CCR8 and ATP2A1

Number of citations: 90 (PubMedID 28298427)
Data Source: BioGRID (two hybrid)

		CCR8	ATP2A1
Name		C-C motif chemokine receptor 8	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
Structure			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Sarcoplasmic Reticulum Platelet Dense Tubular Network Membrane H Zone I Band Sarcoplasmic Reticulum Membrane Calcium Channel Complex Perinuclear Region Of Cytoplasm
	Molecular Function	G Protein-coupled Receptor Activity Chemokine Receptor Activity Coreceptor Activity C-C Chemokine Receptor Activity C-C Chemokine Binding	Nucleotide Binding P-type Calcium Transporter Activity Calcium Ion Binding Protein Binding ATP Binding ATP Hydrolysis Activity Calcium-dependent ATPase Activity Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Chemotaxis Immune Response Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus	Monoatomic Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Regulation Of Striated Muscle Contraction Apoptotic Mitochondrial Changes Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Monoatomic Ion Transmembrane Transport Response To Endoplasmic Reticulum Stress Negative Regulation Of Striated Muscle Contraction Positive Regulation Of Mitochondrial Calcium Ion Concentration Maintenance Of Mitochondrion Location Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Calcium Ion Import Calcium Ion Transmembrane Transport Relaxation Of Skeletal Muscle Positive Regulation Of Cardiac Muscle Cell Contraction Positive Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Positive Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Regulation Of Cardiac Conduction Calcium Ion Import Into Sarcoplasmic Reticulum
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events	Pre-NOTCH Processing in Golgi Reduction of cytosolic Ca++ levels Ion homeostasis Ion transport by P-type ATPases
Drugs		None	Enflurane Ritodrine Desflurane Sevoflurane Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate Tetrafluoroaluminate Ion 2,5-di-tert-butylhydroquinone (6AR,11AS,11BR)-10-ACETYL-9-HYDROXY-7,7-DIMETHYL-2,6,6A,7,11A,11B-HEXAHYDRO-11H-PYRROLO[1',2':2,3]ISOINDOLO[4,5,6-CD]INDOL-11-ONE
Diseases		None	Brody myopathy
GWAS		Daytime sleep phenotypes ( 27126917 ) Medication use (thyroid preparations) ( 31015401 )	BMI (adjusted for smoking behaviour) ( 28443625 ) BMI in non-smokers ( 28443625 ) Body fat distribution (arm fat ratio) ( 30664634 ) Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Body mass index ( 25673413 26961502 28892062 19079260 ) Body mass index (joint analysis main effects and smoking interaction) ( 28443625 ) Brain morphology (MOSTest) ( 32665545 ) Cannabis use ( 30150663 ) Crohn's disease ( 28067908 ) Extremely high intelligence ( 29520040 ) Hip circumference ( 31453325 25673412 ) Hip circumference variance ( 31453325 ) Inflammatory bowel disease ( 28067908 ) Intelligence ( 28530673 ) Intelligence (MTAG) ( 29326435 ) Lamb consumption ( 32066663 ) Type 2 diabetes ( 30297969 ) Waist circumference ( 31453325 ) Waist circumference variance ( 31453325 ) Weight ( 19079260 )
Interacting Genes		19 interacting genes: ATP2A1 CCL1 CCL16 CCL17 CCL4 EI24 ERGIC3 GABBR1 GABRD NAGPA PAQR6 PLEKHB1 RTN3 SPNS1 SPP1 THY1 TPST1 TPST2 UCKL1	8 interacting genes: APPL1 CCR8 IRS1 IRS2 PLN RNF167 SLN TULP3
Entrez ID		1237	487
HPRD ID		03497	00157
Ensembl ID		ENSG00000179934	ENSG00000196296
Uniprot IDs		P51685	O14983
PDB IDs		8KFX 8KFY 8KFZ 8TLM 8U1U 8XML	Not available
GO Terms Enriched among Interactors		Chemokine Activity Eosinophil Migration Eosinophil Chemotaxis Protein-tyrosine Sulfotransferase Activity Cytokine Activity CCR Chemokine Receptor Binding Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Cell-cell Signaling Signaling Cell Communication Axolemma Cell Chemotaxis Chemokine-mediated Signaling Pathway Granulocyte Chemotaxis Negative Regulation Of Neuron Projection Regeneration 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Granulocyte Migration Positive Regulation Of Calcium Ion Transport Humoral Immune Response Positive Regulation Of Transport Golgi Apparatus Gamma-aminobutyric Acid Signaling Pathway Myeloid Leukocyte Migration Chemotaxis Leukocyte Chemotaxis Regulation Of Neuron Projection Regeneration Locomotion Positive Regulation Of Leukocyte Migration Synaptic Transmission, GABAergic Extracellular Space Maintenance Of Mitochondrion Location Regulation Of Transport Positive Regulation Of Monoatomic Ion Transport Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Peptidyl-tyrosine Sulfation N-acetylglucosamine-1-phosphodiester Alpha-N-acetylglucosaminidase Activity Calcium-dependent ATPase Activity Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Signal Transduction Relaxation Of Skeletal Muscle H Zone Regulation Of Calcium Ion Transport Positive Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Positive Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Positive Regulation Of Cardiac Muscle Cell Contraction G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential G Protein-coupled GABA Receptor Activity G Protein-coupled Receptor Dimeric Complex	Negative Regulation Of Transport Positive Regulation Of D-glucose Import Negative Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Positive Regulation Of D-glucose Transmembrane Transport Regulation Of D-glucose Import Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Regulation Of D-glucose Transmembrane Transport Insulin Receptor Signaling Pathway Positive Regulation Of Fatty Acid Beta-oxidation Negative Regulation Of ATP-dependent Activity Positive Regulation Of Fatty Acid Oxidation Negative Regulation Of Calcium Ion Import Negative Regulation Of Transmembrane Transport Regulation Of Fatty Acid Beta-oxidation Phosphatidylinositol 3-kinase Binding Positive Regulation Of Glycogen Biosynthetic Process Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Regulation Of Relaxation Of Muscle Insulin Receptor Binding Response To Insulin Cell Surface Receptor Signaling Pathway Positive Regulation Of Lipid Catabolic Process Negative Regulation Of Transporter Activity Regulation Of Glycogen Biosynthetic Process Regulation Of Fatty Acid Oxidation Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of ATP-dependent Activity Positive Regulation Of Fatty Acid Metabolic Process Sarcoplasmic Reticulum Membrane Negative Regulation Of Calcium Ion Transmembrane Transport Regulation Of Glycogen Metabolic Process Regulation Of Calcium Ion Import Positive Regulation Of Glucose Metabolic Process Negative Regulation Of Calcium Ion Transport Regulation Of Transport Response To Peptide Hormone Negative Regulation Of Intracellular Transport Regulation Of Lipid Catabolic Process Enzyme Inhibitor Activity Sarcoplasmic Reticulum Negative Regulation Of Cation Transmembrane Transport Circadian Sleep/wake Cycle, Sleep Phospholamban Complex Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Monoatomic Ion Transmembrane Transport Signaling Adaptor Activity Regulation Of Monoatomic Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity