CCR8 and TPST1

Number of citations: 0 (PubMedID 17558413)
Data Source: HPRD (in vitro)

		CCR8	TPST1
Name		C-C motif chemokine receptor 8	tyrosylprotein sulfotransferase 1
Structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane	Golgi Membrane Golgi Apparatus Golgi Lumen Trans-Golgi Network Membrane
	Molecular Function	G Protein-coupled Receptor Activity Chemokine Receptor Activity Coreceptor Activity C-C Chemokine Receptor Activity C-C Chemokine Binding	Protein-tyrosine Sulfotransferase Activity Transferase Activity Protein Homodimerization Activity
	Biological Process	Chemotaxis Immune Response Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus	Post-translational Protein Modification 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events	Cytosolic sulfonation of small molecules Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation Defective F8 sulfation at Y1699
GWAS		Daytime sleep phenotypes ( 27126917 ) Medication use (thyroid preparations) ( 31015401 )	Blood protein levels ( 30072576 ) Gout ( 22179738 )
Interacting Genes		19 interacting genes: ATP2A1 CCL1 CCL16 CCL17 CCL4 EI24 ERGIC3 GABBR1 GABRD NAGPA PAQR6 PLEKHB1 RTN3 SPNS1 SPP1 THY1 TPST1 TPST2 UCKL1	9 interacting genes: CCR1 CCR8 CMKLR1 CMKLR2 GOLPH3 GOLPH3L GP1BA SELPLG TMEM132D
Entrez ID		1237	8460
HPRD ID		03497	07216
Ensembl ID		ENSG00000179934	ENSG00000169902
Uniprot IDs		P51685	O60507
PDB IDs		8KFX 8KFY 8KFZ 8TLM 8U1U 8XML	5WRI 5WRJ
GO Terms Enriched among Interactors		Chemokine Activity Eosinophil Migration Eosinophil Chemotaxis Protein-tyrosine Sulfotransferase Activity Cytokine Activity CCR Chemokine Receptor Binding Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Cell-cell Signaling Signaling Cell Communication Axolemma Cell Chemotaxis Chemokine-mediated Signaling Pathway Granulocyte Chemotaxis Negative Regulation Of Neuron Projection Regeneration 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Granulocyte Migration Positive Regulation Of Calcium Ion Transport Humoral Immune Response Positive Regulation Of Transport Golgi Apparatus Gamma-aminobutyric Acid Signaling Pathway Myeloid Leukocyte Migration Chemotaxis Leukocyte Chemotaxis Regulation Of Neuron Projection Regeneration Locomotion Positive Regulation Of Leukocyte Migration Synaptic Transmission, GABAergic Extracellular Space Maintenance Of Mitochondrion Location Regulation Of Transport Positive Regulation Of Monoatomic Ion Transport Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Peptidyl-tyrosine Sulfation N-acetylglucosamine-1-phosphodiester Alpha-N-acetylglucosaminidase Activity Calcium-dependent ATPase Activity Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Signal Transduction Relaxation Of Skeletal Muscle H Zone Regulation Of Calcium Ion Transport Positive Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Positive Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Positive Regulation Of Cardiac Muscle Cell Contraction G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential G Protein-coupled GABA Receptor Activity G Protein-coupled Receptor Dimeric Complex	Chemokine Receptor Activity Adipokinetic Hormone Binding Adipokinetic Hormone Receptor Activity Golgi Vesicle Budding Cargo Adaptor Activity Protein Targeting To Golgi Apparatus Chemokine-mediated Signaling Pathway Golgi Cisterna G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Cell Adhesion Positive Regulation Of Cytosolic Calcium Ion Concentration C-C Chemokine Binding C-C Chemokine Receptor Activity Leukocyte Tethering Or Rolling Leukocyte Adhesion To Vascular Endothelial Cell Phosphatidylinositol-4-phosphate Binding Vesicle Budding From Membrane Golgi To Plasma Membrane Protein Transport Membrane Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Leukocyte Cell-cell Adhesion Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Chemotaxis Golgi Cisterna Membrane External Side Of Plasma Membrane Locomotion Cell Migration Positive Regulation Of Mononuclear Cell Migration Cytokine-mediated Signaling Pathway Chemokine (C-C Motif) Ligand 5 Binding Positive Regulation Of Leukocyte Chemotaxis Chemokine (C-C Motif) Ligand 7 Binding Cellular Response To Cytokine Stimulus Leukocyte Adhesive Activation Asymmetric Golgi Ribbon Formation Post-Golgi Vesicle-mediated Transport Cell Motility Cell Adhesion Molecule Production Cellular Response To Rapamycin Golgi Organization Plasma Membrane Protein Retention In Golgi Apparatus Vesicle-mediated Transport To The Plasma Membrane Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Response To Peptide Positive Regulation Of Chemotaxis Response To Cytokine