Regulation Of Protein Localization To Cell Periphery Animal Organ Morphogenesis	DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Transcription Cis-regulatory Region Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Biosynthetic Process Nucleoplasm Macromolecule Biosynthetic Process Transcription By RNA Polymerase II Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Transcription Coregulator Binding Regulation Of Transcription By RNA Polymerase II Regulation Of Centromeric Sister Chromatid Cohesion Nucleus RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Euchromatin Chromatin Binding Nucleic Acid Metabolic Process Negative Regulation Of RNA Metabolic Process Epithelial Cell Differentiation Involved In Prostate Gland Development Positive Regulation Of DNA-templated Transcription Initiation MLL1/2 Complex In Utero Embryonic Development Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Chordate Embryonic Development Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of DNA-templated Transcription Initiation Regulation Of DNA-templated Transcription Genitalia Morphogenesis Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Epigenetic Regulation Of Gene Expression MLL3/4 Complex Regulation Of Fibroblast Proliferation Response To Xenobiotic Stimulus Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation
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