KLK5 and NOTCH2

Number of citations of the paper that reports this interaction (PubMedID 25640309)
0

Data Source:
BioGRID (two hybrid)

		KLK5	NOTCH2
Description		kallikrein related peptidase 5	notch receptor 2
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Secretory Granule Epidermal Lamellar Body	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Cilium Cell Surface Membrane Receptor Complex
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	Transcription Coactivator Activity Calcium Ion Binding Protein Binding Enzyme Binding Signaling Receptor Activity NF-kappaB Binding
	Biological Process	Positive Regulation Of Antibacterial Peptide Production Proteolysis Epidermis Development Extracellular Matrix Disassembly Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Protein Maturation Cornification Amelogenesis	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Cell Fate Determination Liver Development Placenta Development Heart Looping Morphogenesis Of An Epithelial Sheet Marginal Zone B Cell Differentiation Inflammatory Response To Antigenic Stimulus Atrioventricular Node Development Pulmonary Valve Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Humoral Immune Response Notch Signaling Pathway Determination Of Left/right Symmetry Nervous System Development Axon Guidance Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Keratinocyte Proliferation Hemopoiesis Cell Differentiation Embryonic Limb Morphogenesis BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Multicellular Organism Growth Intracellular Signal Transduction Intrahepatic Bile Duct Development Wound Healing Defense Response To Bacterium Regulation Of Apoptotic Process Myeloid Dendritic Cell Differentiation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Ras Protein Signal Transduction Bone Remodeling Regulation Of Developmental Process Positive Regulation Of Smooth Muscle Cell Differentiation Cardiac Septum Morphogenesis Atrial Septum Morphogenesis Placenta Blood Vessel Development Ciliary Body Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Left/right Axis Specification Cellular Response To Tumor Cell Proximal Tubule Development Podocyte Development Glomerular Capillary Formation Hepatocyte Proliferation Liver Morphogenesis Positive Regulation Of MiRNA Transcription Regulation Of Hemopoiesis Cholangiocyte Proliferation Regulation Of Osteoclast Development
Pathways		Formation of the cornified envelope Formation of the cornified envelope Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Transcription and Translation Pre-NOTCH Processing in Golgi Pre-NOTCH Processing in Golgi NOTCH2 intracellular domain regulates transcription NOTCH2 intracellular domain regulates transcription NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH2 Activation and Transmission of Signal to the Nucleus Notch-HLH transcription pathway Defective LFNG causes SCDO3 NOTCH4 Intracellular Domain Regulates Transcription
Drugs
Diseases			Alagille syndrome Hajdu-Cheney syndrome Type II diabetes mellitus
GWAS			Blood protein levels ( 30072576) Hepatocyte growth factor levels ( 25998175) Nevus count or cutaneous melanoma ( 32341527) Systemic lupus erythematosus ( 28714469) Type 1 diabetes ( 34012112 34127860) Type 2 diabetes ( 18372903 30054458 30297969)
Interacting Genes		12 interacting genes: AURKA BAG4 CASP8 DSG1 ERBB2 ESR1 IGF1R MANBAL NOTCH2 SERPINA1 TGFB1 TSG101	31 interacting genes: ANKRD28 CCR2 CNTN1 CRKL CST6 DLL1 DTX1 DTX3 EGFL7 EPSTI1 GSK3B IL13RA2 IL24 ITIH5 JAG1 JAG2 KLK5 LFNG LRATD2 MAML1 MAML2 MAML3 MFNG MTA3 MYOC PSEN1 PSEN2 PSMC3IP RBPJ SHANK3 SMAD1
Entrez ID		25818	4853
HPRD ID		05732	02606
Ensembl ID		ENSG00000167754	ENSG00000134250
Uniprot IDs		Q9Y337	Q04721 Q6IQ50
PDB IDs		2PSX 2PSY 6QFE 7U5B	2OO4 5MWB
Enriched GO Terms of Interacting Partners?		Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Positive Regulation Of Myeloid Leukocyte Differentiation Negative Regulation Of Apoptotic Process Response To Wounding Regulation Of MiRNA Transcription Regulation Of Signal Transduction Regulation Of MiRNA Metabolic Process Positive Regulation Of Macrophage Differentiation Response To Estradiol Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Ubiquitin Protein Ligase Binding Positive Regulation Of Myeloid Cell Differentiation Regulation Of Signaling Plasma Membrane Branch Elongation Of An Epithelium Liver Development Positive Regulation Of Fibroblast Migration Axis Elongation Protein-containing Complex Binding Branching Involved In Mammary Gland Duct Morphogenesis Regulation Of Myeloid Leukocyte Differentiation Developmental Growth Developmental Growth Involved In Morphogenesis Myeloid Dendritic Cell Differentiation Positive Regulation Of Smooth Muscle Cell Differentiation Myeloid Leukocyte Differentiation Regulation Of Macrophage Differentiation Positive Regulation Of Cell Development Regulation Of Cell Development Regulation Of Hemopoiesis Animal Organ Development Negative Regulation Of MiRNA Transcription Myeloid Dendritic Cell Activation Gland Morphogenesis Liver Regeneration Lymphocyte Activation Positive Regulation Of MAPK Cascade Plasma Membrane Bounded Cell Projection Organization Maternal Process Involved In Female Pregnancy Epithelial Cell Proliferation Positive Regulation Of Cell Population Proliferation Response To Progesterone Positive Regulation Of Leukocyte Differentiation Receptor Complex Positive Regulation Of Epithelial Cell Proliferation Dendritic Cell Differentiation	Notch Signaling Pathway Regulation Of Notch Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Positive Regulation Of Notch Signaling Pathway Notch Binding Mononuclear Cell Differentiation Regulation Of Cell Adhesion Lymphocyte Differentiation Leukocyte Differentiation Marginal Zone B Cell Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Timing Of Cell Differentiation Positive Regulation Of Signaling Lymphocyte Activation Somitogenesis Regulation Of Development, Heterochronic Signal Transduction Segmentation O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Activity Positive Regulation Of Signal Transduction Cellular Developmental Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Leukocyte Activation Cell Differentiation Pattern Specification Process MAML1-RBP-Jkappa- ICN1 Complex Blood Vessel Endothelial Cell Fate Specification Auditory Receptor Cell Fate Commitment Negative Regulation Of Neuron Differentiation Positive Regulation Of Cell Communication Positive Regulation Of RNA Metabolic Process Anterior/posterior Pattern Specification Positive Regulation Of Macromolecule Metabolic Process Anatomical Structure Formation Involved In Morphogenesis Transcription Coactivator Activity Immune System Process Endothelial Cell Fate Specification Compartment Pattern Specification Mature B Cell Differentiation Involved In Immune Response Cell Activation Myoblast Differentiation Regulation Of Cell Population Proliferation Mature B Cell Differentiation Loop Of Henle Development Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Signal Transduction Animal Organ Morphogenesis
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