CCR8 and GABRD

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		CCR8	GABRD
Description		C-C motif chemokine receptor 8	gamma-aminobutyric acid type A receptor subunit delta
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane	Plasma Membrane Membrane Axon Dendrite Chloride Channel Complex Neuronal Cell Body Postsynaptic Membrane Glutamatergic Synapse GABA-ergic Synapse GABA-A Receptor Complex
	Molecular Function	G Protein-coupled Receptor Activity Chemokine Receptor Activity Coreceptor Activity C-C Chemokine Receptor Activity C-C Chemokine Binding	Transmembrane Signaling Receptor Activity GABA-A Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Chloride Channel Activity Protein Binding Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Chemotaxis Immune Response Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus	Monoatomic Ion Transport Chloride Transport Signal Transduction Gamma-aminobutyric Acid Signaling Pathway Cell-cell Signaling Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport Synaptic Transmission, GABAergic Regulation Of Postsynaptic Membrane Potential Chloride Transmembrane Transport
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs			Lorazepam Ethchlorvynol Enflurane Temazepam Butabarbital Butalbital Phenytoin Etomidate Talbutal Pentobarbital Clobazam Meprobamate Eszopiclone Alprazolam Metharbital Chlordiazepoxide Amoxapine Adinazolam Lamotrigine Medroxyprogesterone acetate Clorazepic acid Midazolam Flurazepam Isoflurane Primidone Halazepam Propofol Diazepam Oxazepam Triazolam Ethanol Methoxyflurane Memantine Clonazepam Methyprylon Halothane Desflurane Flumazenil Estazolam Sevoflurane Glutethimide Camazepam Delorazepam Flunitrazepam Ethyl loflazepate Cloxazolam Bromazepam Clotiazepam Fludiazepam Ketazolam Prazepam Quazepam Cinolazepam Nitrazepam Prasterone Taurine Ganaxolone Brotizolam Stiripentol Etizolam Thiocolchicoside Brexanolone Apalutamide Remimazolam 1,2-Benzodiazepine Pinazepam Medazepam Loprazolam Doxefazepam Lormetazepam Nordazepam Oxazepam acetate Cinazepam Bentazepam Mexazolam
Diseases			Febrile seizures, including: Febrile convulsions; Generalized epilepsy with febrile seizure plus (GEFS+); Dravet syndrome/ Severe myoclonic epilepsy in infancy (SMEI)
GWAS		Daytime sleep phenotypes ( 27126917) Medication use (thyroid preparations) ( 31015401)	Body mass index ( 26426971)
Interacting Genes		19 interacting genes: ATP2A1 CCL1 CCL16 CCL17 CCL4 EI24 ERGIC3 GABBR1 GABRD NAGPA PAQR6 PLEKHB1 RTN3 SPNS1 SPP1 THY1 TPST1 TPST2 UCKL1	6 interacting genes: CCR8 ETS2 MDFI NOTCH2NLA UBQLN1 UBQLN4
Entrez ID		1237	2563
HPRD ID		03497	08842
Ensembl ID		ENSG00000179934	ENSG00000187730
Uniprot IDs		P51685	A8K496 O14764
PDB IDs		8KFX 8KFY 8KFZ 8TLM 8U1U 8XML	7QN5 7QN6 7QN7 7QN8 7QN9 7QNC 7QND
Enriched GO Terms of Interacting Partners?		Chemokine Activity Eosinophil Migration Eosinophil Chemotaxis Protein-tyrosine Sulfotransferase Activity Cytokine Activity CCR Chemokine Receptor Binding Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Cell-cell Signaling Signaling Cell Communication Axolemma Cell Chemotaxis Chemokine-mediated Signaling Pathway Granulocyte Chemotaxis Negative Regulation Of Neuron Projection Regeneration 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Granulocyte Migration Positive Regulation Of Calcium Ion Transport Humoral Immune Response Positive Regulation Of Transport Golgi Apparatus Gamma-aminobutyric Acid Signaling Pathway Myeloid Leukocyte Migration Chemotaxis Leukocyte Chemotaxis Regulation Of Neuron Projection Regeneration Locomotion Positive Regulation Of Leukocyte Migration Synaptic Transmission, GABAergic Extracellular Space Maintenance Of Mitochondrion Location Regulation Of Transport Positive Regulation Of Monoatomic Ion Transport Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Peptidyl-tyrosine Sulfation N-acetylglucosamine-1-phosphodiester Alpha-N-acetylglucosaminidase Activity Calcium-dependent ATPase Activity Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Signal Transduction Relaxation Of Skeletal Muscle H Zone Regulation Of Calcium Ion Transport Positive Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Positive Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Positive Regulation Of Cardiac Muscle Cell Contraction G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential G Protein-coupled GABA Receptor Activity G Protein-coupled Receptor Dimeric Complex	Polyubiquitin Modification-dependent Protein Binding Negative Regulation Of Store-operated Calcium Channel Activity Autophagosome Ectodermal Cell Fate Commitment Nuclear Proteasome Complex Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Autophagosome Maturation
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