NUTM1 and ARHGEF6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NUTM1	ARHGEF6
Description		NUT midline carcinoma family member 1	Rac/Cdc42 guanine nucleotide exchange factor 6
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GO Annotations	Cellular Component	Nucleus Cytoplasm	Cytoplasm Cytosol Cell-cell Junction Lamellipodium Cell Projection
	Molecular Function	Protein Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding
	Biological Process		Apoptotic Process JNK Cascade Lamellipodium Assembly
Pathways			NRAGE signals death through JNK G alpha (12/13) signalling events Regulation of cytoskeletal remodeling and cell spreading by IPP complex components G beta:gamma signalling through CDC42 CDC42 GTPase cycle RAC1 GTPase cycle RHOU GTPase cycle
Drugs
Diseases			Non-syndromic X-linked mental retardation
GWAS			Autism spectrum disorder ( 34069769) Breast cancer ( 29059683)
Interacting Genes		54 interacting genes: ALOX5 AQP1 ARHGEF6 AXIN1 CATSPERT CCDC116 CCDC185 CCHCR1 CDC20B CDK18 CHCHD3 ENKD1 FAM161A GADD45GIP1 GPANK1 HSPBAP1 IFIT2 KANK2 KANSL1 KPNA2 LHX8 LMO1 LMO2 LMO3 LRRC8E MBD3 METTL17 MORN4 MTCL2 NEBL OSTF1 P4HA3 PLEKHF2 PRKAA2 PRKAB2 PRPF18 PSME4 RCOR3 RIC8A SAMD4A SAMD4B SCNM1 SH2D1B SH2D4A SMARCD1 TBC1D21 TEAD4 TLE5 TP53BP2 TSGA10IP TTC23 TXN2 ZMYND10 ZNF277	36 interacting genes: ADAM15 ARAP3 ARHGEF7 BMPR1B CAPNS1 CBFA2T3 CCDC33 CDC42 EPHB2 GIT1 GOLGA2 GPRASP2 HSF2BP KRT27 NUTM1 PAK1 PAK2 PAK3 PARVB PNMA1 POU6F2 RWDD2A SH2D1A SH3GL3 SIRPA SMAD1 SMAD2 SMAD3 TGFBR1 TGFBR2 TMEM108 TP53BP2 TRAF2 TRIM54 YWHAG ZNF580
Entrez ID		256646	9459
HPRD ID		10606	02226
Ensembl ID		ENSG00000184507	ENSG00000129675
Uniprot IDs		A0AAG2UVG0 A0AAG2UVR5 A0AAG2UXE6 Q86Y26	B7Z3C7 Q15052 Q8N4Q3
PDB IDs		7XEZ 7XFG	1UJY 1WYR
Enriched GO Terms of Interacting Partners?		Protein Binding	Enzyme-linked Receptor Protein Signaling Pathway Response To Growth Factor Dendritic Spine Development I-SMAD Binding Cellular Response To Growth Factor Stimulus Regulation Of Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Ephrin Receptor Signaling Pathway SMAD Protein Signal Transduction SMAD Protein Complex Trophoblast Cell Migration Heteromeric SMAD Protein Complex Embryonic Cranial Skeleton Morphogenesis Activin Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Activity Regulation Of Stress Fiber Assembly Co-SMAD Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Primary MiRNA Processing Transforming Growth Factor Beta Receptor Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway SMAD Binding Protein Kinase Binding Homomeric SMAD Protein Complex Positive Regulation Of Stress Fiber Assembly Regulation Of Actin Cytoskeleton Organization Dendritic Spine Morphogenesis Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Microtubule Nucleation Protein Kinase Activity Positive Regulation Of Actin Filament Bundle Assembly Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Paraxial Mesoderm Morphogenesis Transforming Growth Factor Beta Ligand-receptor Complex Regulation Of Actin Filament-based Process Response To Transforming Growth Factor Beta Immune System Process Regulation Of Cartilage Development Protein Serine/threonine Kinase Activity Regulation Of Cellular Component Organization Positive Regulation Of Cell Migration Regulation Of Actin Filament Organization Response To Cholesterol Roof Of Mouth Development Response To Stress Positive Regulation Of Cell Motility Regulation Of Organelle Organization Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
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