KLK5 and MANBAL

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KLK5	MANBAL
Description		kallikrein related peptidase 5	mannosidase beta like
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Secretory Granule Epidermal Lamellar Body	Membrane
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	Protein Binding
	Biological Process	Positive Regulation Of Antibacterial Peptide Production Proteolysis Epidermis Development Extracellular Matrix Disassembly Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Protein Maturation Cornification Amelogenesis
Pathways		Formation of the cornified envelope Formation of the cornified envelope Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
Drugs
Diseases
GWAS			Appendicular lean mass ( 33097823)
Interacting Genes		12 interacting genes: AURKA BAG4 CASP8 DSG1 ERBB2 ESR1 IGF1R MANBAL NOTCH2 SERPINA1 TGFB1 TSG101	21 interacting genes: ATP13A1 CACNA1A CATSPERH CMTM2 GPR151 KLK5 MALL MARCHF5 MPDU1 NIPAL3 OTOP2 PIGF SCRG1 SLC39A9 STX3 TMBIM6 TMEM115 TMEM203 UBQLN1 VKORC1 VTI1B
Entrez ID		25818	63905
HPRD ID		05732	14356
Ensembl ID		ENSG00000167754	ENSG00000101363
Uniprot IDs		Q9Y337	A2A2E0 Q9NQG1
PDB IDs		2PSX 2PSY 6QFE 7U5B
Enriched GO Terms of Interacting Partners?		Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Positive Regulation Of Myeloid Leukocyte Differentiation Negative Regulation Of Apoptotic Process Response To Wounding Regulation Of MiRNA Transcription Regulation Of Signal Transduction Regulation Of MiRNA Metabolic Process Positive Regulation Of Macrophage Differentiation Response To Estradiol Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Ubiquitin Protein Ligase Binding Positive Regulation Of Myeloid Cell Differentiation Regulation Of Signaling Plasma Membrane Branch Elongation Of An Epithelium Liver Development Positive Regulation Of Fibroblast Migration Axis Elongation Protein-containing Complex Binding Branching Involved In Mammary Gland Duct Morphogenesis Regulation Of Myeloid Leukocyte Differentiation Developmental Growth Developmental Growth Involved In Morphogenesis Myeloid Dendritic Cell Differentiation Positive Regulation Of Smooth Muscle Cell Differentiation Myeloid Leukocyte Differentiation Regulation Of Macrophage Differentiation Positive Regulation Of Cell Development Regulation Of Cell Development Regulation Of Hemopoiesis Animal Organ Development Negative Regulation Of MiRNA Transcription Myeloid Dendritic Cell Activation Gland Morphogenesis Liver Regeneration Lymphocyte Activation Positive Regulation Of MAPK Cascade Plasma Membrane Bounded Cell Projection Organization Maternal Process Involved In Female Pregnancy Epithelial Cell Proliferation Positive Regulation Of Cell Population Proliferation Response To Progesterone Positive Regulation Of Leukocyte Differentiation Receptor Complex Positive Regulation Of Epithelial Cell Proliferation Dendritic Cell Differentiation	Membrane Endoplasmic Reticulum Membrane Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Inorganic Ion Transmembrane Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Transmembrane Transport Monoatomic Ion Transport Metal Ion Transport Endoplasmic Reticulum SNARE Complex Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane SNAP Receptor Activity Intracellular Calcium Ion Homeostasis Endoribonuclease Inhibitor Activity Intracellular Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Negative Regulation Of Calcium Ion Transport Calcium Ion Homeostasis Negative Regulation Of Calcium Ion Transmembrane Transport Intracellular Monoatomic Cation Homeostasis Inorganic Ion Homeostasis Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Autophagosome Maturation Presynaptic Endosome Membrane Negative Regulation Of Store-operated Calcium Channel Activity Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Cellular Response To Testosterone Stimulus Zinc Efflux Transmembrane Transporter Activity Extraction Of Mislocalized Protein From ER Membrane ABC-type Manganese Transporter Activity Membrane Protein Dislocase Activity Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Vesicle Docking Monoatomic Ion Homeostasis SNARE Binding Negative Regulation Of Cation Transmembrane Transport Chemical Homeostasis Ethanolaminephosphotransferase Activity Intracellular Chemical Homeostasis Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Toll-like Receptor 3 Signaling Pathway P-type Transmembrane Transporter Activity
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