KLK5 and BAG4

Number of citations of the paper that reports this interaction (PubMedID 25640309)
0

Data Source:
BioGRID (two hybrid)

		KLK5	BAG4
Description		kallikrein related peptidase 5	BAG cochaperone 4
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Secretory Granule Epidermal Lamellar Body	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	Adenyl-nucleotide Exchange Factor Activity RNA Binding Protein Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding Protein-folding Chaperone Binding
	Biological Process	Positive Regulation Of Antibacterial Peptide Production Proteolysis Epidermis Development Extracellular Matrix Disassembly Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Protein Maturation Cornification Amelogenesis	Protein Folding Positive Regulation Of Fibroblast Migration Positive Regulation Of Actin Filament Polymerization Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Adhesion Protein Stabilization Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus Protein Localization To Plasma Membrane Negative Regulation Of MRNA Modification Ruffle Assembly Negative Regulation Of Protein Targeting To Mitochondrion
Pathways		Formation of the cornified envelope Formation of the cornified envelope Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	Regulation of HSF1-mediated heat shock response Signaling by FGFR1 in disease TNF signaling Signaling by plasma membrane FGFR1 fusions
Drugs
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Schizophrenia ( 28991256 29483656)
Interacting Genes		12 interacting genes: AURKA BAG4 CASP8 DSG1 ERBB2 ESR1 IGF1R MANBAL NOTCH2 SERPINA1 TGFB1 TSG101	141 interacting genes: ABI2 ACOT7 ADAMTSL4 ALG13 ANKHD1 APOBEC1 ARID5A ATAD2 ATOSB ATP23 BAP1 BCAS3 BCL2 BCL6B BEX1 BLZF1 BMS1 C3orf38 CASP2 CASZ1 CBFA2T2 CCL5 CEP55 CIMAP1C CPSF7 DDIT4L DIRAS3 DMRTB1 DZIP3 EFEMP1 EIF4ENIF1 EPSTI1 ERRFI1 FAM222B FARS2 FTH1 FYN GLCE GPANK1 GPS2 GRAP2 GRIP1 HOXA1 HSPA1A HSPA1B HSPA1L HSPA2 HSPA6 HSPA8 IL13RA2 IL24 IST1 ITIH5 KCTD6 KCTD7 KIF5B KLK5 KLK7 KLK9 KRT31 KRTAP13-1 KRTAP13-4 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP6-3 LASP1 LRATD2 LYPD3 MAGED1 MEI4 MRC2 MTA3 MYOZ1 MYOZ3 MYPOP NAT2 ODF1 P4HA3 PDCD6 PDLIM2 PEF1 PGRMC2 PHF19 PKP2 PLAC8 PPIL6 PRDM14 PRPF6 PRRC2B PSMB5 PYCR3 QKI RAMAC RASL10B RBFOX2 RBM22 RBM42 RBM7 RBPMS RHOBTB2 RNF20 RPL22 RUNX1 SAMD4A SAXO1 SAXO4 SCGB3A1 SF1 SF3B4 SH3RF2 SIAH1 SNRPA SNRPB SNRPC SNRPN SNW1 SS18L1 SUOX TBC1D3B TBC1D3G TBC1D7 TCL1B TEKT5 TFAP2D TFIP11 THRSP TINAGL1 TLE5 TNFRSF1A TNFRSF25 TRAPPC6A TSG101 UNKL USP22 VIM VPS37C ZBTB45 ZBTB5 ZIM2
Entrez ID		25818	9530
HPRD ID		05732	04861
Ensembl ID		ENSG00000167754	ENSG00000156735
Uniprot IDs		Q9Y337	O95429
PDB IDs		2PSX 2PSY 6QFE 7U5B	1M62 1M7K
Enriched GO Terms of Interacting Partners?		Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Positive Regulation Of Myeloid Leukocyte Differentiation Negative Regulation Of Apoptotic Process Response To Wounding Regulation Of MiRNA Transcription Regulation Of Signal Transduction Regulation Of MiRNA Metabolic Process Positive Regulation Of Macrophage Differentiation Response To Estradiol Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Ubiquitin Protein Ligase Binding Positive Regulation Of Myeloid Cell Differentiation Regulation Of Signaling Plasma Membrane Branch Elongation Of An Epithelium Liver Development Positive Regulation Of Fibroblast Migration Axis Elongation Protein-containing Complex Binding Branching Involved In Mammary Gland Duct Morphogenesis Regulation Of Myeloid Leukocyte Differentiation Developmental Growth Developmental Growth Involved In Morphogenesis Myeloid Dendritic Cell Differentiation Positive Regulation Of Smooth Muscle Cell Differentiation Myeloid Leukocyte Differentiation Regulation Of Macrophage Differentiation Positive Regulation Of Cell Development Regulation Of Cell Development Regulation Of Hemopoiesis Animal Organ Development Negative Regulation Of MiRNA Transcription Myeloid Dendritic Cell Activation Gland Morphogenesis Liver Regeneration Lymphocyte Activation Positive Regulation Of MAPK Cascade Plasma Membrane Bounded Cell Projection Organization Maternal Process Involved In Female Pregnancy Epithelial Cell Proliferation Positive Regulation Of Cell Population Proliferation Response To Progesterone Positive Regulation Of Leukocyte Differentiation Receptor Complex Positive Regulation Of Epithelial Cell Proliferation Dendritic Cell Differentiation	MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Spliceosomal Complex Protein Refolding MRNA Metabolic Process MRNA Processing ATP-dependent Protein Folding Chaperone Intermediate Filament RNA Binding RNA Splicing Protein Binding Hair Cycle C3HC4-type RING Finger Domain Binding Transcription Corepressor Activity ATP-dependent Protein Disaggregase Activity Protein Folding Chaperone Cellular Heat Acclimation Nucleus Heat Shock Protein Binding U1 SnRNP U4/U6 X U5 Tri-snRNP Complex Regulation Of RNA Splicing RNA Processing RNA Metabolic Process Negative Regulation Of Protein Ubiquitination Regulation Of Protein Ubiquitination Catalytic Step 2 Spliceosome Regulation Of MRNA Metabolic Process Identical Protein Binding Negative Regulation Of Post-translational Protein Modification Negative Regulation Of Inclusion Body Assembly Keratin Filament Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Post-translational Protein Modification SnRNP Binding Negative Regulation Of RNA Metabolic Process Ubiquitin Protein Ligase Binding MRNA Binding Response To Temperature Stimulus Nucleic Acid Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome U2-type Prespliceosome Unfolded Protein Binding Positive Regulation Of Antibacterial Peptide Production Epidermal Lamellar Body Macromolecule Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Calcium-dependent Protein Binding Blood Microparticle
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