LAMP5 and LTB4R2

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		LAMP5	LTB4R2
Description		lysosomal associated membrane protein family member 5	leukotriene B4 receptor 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Late Endosome Plasma Membrane Synaptic Vesicle Endosome Membrane Membrane Dendrite Cytoplasmic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane Growth Cone Membrane Dendrite Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Cell Projection Synapse Recycling Endosome Recycling Endosome Membrane GABA-ergic Synapse	Nucleoplasm Plasma Membrane Membrane
	Molecular Function		Leukotriene B4 Receptor Activity G Protein-coupled Receptor Activity Leukotriene Receptor Activity G Protein-coupled Peptide Receptor Activity
	Biological Process	Establishment Of Protein Localization To Organelle Presynaptic Modulation Of Chemical Synaptic Transmission	Chemotaxis Signal Transduction G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Neuropeptide Signaling Pathway Keratinocyte Migration Leukotriene Signaling Pathway
Pathways			Leukotriene receptors G alpha (q) signalling events
Drugs			Amelubant Leukotriene B4
Diseases
GWAS			Anorectal malformation ( 31136621) Height ( 28552196)
Interacting Genes		1 interacting genes: LTB4R2	46 interacting genes: AKT1 AP2M1 CANX CEBPZ CERS1 CHPT1 CNOT10 CRELD2 CSNK2B CTSA DDOST FOLR1 GJC2 GLOD4 GPR146 GPR37 HLA-A IL17RD IMP4 LAMP5 MDH1 MGLL MYO1E OBSL1 P4HTM PER1 PIGM PKD1 RPN2 SCARB1 SEC13 SGCB SLC2A1 STMN3 SV2A SYNGR2 TMED1 TMEM94 TMUB2 TSPAN3 TSPAN4 TSPAN7 TTC9B VPS25 WFS1 YIF1B
Entrez ID		24141	56413
HPRD ID		12736	16153
Ensembl ID		ENSG00000125869	ENSG00000213906
Uniprot IDs		Q9UJQ1	B4E292 Q9NPC1
PDB IDs
Enriched GO Terms of Interacting Partners?		Pigment Granule Aggregation In Cell Center Kinociliary Basal Body Response To Inositol Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Leukotriene Signaling Pathway Leukotriene B4 Receptor Activity Leukotriene Receptor Activity Tonic Smooth Muscle Contraction Artery Smooth Muscle Contraction Negative Regulation Of Appetite Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Convergent Extension Involved In Gastrulation Leptin-mediated Signaling Pathway Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Keratinocyte Migration Negative Regulation Of Adenylate Cyclase Activity Convergent Extension Regulation Of Cilium Beat Frequency Vascular Associated Smooth Muscle Contraction Striatum Development Pigment Granule Localization Establishment Of Melanosome Localization Regulation Of Response To Food Chaperone-mediated Protein Complex Assembly Melanosome Localization Response To Leptin Brain Morphogenesis Melanosome Transport Face Development Pigment Granule Transport Regulation Of Appetite Detection Of Mechanical Stimulus Involved In Sensory Perception Vasoconstriction Regulation Of Response To Nutrient Levels Positive Regulation Of Multicellular Organism Growth Epithelial Cell Migration Regulation Of Cilium Movement G Protein-coupled Peptide Receptor Activity Photoreceptor Cell Maintenance Detection Of Mechanical Stimulus Negative Regulation Of Blood Pressure Negative Regulation Of Actin Filament Polymerization Non-motile Cilium Assembly Regulation Of Microtubule-based Movement Vasodilation Social Behavior Smooth Muscle Contraction Heart Looping Regulation Of Multicellular Organism Growth Embryonic Heart Tube Morphogenesis	Endoplasmic Reticulum Membrane Endoplasmic Reticulum Membrane Extracellular Exosome Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Vesicle Oligosaccharyltransferase Complex B
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