KLK5 and SERPINA1

Number of citations of the paper that reports this interaction (PMID 12890555)
4

Data Source:
HPRD (in vitro)

		KLK5	SERPINA1
Gene Name		kallikrein-related peptidase 5	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Epidermal Lamellar Body	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Endoplasmic Reticulum Golgi Apparatus Platelet Alpha Granule Lumen Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity	Glycoprotein Binding Protease Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Identical Protein Binding
	Biological Process	Proteolysis Epidermis Development Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway	Response To Hypoxia Platelet Degranulation Acute-phase Response Blood Coagulation Response To Lead Ion Negative Regulation Of Endopeptidase Activity Platelet Activation Response To Estradiol Response To Lipopolysaccharide Response To Methanol Response To Triglyceride Response To Cytokine Response To Chromate Negative Regulation Of Serine-type Endopeptidase Activity
Pathways			Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation
Drugs			2-[3,4-Dihydroxy-2-Hydroxymethyl-5-(2-Hydroxy-Nonyl)-Tetrahydro-Furan-2-Yloxy]-6-Hydroxymethyl-Tetra Hydro-Pyran-3,4,5-Triol Beta-Mercaptoethanol
Diseases
GWAS			Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Metabolite levels ( 22916037)
Protein-Protein Interactions		2 interactors: DSG1 SERPINA1	26 interactors: ADAMTS4 ATP5C1 CELA1 CTRB1 CTSG DERL2 DERL3 ECHS1 ELANE GSDMB KLK13 KLK3 KLK5 LRP1 MMP11 MMP26 MMP7 PRSS1 PRSS2 PRSS3 PRTN3 RAP2A RCHY1 SDC2 SMAD4 VKORC1
Entrez ID		25818	5265
HPRD ID		05732	02463
Ensembl ID		ENSG00000167754	ENSG00000197249
Uniprot IDs		Q9Y337	E9KL23 P01009
PDB IDs		2PSX 2PSY	1ATU 1D5S 1EZX 1HP7 1IZ2 1KCT 1OO8 1OPH 1PSI 1QLP 1QMB 2D26 2QUG 3CWL 3CWM 3DRM 3DRU 3NDD 3NDF 3NE4 3T1P 7API 8API 9API
Enriched GO Terms of Interacting Partners?		Response To Methanol Response To Triglyceride Response To Chromate Response To Steroid Hormone Negative Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Serine-type Peptidase Activity Response To Lipid Response To Organic Cyclic Compound Response To Hormone Response To Lead Ion Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Acute-phase Response Response To Progesterone Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Platelet Degranulation Execution Phase Of Apoptosis Acute Inflammatory Response Maternal Process Involved In Female Pregnancy Protein Stabilization Cell-cell Junction Assembly Response To Estradiol Response To Organic Substance Regulation Of Protein Stability	Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Collagen Catabolic Process Collagen Metabolic Process Protein Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Catabolic Process Cobalamin Metabolic Process Metabolic Process Response To Stress Vitamin Metabolic Process Digestion Killing By Host Of Symbiont Cells Defense Response Defense Response To Bacterium Tetrapyrrole Metabolic Process Water-soluble Vitamin Metabolic Process Protein Processing Neutrophil Mediated Immunity Killing Of Cells Of Other Organism Negative Regulation Of Growth Of Symbiont In Host Regulation Of Growth Defense Response To Fungus Interaction With Symbiont Leukocyte Mediated Cytotoxicity ER-associated Ubiquitin-dependent Protein Catabolic Process Response To Fungus Antibacterial Peptide Secretion Antibacterial Peptide Biosynthetic Process Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Beta-amyloid Clearance Response To Bacterium Small Molecule Metabolic Process Response To External Stimulus Negative Regulation Of Growth Negative Regulation Of Locomotion Response To Stimulus Factor XII Activation Nephrogenic Mesenchyme Morphogenesis Neutrophil Mediated Killing Of Gram-positive Bacterium Neutrophil Mediated Killing Of Fungus Defense Response To Gram-positive Bacterium Regulation Of Dendrite Morphogenesis Regulation Of Cellular Component Organization Acute Inflammatory Response Phototransduction, Visible Light Wound Healing
Tagcloud ?		bag1 bcl2l2 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 map2k7 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 serpinb5 serpine1 thbs1 thbs2	abundantly adam10 amyloidophilic annular assemblies bace2 carries congo congophilia congophilic contributor dot generic iatrogenic join misfolding misfoldome pathophysiologic placentas preeclampsia prefibrillar presenilin proteoforms protofibrils prototype secretases shares supramolecular
Tagcloud (Difference) ?		bag1 bcl2l2 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 map2k7 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 serpinb5 serpine1 thbs1 thbs2	abundantly adam10 amyloidophilic annular assemblies bace2 carries congo congophilia congophilic contributor dot generic iatrogenic join misfolding misfoldome pathophysiologic placentas preeclampsia prefibrillar presenilin proteoforms protofibrils prototype secretases shares supramolecular
Tagcloud (Intersection) ?