CCR8 and PLEKHB1

Number of citations: 90 (PubMedID 28298427)
Data Source: BioGRID (two hybrid)

		CCR8	PLEKHB1
Name		C-C motif chemokine receptor 8	pleckstrin homology domain containing B1
Structure			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane	Cytoplasm Membrane
	Molecular Function	G Protein-coupled Receptor Activity Chemokine Receptor Activity Coreceptor Activity C-C Chemokine Receptor Activity C-C Chemokine Binding	Protein Binding
	Biological Process	Chemotaxis Immune Response Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus	Phototransduction Regulation Of Cell Differentiation
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events	None
GWAS		Daytime sleep phenotypes ( 27126917 ) Medication use (thyroid preparations) ( 31015401 )	Dimensional psychopathology (Cognitive) ( 29496196 ) Glucose homeostasis traits ( 25524916 ) Hand grip strength ( 27325353 ) Smoking status (ever vs never smokers) ( 30643258 )
Interacting Genes		19 interacting genes: ATP2A1 CCL1 CCL16 CCL17 CCL4 EI24 ERGIC3 GABBR1 GABRD NAGPA PAQR6 PLEKHB1 RTN3 SPNS1 SPP1 THY1 TPST1 TPST2 UCKL1	18 interacting genes: ACVR1 ATXN1 BAG3 BMPR1B BTG3 C10orf55 CCR8 DSCR9 GLIS2 GNGT1 LCOR RAP1GDS1 RBM11 RUNX1 SMAD1 TGFBR1 VENTX ZDHHC17
Entrez ID		1237	58473
HPRD ID		03497	09630
Ensembl ID		ENSG00000179934	ENSG00000021300
Uniprot IDs		P51685	Q9UF11
PDB IDs		8KFX 8KFY 8KFZ 8TLM 8U1U 8XML	Not available
GO Terms Enriched among Interactors		Chemokine Activity Eosinophil Migration Eosinophil Chemotaxis Protein-tyrosine Sulfotransferase Activity Cytokine Activity CCR Chemokine Receptor Binding Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Cell-cell Signaling Signaling Cell Communication Axolemma Cell Chemotaxis Chemokine-mediated Signaling Pathway Granulocyte Chemotaxis Negative Regulation Of Neuron Projection Regeneration 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Granulocyte Migration Positive Regulation Of Calcium Ion Transport Humoral Immune Response Positive Regulation Of Transport Golgi Apparatus Gamma-aminobutyric Acid Signaling Pathway Myeloid Leukocyte Migration Chemotaxis Leukocyte Chemotaxis Regulation Of Neuron Projection Regeneration Locomotion Positive Regulation Of Leukocyte Migration Synaptic Transmission, GABAergic Extracellular Space Maintenance Of Mitochondrion Location Regulation Of Transport Positive Regulation Of Monoatomic Ion Transport Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Peptidyl-tyrosine Sulfation N-acetylglucosamine-1-phosphodiester Alpha-N-acetylglucosaminidase Activity Calcium-dependent ATPase Activity Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Signal Transduction Relaxation Of Skeletal Muscle H Zone Regulation Of Calcium Ion Transport Positive Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Positive Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Positive Regulation Of Cardiac Muscle Cell Contraction G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential G Protein-coupled GABA Receptor Activity G Protein-coupled Receptor Dimeric Complex	Transforming Growth Factor Beta Receptor Activity, Type I Transmembrane Receptor Protein Serine/threonine Kinase Activity Activin Receptor Complex Activin Receptor Activity, Type I SMAD Binding Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway BMP Receptor Activity Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Osteoblast Differentiation Activin Binding Regulation Of Cartilage Development BMP Signaling Pathway Striated Muscle Cell Apoptotic Process Cellular Response To Growth Factor Stimulus Pharyngeal System Development Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Muscle Cell Apoptotic Process I-SMAD Binding Positive Regulation Of Cell Differentiation Transforming Growth Factor Beta Binding Poly(U) RNA Binding Positive Regulation Of RNA Metabolic Process Response To Growth Factor Osteoblast Differentiation Positive Regulation Of Extracellular Matrix Organization Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Osteoblast Differentiation Activin Receptor Signaling Pathway Cellular Response To BMP Stimulus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cartilage Development Regulation Of Extrinsic Apoptotic Signaling Pathway Pattern Specification Process Ventricular Septum Morphogenesis Regulation Of RNA Metabolic Process Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Bone Mineralization Cell Fate Commitment Positive Regulation Of Vasculature Development Regulation Of Cardiac Muscle Cell Proliferation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Growth Factor Binding Endocardial Cushion Cell Fate Commitment CAAX-box Protein Maturation Perforant Pathway To Dendrate Granule Cell Synapse Cellular Developmental Process