CCR8 and CCL1

Number of citations of the paper that reports this interaction (PubMedID 12967681)
0

Data Source:
HPRD (in vivo, in vitro)

		CCR8	CCL1
Description		C-C motif chemokine receptor 8	C-C motif chemokine ligand 1
Image
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane	Extracellular Region Extracellular Space
	Molecular Function	G Protein-coupled Receptor Activity Chemokine Receptor Activity Coreceptor Activity C-C Chemokine Receptor Activity C-C Chemokine Binding	Cytokine Activity Chemokine Activity CCR Chemokine Receptor Binding
	Biological Process	Chemotaxis Immune Response Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus	Intracellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Immune Response Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Viral Process Positive Regulation Of Cell Migration Killing Of Cells Of Another Organism Positive Regulation Of Interleukin-17 Production Eosinophil Chemotaxis Positive Regulation Of Inflammatory Response Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Positive Regulation Of Monocyte Chemotaxis
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs
Diseases
GWAS		Daytime sleep phenotypes ( 27126917) Medication use (thyroid preparations) ( 31015401)	Crohn's disease ( 22412388)
Interacting Genes		19 interacting genes: ATP2A1 CCL1 CCL16 CCL17 CCL4 EI24 ERGIC3 GABBR1 GABRD NAGPA PAQR6 PLEKHB1 RTN3 SPNS1 SPP1 THY1 TPST1 TPST2 UCKL1	3 interacting genes: CCR8 CXCL11 HUWE1
Entrez ID		1237	6346
HPRD ID		03497	01654
Ensembl ID		ENSG00000179934	ENSG00000108702
Uniprot IDs		P51685	P22362
PDB IDs		8KFX 8KFY 8KFZ 8TLM 8U1U 8XML	1EL0 4OIJ 4OIK 8U1U
Enriched GO Terms of Interacting Partners?		Chemokine Activity Eosinophil Migration Eosinophil Chemotaxis Protein-tyrosine Sulfotransferase Activity Cytokine Activity CCR Chemokine Receptor Binding Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Cell-cell Signaling Signaling Cell Communication Axolemma Cell Chemotaxis Chemokine-mediated Signaling Pathway Granulocyte Chemotaxis Negative Regulation Of Neuron Projection Regeneration 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Granulocyte Migration Positive Regulation Of Calcium Ion Transport Humoral Immune Response Positive Regulation Of Transport Golgi Apparatus Gamma-aminobutyric Acid Signaling Pathway Myeloid Leukocyte Migration Chemotaxis Leukocyte Chemotaxis Regulation Of Neuron Projection Regeneration Locomotion Positive Regulation Of Leukocyte Migration Synaptic Transmission, GABAergic Extracellular Space Maintenance Of Mitochondrion Location Regulation Of Transport Positive Regulation Of Monoatomic Ion Transport Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Peptidyl-tyrosine Sulfation N-acetylglucosamine-1-phosphodiester Alpha-N-acetylglucosaminidase Activity Calcium-dependent ATPase Activity Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Signal Transduction Relaxation Of Skeletal Muscle H Zone Regulation Of Calcium Ion Transport Positive Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Positive Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Positive Regulation Of Cardiac Muscle Cell Contraction G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential G Protein-coupled GABA Receptor Activity G Protein-coupled Receptor Dimeric Complex	Chemokine-mediated Signaling Pathway Locomotion Cell Chemotaxis Chemotaxis CXCR3 Chemokine Receptor Binding Histone Ubiquitin Ligase Activity Negative Regulation Of Mitochondrial Fusion Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Mitochondrial Fusion Peroxisome Proliferator Activated Receptor Signaling Pathway Positive Regulation Of Type 2 Mitophagy T Cell Chemotaxis Ubiquitin-ubiquitin Ligase Activity Chemokine Receptor Activity C-C Chemokine Binding C-C Chemokine Receptor Activity Lymphocyte Chemotaxis Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Positive Regulation Of Mitophagy Protein Branched Polyubiquitination Positive Regulation Of Autophagy Of Mitochondrion
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