KLK5 and DSG1

Number of citations of the paper that reports this interaction (PMID 15140227)
59

Data Source:
HPRD (in vitro)

		KLK5	DSG1
Gene Name		kallikrein-related peptidase 5	desmoglein 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Epidermal Lamellar Body	Cytosol Plasma Membrane Cell-cell Junction Cytoplasmic Side Of Plasma Membrane Integral Component Of Membrane Apical Plasma Membrane Lateral Plasma Membrane Desmosome Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity	Calcium Ion Binding Toxic Substance Binding Gamma-catenin Binding
	Biological Process	Proteolysis Epidermis Development Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway	Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell-cell Junction Assembly Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Single Organismal Cell-cell Adhesion Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Response To Progesterone Protein Stabilization Maternal Process Involved In Female Pregnancy
Pathways			Apoptotic cleavage of cell adhesion proteins Apoptotic cleavage of cellular proteins Programmed Cell Death Apoptotic execution phase
Drugs
Diseases
GWAS			Eosinophilic esophagitis (pediatric) ( 20208534)
Protein-Protein Interactions		2 interactors: DSG1 SERPINA1	7 interactors: DSC1 DSC2 JUP KLK5 PKP1 PKP2 PKP3
Entrez ID		25818	1828
HPRD ID		05732	00515
Ensembl ID		ENSG00000167754	ENSG00000134760
Uniprot IDs		Q9Y337	Q02413
PDB IDs		2PSX 2PSY
Enriched GO Terms of Interacting Partners?		Response To Methanol Response To Triglyceride Response To Chromate Response To Steroid Hormone Negative Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Serine-type Peptidase Activity Response To Lipid Response To Organic Cyclic Compound Response To Hormone Response To Lead Ion Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Acute-phase Response Response To Progesterone Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Platelet Degranulation Execution Phase Of Apoptosis Acute Inflammatory Response Maternal Process Involved In Female Pregnancy Protein Stabilization Cell-cell Junction Assembly Response To Estradiol Response To Organic Substance Regulation Of Protein Stability	Desmosome Assembly Bundle Of His Cell To Purkinje Myocyte Communication Desmosome Organization Ventricular Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Cardiac Muscle Cell Action Potential Involved In Contraction Single Organismal Cell-cell Adhesion Cell Adhesion Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Contraction Cardiac Conduction Intermediate Filament Bundle Assembly Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Regulation Of Striated Muscle Contraction Action Potential Cell-cell Junction Assembly Regulation Of Muscle Contraction Regulation Of Heart Contraction Intermediate Filament Organization Cell Junction Assembly Cell-cell Junction Organization Regulation Of Membrane Potential Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Regulation Of Actin Filament-based Process Establishment Of Protein Localization To Plasma Membrane Adherens Junction Organization Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Regulation Of Cellular Component Movement Protein Localization To Plasma Membrane Endothelial Cell-cell Adhesion Adherens Junction Maintenance Cellular Component Assembly Cellular Response To Indole-3-methanol Maintenance Of Organ Identity Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Plasma Membrane Organization Establishment Of Protein Localization To Membrane Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Regulation Of Tight Junction Assembly Cytoskeletal Anchoring At Plasma Membrane Cytoskeleton Organization Cell Communication By Electrical Coupling Involved In Cardiac Conduction Cell Communication By Electrical Coupling Cell-cell Signaling Involved In Cardiac Conduction Protein Localization To Membrane Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Cell Fate Specification
Tagcloud ?		bag1 bcl2l2 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 map2k7 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 serpinb5 serpine1 thbs1 thbs2	cadherins companion continuity desmocollin desmoglein desmoplakin desmosomal desmosomes displaying dsc1 dsc2 dsc3 dsg2 dsg3 exclusive follicle hair immunopositive mutually ontogenic outer plakoglobin plakophilin practically rood root sheath subinfundibular trichocytes
Tagcloud (Difference) ?		bag1 bcl2l2 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 map2k7 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 serpinb5 serpine1 thbs1 thbs2	cadherins companion continuity desmocollin desmoglein desmoplakin desmosomal desmosomes displaying dsc1 dsc2 dsc3 dsg2 dsg3 exclusive follicle hair immunopositive mutually ontogenic outer plakoglobin plakophilin practically rood root sheath subinfundibular trichocytes
Tagcloud (Intersection) ?